Plasma GDF15 level is elevated in psychosis and inversely correlated with severity

Abstract Accumulating evidence suggests that GDF15 is a biomarker for ageing and morbidity of many somatic disorders such as cancer and inflammatory disorders. Recently, elevated serum GDF15 level was proposed as a marker for mood disorder. However, psychosis severity was not investigated in relatio...

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Autores principales:	Parvin Kumar, Vincent Millischer, J. Carlos Villaescusa, Ida A. K. Nilsson, Claes-Göran Östenson, Martin Schalling, Urban Ösby, Catharina Lavebratt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/afabd871d5f8444d82d2e1fe14837afc
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spelling	oai:doaj.org-article:afabd871d5f8444d82d2e1fe14837afc2021-12-02T15:05:29ZPlasma GDF15 level is elevated in psychosis and inversely correlated with severity10.1038/s41598-017-07503-22045-2322https://doaj.org/article/afabd871d5f8444d82d2e1fe14837afc2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07503-2https://doaj.org/toc/2045-2322Abstract Accumulating evidence suggests that GDF15 is a biomarker for ageing and morbidity of many somatic disorders such as cancer and inflammatory disorders. Recently, elevated serum GDF15 level was proposed as a marker for mood disorder. However, psychosis severity was not investigated in relation to plasma GDF15 levels. In the present study we measured GDF15 levels in plasma of 120 psychosis patients compared to 120 age and gender matched healthy controls. Within the patient cohort GDF15 levels were evaluated for association with age, gender, lifestyle factors, C-reactive protein levels, psychosis severity and metabolic disorder. Psychosis patients had elevated GDF15 levels compared to controls (medianPsychosis = 744 ng/mL, mediancontrols = 516 ng/mL, p < 0.001). Within the psychosis cohort, GDF15 levels, when corrected for age, metabolic health and lifestyle factors, were negatively correlated with psychosis severity (β = −0.218, p = 0.012). While GDF15 levels were elevated in patients versus healthy controls, the negative correlation between psychosis severity and GDF15 suggests a loss of anti-inflammatory GDF15 mediated functionality in severe psychosis. Study replication in larger cohorts will be necessary to assess the potential of GDF15 as a prognostic biomarker in psychosis.Parvin KumarVincent MillischerJ. Carlos VillaescusaIda A. K. NilssonClaes-Göran ÖstensonMartin SchallingUrban ÖsbyCatharina LavebrattNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Parvin Kumar Vincent Millischer J. Carlos Villaescusa Ida A. K. Nilsson Claes-Göran Östenson Martin Schalling Urban Ösby Catharina Lavebratt Plasma GDF15 level is elevated in psychosis and inversely correlated with severity
description	Abstract Accumulating evidence suggests that GDF15 is a biomarker for ageing and morbidity of many somatic disorders such as cancer and inflammatory disorders. Recently, elevated serum GDF15 level was proposed as a marker for mood disorder. However, psychosis severity was not investigated in relation to plasma GDF15 levels. In the present study we measured GDF15 levels in plasma of 120 psychosis patients compared to 120 age and gender matched healthy controls. Within the patient cohort GDF15 levels were evaluated for association with age, gender, lifestyle factors, C-reactive protein levels, psychosis severity and metabolic disorder. Psychosis patients had elevated GDF15 levels compared to controls (medianPsychosis = 744 ng/mL, mediancontrols = 516 ng/mL, p < 0.001). Within the psychosis cohort, GDF15 levels, when corrected for age, metabolic health and lifestyle factors, were negatively correlated with psychosis severity (β = −0.218, p = 0.012). While GDF15 levels were elevated in patients versus healthy controls, the negative correlation between psychosis severity and GDF15 suggests a loss of anti-inflammatory GDF15 mediated functionality in severe psychosis. Study replication in larger cohorts will be necessary to assess the potential of GDF15 as a prognostic biomarker in psychosis.
format	article
author	Parvin Kumar Vincent Millischer J. Carlos Villaescusa Ida A. K. Nilsson Claes-Göran Östenson Martin Schalling Urban Ösby Catharina Lavebratt
author_facet	Parvin Kumar Vincent Millischer J. Carlos Villaescusa Ida A. K. Nilsson Claes-Göran Östenson Martin Schalling Urban Ösby Catharina Lavebratt
author_sort	Parvin Kumar
title	Plasma GDF15 level is elevated in psychosis and inversely correlated with severity
title_short	Plasma GDF15 level is elevated in psychosis and inversely correlated with severity
title_full	Plasma GDF15 level is elevated in psychosis and inversely correlated with severity
title_fullStr	Plasma GDF15 level is elevated in psychosis and inversely correlated with severity
title_full_unstemmed	Plasma GDF15 level is elevated in psychosis and inversely correlated with severity
title_sort	plasma gdf15 level is elevated in psychosis and inversely correlated with severity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/afabd871d5f8444d82d2e1fe14837afc
work_keys_str_mv	AT parvinkumar plasmagdf15leveliselevatedinpsychosisandinverselycorrelatedwithseverity AT vincentmillischer plasmagdf15leveliselevatedinpsychosisandinverselycorrelatedwithseverity AT jcarlosvillaescusa plasmagdf15leveliselevatedinpsychosisandinverselycorrelatedwithseverity AT idaaknilsson plasmagdf15leveliselevatedinpsychosisandinverselycorrelatedwithseverity AT claesgoranostenson plasmagdf15leveliselevatedinpsychosisandinverselycorrelatedwithseverity AT martinschalling plasmagdf15leveliselevatedinpsychosisandinverselycorrelatedwithseverity AT urbanosby plasmagdf15leveliselevatedinpsychosisandinverselycorrelatedwithseverity AT catharinalavebratt plasmagdf15leveliselevatedinpsychosisandinverselycorrelatedwithseverity
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Plasma GDF15 level is elevated in psychosis and inversely correlated with severity

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