Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model

Self-grooming is an innate, cephalo-caudal progression of body cleaning behaviors that are found in normal rodents but exhibit repetitive and stereotyped patterns in several mouse models, such as autism spectrum disorders (ASDs). It is also recognized as a marker of stress and anxiety. Mice with Sha...

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Autores principales:	Haiying Liu, Xin Huang, Jinwei Xu, Honghui Mao, Yaohao Li, Keke Ren, Guaiguai Ma, Qian Xue, Huiren Tao, Shengxi Wu, Wenting Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Stereotyped self-grooming Anxiety Shank3 Restraint Inflammatory pain Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/afbcc5e69918403ea7dcae54442cf8c3
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spelling	oai:doaj.org-article:afbcc5e69918403ea7dcae54442cf8c32021-11-16T04:10:45ZDissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model2352-289510.1016/j.ynstr.2021.100417https://doaj.org/article/afbcc5e69918403ea7dcae54442cf8c32021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352289521001259https://doaj.org/toc/2352-2895Self-grooming is an innate, cephalo-caudal progression of body cleaning behaviors that are found in normal rodents but exhibit repetitive and stereotyped patterns in several mouse models, such as autism spectrum disorders (ASDs). It is also recognized as a marker of stress and anxiety. Mice with Shank3B gene knockout (KO) exhibit typical ASD-like behavioral abnormalities, including stereotyped self-grooming and increased levels of anxiety. However, the exact relationship between anxiety and stereotyped self-grooming in certain types of animal models is not clear. We selected three animal models with high anxiety to compare their self-grooming parameters. First, we confirmed that Shank3B KO mice (ASD model), acute restraint stress mouse model (stress model), and chronic inflammatory pain mouse model (pain model) all showed increased anxiety levels in the open field test (OFT) and elevated plus maze (EPM). We found that only the ASD model and the stress model produced increased total grooming duration. The pain model only exhibited an increasing trend of mean self-grooming duration. We used the grooming analysis algorithm to examine the self-grooming microstructure and assess the cephalo-caudal progression of grooming behavior. The results showed distinct self-grooming microstructures in these three models. The anxiolytic drug diazepam relieved the anxiety level and the total time of grooming in the ASD and stress models. The grooming microstructure was not restored in Shank3B KO mice but was partially relieved in the stress model, which suggested that anxiety aggravated stereotyped self-grooming duration but not the grooming microstructure in the ASD mouse model. Our results indicated that stereotyped behavior and anxiety may be shared by separate, but interacting, neural circuits in distinct disease models, which may be useful to understand the mechanisms and develop potential treatments for stereotyped behaviors and anxiety.Haiying LiuXin HuangJinwei XuHonghui MaoYaohao LiKeke RenGuaiguai MaQian XueHuiren TaoShengxi WuWenting WangElsevierarticleStereotyped self-groomingAnxietyShank3RestraintInflammatory painNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429Neurophysiology and neuropsychologyQP351-495ENNeurobiology of Stress, Vol 15, Iss , Pp 100417- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Stereotyped self-grooming Anxiety Shank3 Restraint Inflammatory pain Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Neurophysiology and neuropsychology QP351-495
spellingShingle	Stereotyped self-grooming Anxiety Shank3 Restraint Inflammatory pain Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Neurophysiology and neuropsychology QP351-495 Haiying Liu Xin Huang Jinwei Xu Honghui Mao Yaohao Li Keke Ren Guaiguai Ma Qian Xue Huiren Tao Shengxi Wu Wenting Wang Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model
description	Self-grooming is an innate, cephalo-caudal progression of body cleaning behaviors that are found in normal rodents but exhibit repetitive and stereotyped patterns in several mouse models, such as autism spectrum disorders (ASDs). It is also recognized as a marker of stress and anxiety. Mice with Shank3B gene knockout (KO) exhibit typical ASD-like behavioral abnormalities, including stereotyped self-grooming and increased levels of anxiety. However, the exact relationship between anxiety and stereotyped self-grooming in certain types of animal models is not clear. We selected three animal models with high anxiety to compare their self-grooming parameters. First, we confirmed that Shank3B KO mice (ASD model), acute restraint stress mouse model (stress model), and chronic inflammatory pain mouse model (pain model) all showed increased anxiety levels in the open field test (OFT) and elevated plus maze (EPM). We found that only the ASD model and the stress model produced increased total grooming duration. The pain model only exhibited an increasing trend of mean self-grooming duration. We used the grooming analysis algorithm to examine the self-grooming microstructure and assess the cephalo-caudal progression of grooming behavior. The results showed distinct self-grooming microstructures in these three models. The anxiolytic drug diazepam relieved the anxiety level and the total time of grooming in the ASD and stress models. The grooming microstructure was not restored in Shank3B KO mice but was partially relieved in the stress model, which suggested that anxiety aggravated stereotyped self-grooming duration but not the grooming microstructure in the ASD mouse model. Our results indicated that stereotyped behavior and anxiety may be shared by separate, but interacting, neural circuits in distinct disease models, which may be useful to understand the mechanisms and develop potential treatments for stereotyped behaviors and anxiety.
format	article
author	Haiying Liu Xin Huang Jinwei Xu Honghui Mao Yaohao Li Keke Ren Guaiguai Ma Qian Xue Huiren Tao Shengxi Wu Wenting Wang
author_facet	Haiying Liu Xin Huang Jinwei Xu Honghui Mao Yaohao Li Keke Ren Guaiguai Ma Qian Xue Huiren Tao Shengxi Wu Wenting Wang
author_sort	Haiying Liu
title	Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model
title_short	Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model
title_full	Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model
title_fullStr	Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model
title_full_unstemmed	Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model
title_sort	dissection of the relationship between anxiety and stereotyped self-grooming using the shank3b mutant autistic model, acute stress model and chronic pain model
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/afbcc5e69918403ea7dcae54442cf8c3
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Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model

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