Satellite cells derived from obese humans with type 2 diabetes and differentiated into myocytes in vitro exhibit abnormal response to IL-6.

Satellite cells derived from obese humans with type 2 diabetes and differentiated into myocytes in vitro exhibit abnormal response to IL-6.

Obesity and type 2 diabetes are associated with chronically elevated systemic levels of IL-6, a pro-inflammatory cytokine with a role in skeletal muscle metabolism that signals through the IL-6 receptor (IL-6Rα). We hypothesized that skeletal muscle in obesity-associated type 2 diabetes develops a r...

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Bibliographic Details
Main Authors: Camilla Scheele, Søren Nielsen, Meghan Kelly, Christa Broholm, Anders Rinnov Nielsen, Sarah Taudorf, Maria Pedersen, Christian P Fischer, Bente Klarlund Pedersen
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/afb038f9a64f4c7cb29883e53fc7d203
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