Glioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies

Gliomas exhibit high intra-tumoral histological and molecular heterogeneity. Introducing stereotactic biopsy, we achieved a superior molecular analysis of glioma using O-(2-18F-fluoroethyl)-L-tyrosine (FET)-positron emission tomography (PET) and diffusion-weighted magnetic resonance imaging (DWI). P...

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Autores principales:	Ye Cheng, Shuangshuang Song, Yukui Wei, Geng Xu, Yang An, Jie Ma, Hongwei Yang, Zhigang Qi, Xinru Xiao, Jie Bai, Lixin Xu, Zeliang Hu, Tingting Sun, Leiming Wang, Jie Lu, Qingtang Lin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hybrid PET/MR 18F-FET DWI glioma phenotyping biopsy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/afb6ad53118f460eb0b9a11a83082980
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spelling	oai:doaj.org-article:afb6ad53118f460eb0b9a11a830829802021-12-01T13:16:04ZGlioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies2234-943X10.3389/fonc.2021.743655https://doaj.org/article/afb6ad53118f460eb0b9a11a830829802021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.743655/fullhttps://doaj.org/toc/2234-943XGliomas exhibit high intra-tumoral histological and molecular heterogeneity. Introducing stereotactic biopsy, we achieved a superior molecular analysis of glioma using O-(2-18F-fluoroethyl)-L-tyrosine (FET)-positron emission tomography (PET) and diffusion-weighted magnetic resonance imaging (DWI). Patients underwent simultaneous DWI and FET-PET scans. Correlations between biopsy-derived tumor tissue values, such as the tumor-to-background ratio (TBR) and apparent diffusion coefficient (ADC)/exponential ADC (eADC) and histopathological diagnoses and those between relevant genes and TBR and ADC values were determined. Tumor regions with human telomerase reverse transcriptase (hTERT) mutation had higher TBR and lower ADC values. Tumor protein P53 mutation correlated with lower TBR and higher ADC values. α-thalassemia/mental-retardation-syndrome-X-linked gene (ATRX) correlated with higher ADC values. 1p/19q codeletion and epidermal growth factor receptor (EGFR) mutations correlated with lower ADC values. Isocitrate dehydrogenase 1 (IDH1) mutations correlated with higher TBRmean values. No correlation existed between TBRmax/TBRmean/ADC/eADC values and phosphatase and tensin homolog mutations (PTEN) or O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation. Furthermore, TBR/ADC combination had a higher diagnostic accuracy than each single imaging method for high-grade and IDH1-, hTERT-, and EGFR-mutated gliomas. This is the first study establishing the accurate diagnostic criteria for glioma based on FET-PET and DWI.Ye ChengYe ChengYe ChengShuangshuang SongShuangshuang SongShuangshuang SongYukui WeiYukui WeiGeng XuGeng XuYang AnYang AnJie MaHongwei YangZhigang QiXinru XiaoXinru XiaoJie BaiJie BaiLixin XuLixin XuZeliang HuTingting SunLeiming WangJie LuJie LuQingtang LinQingtang LinFrontiers Media S.A.articlehybrid PET/MR18F-FETDWIglioma phenotypingbiopsyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hybrid PET/MR 18F-FET DWI glioma phenotyping biopsy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hybrid PET/MR 18F-FET DWI glioma phenotyping biopsy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ye Cheng Ye Cheng Ye Cheng Shuangshuang Song Shuangshuang Song Shuangshuang Song Yukui Wei Yukui Wei Geng Xu Geng Xu Yang An Yang An Jie Ma Hongwei Yang Zhigang Qi Xinru Xiao Xinru Xiao Jie Bai Jie Bai Lixin Xu Lixin Xu Zeliang Hu Tingting Sun Leiming Wang Jie Lu Jie Lu Qingtang Lin Qingtang Lin Glioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies
description	Gliomas exhibit high intra-tumoral histological and molecular heterogeneity. Introducing stereotactic biopsy, we achieved a superior molecular analysis of glioma using O-(2-18F-fluoroethyl)-L-tyrosine (FET)-positron emission tomography (PET) and diffusion-weighted magnetic resonance imaging (DWI). Patients underwent simultaneous DWI and FET-PET scans. Correlations between biopsy-derived tumor tissue values, such as the tumor-to-background ratio (TBR) and apparent diffusion coefficient (ADC)/exponential ADC (eADC) and histopathological diagnoses and those between relevant genes and TBR and ADC values were determined. Tumor regions with human telomerase reverse transcriptase (hTERT) mutation had higher TBR and lower ADC values. Tumor protein P53 mutation correlated with lower TBR and higher ADC values. α-thalassemia/mental-retardation-syndrome-X-linked gene (ATRX) correlated with higher ADC values. 1p/19q codeletion and epidermal growth factor receptor (EGFR) mutations correlated with lower ADC values. Isocitrate dehydrogenase 1 (IDH1) mutations correlated with higher TBRmean values. No correlation existed between TBRmax/TBRmean/ADC/eADC values and phosphatase and tensin homolog mutations (PTEN) or O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation. Furthermore, TBR/ADC combination had a higher diagnostic accuracy than each single imaging method for high-grade and IDH1-, hTERT-, and EGFR-mutated gliomas. This is the first study establishing the accurate diagnostic criteria for glioma based on FET-PET and DWI.
format	article
author	Ye Cheng Ye Cheng Ye Cheng Shuangshuang Song Shuangshuang Song Shuangshuang Song Yukui Wei Yukui Wei Geng Xu Geng Xu Yang An Yang An Jie Ma Hongwei Yang Zhigang Qi Xinru Xiao Xinru Xiao Jie Bai Jie Bai Lixin Xu Lixin Xu Zeliang Hu Tingting Sun Leiming Wang Jie Lu Jie Lu Qingtang Lin Qingtang Lin
author_facet	Ye Cheng Ye Cheng Ye Cheng Shuangshuang Song Shuangshuang Song Shuangshuang Song Yukui Wei Yukui Wei Geng Xu Geng Xu Yang An Yang An Jie Ma Hongwei Yang Zhigang Qi Xinru Xiao Xinru Xiao Jie Bai Jie Bai Lixin Xu Lixin Xu Zeliang Hu Tingting Sun Leiming Wang Jie Lu Jie Lu Qingtang Lin Qingtang Lin
author_sort	Ye Cheng
title	Glioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies
title_short	Glioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies
title_full	Glioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies
title_fullStr	Glioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies
title_full_unstemmed	Glioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies
title_sort	glioma imaging by o-(2-18f-fluoroethyl)-l-tyrosine pet and diffusion-weighted mri and correlation with molecular phenotypes, validated by pet/mr-guided biopsies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/afb6ad53118f460eb0b9a11a83082980
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Glioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies

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