Placental and maternal sFlt1/PlGF expression in gestational diabetes mellitus

Abstract Gestational diabetes mellitus (GDM) and preeclampsia (PE) are both characterized by endothelial dysfunction and GDM women have higher incidence of PE. The placenta plays a key role in PE pathogenesis but its contribution to PE during GDM remains unclear. Herein, we compared placental and ma...

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Autores principales:	Anna Maria Nuzzo, Domenica Giuffrida, Laura Moretti, Paola Re, Giorgio Grassi, Guido Menato, Alessandro Rolfo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/afba78b2b8c3438ca382df36cb00a6f8
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spelling	oai:doaj.org-article:afba78b2b8c3438ca382df36cb00a6f82021-12-02T13:24:36ZPlacental and maternal sFlt1/PlGF expression in gestational diabetes mellitus10.1038/s41598-021-81785-52045-2322https://doaj.org/article/afba78b2b8c3438ca382df36cb00a6f82021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81785-5https://doaj.org/toc/2045-2322Abstract Gestational diabetes mellitus (GDM) and preeclampsia (PE) are both characterized by endothelial dysfunction and GDM women have higher incidence of PE. The placenta plays a key role in PE pathogenesis but its contribution to PE during GDM remains unclear. Herein, we compared placental and maternal blood anti-angiogenic soluble fms-like tyrosine kinase-1 (sFlt1) and pro-angiogenic Placental Growth Factor (PlGF) expressions in GDM and GDM-PE pregnancies compared to controls (CTRL) and PE cases. Electrochemiluminescence immunoassays showed a significantly higher maternal blood sFlt1/PlGF values in GDM-PE relative to CTRL and GDM pregnancies. We reported that placental PlGF gene expression was significantly decreased in GDM, PE and GDM-PE relative to CTRL. However, PlGF protein levels were significantly increased in GDM and GDM-PE relative to CTRL and PE placentae. Finally, sFlt1 gene expression was significantly increased in PE relative to CTRL, GDM and GDM-PE placentae. In contrast, sFlt1 protein expression was significantly decreased in GDM-PE relative to CTRL, GDM and PE placentae. Finally, higher sFlt1/PlGF ratio in GDM-PE maternal blood suggest that sFlt1 overproduction is related to PE onset also in GDM pregnancies even though characterized by a less severe endothelial dysfunction in terms of angiogenic biomarkers.Anna Maria NuzzoDomenica GiuffridaLaura MorettiPaola ReGiorgio GrassiGuido MenatoAlessandro RolfoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Maria Nuzzo Domenica Giuffrida Laura Moretti Paola Re Giorgio Grassi Guido Menato Alessandro Rolfo Placental and maternal sFlt1/PlGF expression in gestational diabetes mellitus
description	Abstract Gestational diabetes mellitus (GDM) and preeclampsia (PE) are both characterized by endothelial dysfunction and GDM women have higher incidence of PE. The placenta plays a key role in PE pathogenesis but its contribution to PE during GDM remains unclear. Herein, we compared placental and maternal blood anti-angiogenic soluble fms-like tyrosine kinase-1 (sFlt1) and pro-angiogenic Placental Growth Factor (PlGF) expressions in GDM and GDM-PE pregnancies compared to controls (CTRL) and PE cases. Electrochemiluminescence immunoassays showed a significantly higher maternal blood sFlt1/PlGF values in GDM-PE relative to CTRL and GDM pregnancies. We reported that placental PlGF gene expression was significantly decreased in GDM, PE and GDM-PE relative to CTRL. However, PlGF protein levels were significantly increased in GDM and GDM-PE relative to CTRL and PE placentae. Finally, sFlt1 gene expression was significantly increased in PE relative to CTRL, GDM and GDM-PE placentae. In contrast, sFlt1 protein expression was significantly decreased in GDM-PE relative to CTRL, GDM and PE placentae. Finally, higher sFlt1/PlGF ratio in GDM-PE maternal blood suggest that sFlt1 overproduction is related to PE onset also in GDM pregnancies even though characterized by a less severe endothelial dysfunction in terms of angiogenic biomarkers.
format	article
author	Anna Maria Nuzzo Domenica Giuffrida Laura Moretti Paola Re Giorgio Grassi Guido Menato Alessandro Rolfo
author_facet	Anna Maria Nuzzo Domenica Giuffrida Laura Moretti Paola Re Giorgio Grassi Guido Menato Alessandro Rolfo
author_sort	Anna Maria Nuzzo
title	Placental and maternal sFlt1/PlGF expression in gestational diabetes mellitus
title_short	Placental and maternal sFlt1/PlGF expression in gestational diabetes mellitus
title_full	Placental and maternal sFlt1/PlGF expression in gestational diabetes mellitus
title_fullStr	Placental and maternal sFlt1/PlGF expression in gestational diabetes mellitus
title_full_unstemmed	Placental and maternal sFlt1/PlGF expression in gestational diabetes mellitus
title_sort	placental and maternal sflt1/plgf expression in gestational diabetes mellitus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/afba78b2b8c3438ca382df36cb00a6f8
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Placental and maternal sFlt1/PlGF expression in gestational diabetes mellitus

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