Efficacy of compressed sodium chloride (CSC) against E. coli and Candida auris in minutes and methods improvement for testing

Abstract Controlling infections has become one of the biggest problems in the world, whether measured in lives lost or money spent. This is worsening as pathogens continue becoming resistant to therapeutics. Antimicrobial surfaces are one strategy being investigated in an attempt to decrease the spr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lan N. Truong, Brayden D. Whitlock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/afb6a2dca538420188e15c51103870d8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:afb6a2dca538420188e15c51103870d8
record_format	dspace
spelling	oai:doaj.org-article:afb6a2dca538420188e15c51103870d82021-12-02T11:46:07ZEfficacy of compressed sodium chloride (CSC) against E. coli and Candida auris in minutes and methods improvement for testing10.1038/s41598-020-79212-22045-2322https://doaj.org/article/afb6a2dca538420188e15c51103870d82021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79212-2https://doaj.org/toc/2045-2322Abstract Controlling infections has become one of the biggest problems in the world, whether measured in lives lost or money spent. This is worsening as pathogens continue becoming resistant to therapeutics. Antimicrobial surfaces are one strategy being investigated in an attempt to decrease the spread of infections through the most common route of transmission: surfaces, including hands. Regulators have chosen two hours as the time point at which efficacy should be measured. The objectives of this study were to characterize the new antimicrobial surface compressed sodium chloride (CSC) so that its action may be understood at timepoints more relevant to real-time infection control, under two minutes; to develop a sensitive method to test efficacy at short time points; and to investigate antifungal properties for the first time. E. coli and Candida auris are added to surfaces, and the surfaces are monitored by contact plate, or by washing into collection vats. An improved method of testing antimicrobial efficacy is reported. Antimicrobial CSC achieves at least 99.9% reduction of E. coli in the first two minutes of contact, and at least 99% reduction of C. auris in one minute.Lan N. TruongBrayden D. WhitlockNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lan N. Truong Brayden D. Whitlock Efficacy of compressed sodium chloride (CSC) against E. coli and Candida auris in minutes and methods improvement for testing
description	Abstract Controlling infections has become one of the biggest problems in the world, whether measured in lives lost or money spent. This is worsening as pathogens continue becoming resistant to therapeutics. Antimicrobial surfaces are one strategy being investigated in an attempt to decrease the spread of infections through the most common route of transmission: surfaces, including hands. Regulators have chosen two hours as the time point at which efficacy should be measured. The objectives of this study were to characterize the new antimicrobial surface compressed sodium chloride (CSC) so that its action may be understood at timepoints more relevant to real-time infection control, under two minutes; to develop a sensitive method to test efficacy at short time points; and to investigate antifungal properties for the first time. E. coli and Candida auris are added to surfaces, and the surfaces are monitored by contact plate, or by washing into collection vats. An improved method of testing antimicrobial efficacy is reported. Antimicrobial CSC achieves at least 99.9% reduction of E. coli in the first two minutes of contact, and at least 99% reduction of C. auris in one minute.
format	article
author	Lan N. Truong Brayden D. Whitlock
author_facet	Lan N. Truong Brayden D. Whitlock
author_sort	Lan N. Truong
title	Efficacy of compressed sodium chloride (CSC) against E. coli and Candida auris in minutes and methods improvement for testing
title_short	Efficacy of compressed sodium chloride (CSC) against E. coli and Candida auris in minutes and methods improvement for testing
title_full	Efficacy of compressed sodium chloride (CSC) against E. coli and Candida auris in minutes and methods improvement for testing
title_fullStr	Efficacy of compressed sodium chloride (CSC) against E. coli and Candida auris in minutes and methods improvement for testing
title_full_unstemmed	Efficacy of compressed sodium chloride (CSC) against E. coli and Candida auris in minutes and methods improvement for testing
title_sort	efficacy of compressed sodium chloride (csc) against e. coli and candida auris in minutes and methods improvement for testing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/afb6a2dca538420188e15c51103870d8
work_keys_str_mv	AT lanntruong efficacyofcompressedsodiumchloridecscagainstecoliandcandidaaurisinminutesandmethodsimprovementfortesting AT braydendwhitlock efficacyofcompressedsodiumchloridecscagainstecoliandcandidaaurisinminutesandmethodsimprovementfortesting
_version_	1718395247004745728

Efficacy of compressed sodium chloride (CSC) against E. coli and Candida auris in minutes and methods improvement for testing

Ejemplares similares