Biodegradable Cable-Tie Rapamycin-eluting Stents

Abstract “Cable-tie” type biodegradable stents with drug-eluting nanofiber were developed to treat rabbit denuded arteries in this study. Biodegradable stents were fabricated using poly-L-lactide film following being cut and rolled into a cable-tie type stent. Additionally, drug-eluting biodegradabl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cheng-Hung Lee, Ming-Jer Hsieh, Shang-Hung Chang, Chang-Lin Chiang, Ching-Lung Fan, Shih-Jung Liu, Wei-Jan Chen, Chao-Jan Wang, Ming-Yi Hsu, Kuo-Chun Hung, Chung-Chuan Chou, Po-Cheng Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/afbc9651fa1746f8bb328452ca39accf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:afbc9651fa1746f8bb328452ca39accf
record_format	dspace
spelling	oai:doaj.org-article:afbc9651fa1746f8bb328452ca39accf2021-12-02T11:40:13ZBiodegradable Cable-Tie Rapamycin-eluting Stents10.1038/s41598-017-00131-w2045-2322https://doaj.org/article/afbc9651fa1746f8bb328452ca39accf2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00131-whttps://doaj.org/toc/2045-2322Abstract “Cable-tie” type biodegradable stents with drug-eluting nanofiber were developed to treat rabbit denuded arteries in this study. Biodegradable stents were fabricated using poly-L-lactide film following being cut and rolled into a cable-tie type stent. Additionally, drug-eluting biodegradable nanofiber tubes were electrospun from a solution containing poly (lactic-co-glycolic acid), rapamycin, and hexafluoroisopropanol, and then mounted onto the stents. The fabricated rapamycin-eluting cable-tie stents exhibited excellent mechanical properties on evaluation of compression test and collapse pressure, and less than 8% weight loss following being immersed in phosphate-buffered saline for 16 weeks. Furthermore, the biodegradable stents delivered high rapamycin concentrations for over 4 weeks and achieved substantial reductions in intimal hyperplasia associated with elevated heme oxygenase-1 and calponin level on the denuded rabbit arteries during 6 months of follow-up. The drug-eluting cable-tie type stents developed in this study might have high potential impacts for the local drug delivery to treat various vascular diseases.Cheng-Hung LeeMing-Jer HsiehShang-Hung ChangChang-Lin ChiangChing-Lung FanShih-Jung LiuWei-Jan ChenChao-Jan WangMing-Yi HsuKuo-Chun HungChung-Chuan ChouPo-Cheng ChangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cheng-Hung Lee Ming-Jer Hsieh Shang-Hung Chang Chang-Lin Chiang Ching-Lung Fan Shih-Jung Liu Wei-Jan Chen Chao-Jan Wang Ming-Yi Hsu Kuo-Chun Hung Chung-Chuan Chou Po-Cheng Chang Biodegradable Cable-Tie Rapamycin-eluting Stents
description	Abstract “Cable-tie” type biodegradable stents with drug-eluting nanofiber were developed to treat rabbit denuded arteries in this study. Biodegradable stents were fabricated using poly-L-lactide film following being cut and rolled into a cable-tie type stent. Additionally, drug-eluting biodegradable nanofiber tubes were electrospun from a solution containing poly (lactic-co-glycolic acid), rapamycin, and hexafluoroisopropanol, and then mounted onto the stents. The fabricated rapamycin-eluting cable-tie stents exhibited excellent mechanical properties on evaluation of compression test and collapse pressure, and less than 8% weight loss following being immersed in phosphate-buffered saline for 16 weeks. Furthermore, the biodegradable stents delivered high rapamycin concentrations for over 4 weeks and achieved substantial reductions in intimal hyperplasia associated with elevated heme oxygenase-1 and calponin level on the denuded rabbit arteries during 6 months of follow-up. The drug-eluting cable-tie type stents developed in this study might have high potential impacts for the local drug delivery to treat various vascular diseases.
format	article
author	Cheng-Hung Lee Ming-Jer Hsieh Shang-Hung Chang Chang-Lin Chiang Ching-Lung Fan Shih-Jung Liu Wei-Jan Chen Chao-Jan Wang Ming-Yi Hsu Kuo-Chun Hung Chung-Chuan Chou Po-Cheng Chang
author_facet	Cheng-Hung Lee Ming-Jer Hsieh Shang-Hung Chang Chang-Lin Chiang Ching-Lung Fan Shih-Jung Liu Wei-Jan Chen Chao-Jan Wang Ming-Yi Hsu Kuo-Chun Hung Chung-Chuan Chou Po-Cheng Chang
author_sort	Cheng-Hung Lee
title	Biodegradable Cable-Tie Rapamycin-eluting Stents
title_short	Biodegradable Cable-Tie Rapamycin-eluting Stents
title_full	Biodegradable Cable-Tie Rapamycin-eluting Stents
title_fullStr	Biodegradable Cable-Tie Rapamycin-eluting Stents
title_full_unstemmed	Biodegradable Cable-Tie Rapamycin-eluting Stents
title_sort	biodegradable cable-tie rapamycin-eluting stents
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/afbc9651fa1746f8bb328452ca39accf
work_keys_str_mv	AT chenghunglee biodegradablecabletierapamycinelutingstents AT mingjerhsieh biodegradablecabletierapamycinelutingstents AT shanghungchang biodegradablecabletierapamycinelutingstents AT changlinchiang biodegradablecabletierapamycinelutingstents AT chinglungfan biodegradablecabletierapamycinelutingstents AT shihjungliu biodegradablecabletierapamycinelutingstents AT weijanchen biodegradablecabletierapamycinelutingstents AT chaojanwang biodegradablecabletierapamycinelutingstents AT mingyihsu biodegradablecabletierapamycinelutingstents AT kuochunhung biodegradablecabletierapamycinelutingstents AT chungchuanchou biodegradablecabletierapamycinelutingstents AT pochengchang biodegradablecabletierapamycinelutingstents
_version_	1718395720058273792

Biodegradable Cable-Tie Rapamycin-eluting Stents

Ejemplares similares