Bronchoscopy-Guided Intervention Therapy With Extracorporeal Membrane Oxygenation Support for Relapsing Polychondritis With Severe Tracheobronchomalacia: A Case Report and Literature Review

Relapsing polychondritis is an immune disorder of unknown etiology involving multiple systems that is characterized by persistent inflammation and destruction of cartilage, including the ears, nose, costal, joint, and airways. Airway involvement caused by relapsing polychondritis is common, and trac...

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Autores principales: Pengcheng Zhou, Bing Fu, Chuantao Zhang, Keling Chen, Qianming Xia, Wenjun Tang, Wei Yu, Wenhui Huang
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Publicado: Frontiers Media S.A. 2021
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spelling oai:doaj.org-article:afb2d0a12ede45238ff3d61722d5c7c32021-11-30T11:56:48ZBronchoscopy-Guided Intervention Therapy With Extracorporeal Membrane Oxygenation Support for Relapsing Polychondritis With Severe Tracheobronchomalacia: A Case Report and Literature Review2296-858X10.3389/fmed.2021.695505https://doaj.org/article/afb2d0a12ede45238ff3d61722d5c7c32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.695505/fullhttps://doaj.org/toc/2296-858XRelapsing polychondritis is an immune disorder of unknown etiology involving multiple systems that is characterized by persistent inflammation and destruction of cartilage, including the ears, nose, costal, joint, and airways. Airway involvement caused by relapsing polychondritis is common, and tracheobronchomalacia is the most serious complication, which is life-threatening. Currently, the exact mechanism of relapsing polychondritis with tracheobronchomalacia is unknown. Although glucocorticoids and immunosuppressive agents are administered, failures often occur. Currently, bronchoscopy-guided intervention therapy used in tracheobronchomalacia caused by chronic obstructive pulmonary disease or other etiology has gradually increased, but bronchoscopy-guided intervention therapy with extracorporeal membrane oxygenation assist used in tracheobronchomalacia caused by relapsing polychondritis has not been reported. Here, we report a case of relapsing polychondritis with severe tracheobronchomalacia. Although drug therapy was provided and airway stent implantation was performed, the tracheal stenosis was further aggravated. Because conventional anesthesia and mechanical ventilation cannot meet the needs of bronchoscopy-guided intervention therapy or guarantee sufficient safety. The intervention treatment was performed with the support of extracorporeal membrane oxygenation, which was successfully completed without obvious complications. The symptoms were significantly improved, and the patient was discharged uneventfully.Pengcheng ZhouBing FuChuantao ZhangKeling ChenQianming XiaWenjun TangWei YuWenhui HuangFrontiers Media S.A.articleextracorporeal membrane oxygenationrelapsing polychondritistracheobronchomalaciasevere airway stenosisbronchoscopyinterventional therapyMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution DOAJ
collection DOAJ
language EN
topic extracorporeal membrane oxygenation
relapsing polychondritis
tracheobronchomalacia
severe airway stenosis
bronchoscopy
interventional therapy
Medicine (General)
R5-920
spellingShingle extracorporeal membrane oxygenation
relapsing polychondritis
tracheobronchomalacia
severe airway stenosis
bronchoscopy
interventional therapy
Medicine (General)
R5-920
Pengcheng Zhou
Bing Fu
Chuantao Zhang
Keling Chen
Qianming Xia
Wenjun Tang
Wei Yu
Wenhui Huang
Bronchoscopy-Guided Intervention Therapy With Extracorporeal Membrane Oxygenation Support for Relapsing Polychondritis With Severe Tracheobronchomalacia: A Case Report and Literature Review
description Relapsing polychondritis is an immune disorder of unknown etiology involving multiple systems that is characterized by persistent inflammation and destruction of cartilage, including the ears, nose, costal, joint, and airways. Airway involvement caused by relapsing polychondritis is common, and tracheobronchomalacia is the most serious complication, which is life-threatening. Currently, the exact mechanism of relapsing polychondritis with tracheobronchomalacia is unknown. Although glucocorticoids and immunosuppressive agents are administered, failures often occur. Currently, bronchoscopy-guided intervention therapy used in tracheobronchomalacia caused by chronic obstructive pulmonary disease or other etiology has gradually increased, but bronchoscopy-guided intervention therapy with extracorporeal membrane oxygenation assist used in tracheobronchomalacia caused by relapsing polychondritis has not been reported. Here, we report a case of relapsing polychondritis with severe tracheobronchomalacia. Although drug therapy was provided and airway stent implantation was performed, the tracheal stenosis was further aggravated. Because conventional anesthesia and mechanical ventilation cannot meet the needs of bronchoscopy-guided intervention therapy or guarantee sufficient safety. The intervention treatment was performed with the support of extracorporeal membrane oxygenation, which was successfully completed without obvious complications. The symptoms were significantly improved, and the patient was discharged uneventfully.
format article
author Pengcheng Zhou
Bing Fu
Chuantao Zhang
Keling Chen
Qianming Xia
Wenjun Tang
Wei Yu
Wenhui Huang
author_facet Pengcheng Zhou
Bing Fu
Chuantao Zhang
Keling Chen
Qianming Xia
Wenjun Tang
Wei Yu
Wenhui Huang
author_sort Pengcheng Zhou
title Bronchoscopy-Guided Intervention Therapy With Extracorporeal Membrane Oxygenation Support for Relapsing Polychondritis With Severe Tracheobronchomalacia: A Case Report and Literature Review
title_short Bronchoscopy-Guided Intervention Therapy With Extracorporeal Membrane Oxygenation Support for Relapsing Polychondritis With Severe Tracheobronchomalacia: A Case Report and Literature Review
title_full Bronchoscopy-Guided Intervention Therapy With Extracorporeal Membrane Oxygenation Support for Relapsing Polychondritis With Severe Tracheobronchomalacia: A Case Report and Literature Review
title_fullStr Bronchoscopy-Guided Intervention Therapy With Extracorporeal Membrane Oxygenation Support for Relapsing Polychondritis With Severe Tracheobronchomalacia: A Case Report and Literature Review
title_full_unstemmed Bronchoscopy-Guided Intervention Therapy With Extracorporeal Membrane Oxygenation Support for Relapsing Polychondritis With Severe Tracheobronchomalacia: A Case Report and Literature Review
title_sort bronchoscopy-guided intervention therapy with extracorporeal membrane oxygenation support for relapsing polychondritis with severe tracheobronchomalacia: a case report and literature review
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/afb2d0a12ede45238ff3d61722d5c7c3
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