Network-Centric Interventions to Contain the Syphilis Epidemic in San Francisco

Abstract The number of reported early syphilis cases in San Francisco has increased steadily since 2005. It is not yet clear what factors are responsible for such an increase. A recent analysis of the sexual contact network of men who have sex with men with syphilis in San Francisco has discovered a...

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Autores principales:	David Juher, Joan Saldaña, Robert Kohn, Kyle Bernstein, Caterina Scoglio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/afafe85015ba47ffa4adeefef2b096b2
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spelling	oai:doaj.org-article:afafe85015ba47ffa4adeefef2b096b22021-12-02T16:06:44ZNetwork-Centric Interventions to Contain the Syphilis Epidemic in San Francisco10.1038/s41598-017-06619-92045-2322https://doaj.org/article/afafe85015ba47ffa4adeefef2b096b22017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06619-9https://doaj.org/toc/2045-2322Abstract The number of reported early syphilis cases in San Francisco has increased steadily since 2005. It is not yet clear what factors are responsible for such an increase. A recent analysis of the sexual contact network of men who have sex with men with syphilis in San Francisco has discovered a large connected component, members of which have a significantly higher chance of syphilis and HIV compared to non-member individuals. This study investigates whether it is possible to exploit the existence of the largest connected component to design new notification strategies that can potentially contribute to reducing the number of cases. We develop a model capable of incorporating multiple types of notification strategies and compare the corresponding incidence of syphilis. Through extensive simulations, we show that notifying the community of the infection state of few central nodes appears to be the most effective approach, balancing the cost of notification and the reduction of syphilis incidence. Additionally, among the different measures of centrality, the eigenvector centrality reveals to be the best to reduce the incidence in the long term as long as the number of missing links (non-disclosed contacts) is not very large.David JuherJoan SaldañaRobert KohnKyle BernsteinCaterina ScoglioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David Juher Joan Saldaña Robert Kohn Kyle Bernstein Caterina Scoglio Network-Centric Interventions to Contain the Syphilis Epidemic in San Francisco
description	Abstract The number of reported early syphilis cases in San Francisco has increased steadily since 2005. It is not yet clear what factors are responsible for such an increase. A recent analysis of the sexual contact network of men who have sex with men with syphilis in San Francisco has discovered a large connected component, members of which have a significantly higher chance of syphilis and HIV compared to non-member individuals. This study investigates whether it is possible to exploit the existence of the largest connected component to design new notification strategies that can potentially contribute to reducing the number of cases. We develop a model capable of incorporating multiple types of notification strategies and compare the corresponding incidence of syphilis. Through extensive simulations, we show that notifying the community of the infection state of few central nodes appears to be the most effective approach, balancing the cost of notification and the reduction of syphilis incidence. Additionally, among the different measures of centrality, the eigenvector centrality reveals to be the best to reduce the incidence in the long term as long as the number of missing links (non-disclosed contacts) is not very large.
format	article
author	David Juher Joan Saldaña Robert Kohn Kyle Bernstein Caterina Scoglio
author_facet	David Juher Joan Saldaña Robert Kohn Kyle Bernstein Caterina Scoglio
author_sort	David Juher
title	Network-Centric Interventions to Contain the Syphilis Epidemic in San Francisco
title_short	Network-Centric Interventions to Contain the Syphilis Epidemic in San Francisco
title_full	Network-Centric Interventions to Contain the Syphilis Epidemic in San Francisco
title_fullStr	Network-Centric Interventions to Contain the Syphilis Epidemic in San Francisco
title_full_unstemmed	Network-Centric Interventions to Contain the Syphilis Epidemic in San Francisco
title_sort	network-centric interventions to contain the syphilis epidemic in san francisco
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/afafe85015ba47ffa4adeefef2b096b2
work_keys_str_mv	AT davidjuher networkcentricinterventionstocontainthesyphilisepidemicinsanfrancisco AT joansaldana networkcentricinterventionstocontainthesyphilisepidemicinsanfrancisco AT robertkohn networkcentricinterventionstocontainthesyphilisepidemicinsanfrancisco AT kylebernstein networkcentricinterventionstocontainthesyphilisepidemicinsanfrancisco AT caterinascoglio networkcentricinterventionstocontainthesyphilisepidemicinsanfrancisco
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Network-Centric Interventions to Contain the Syphilis Epidemic in San Francisco

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