Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression

Genome wide association studies have identified multiple risk loci for multiple myeloma. Here, the authors show that the expression of CDCA7Lis associated with patient survival and expression of the gene is influenced by a risk variant at 7p15.3, which creates a transcription factor binding site for...

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Autores principales:	Ni Li, David C. Johnson, Niels Weinhold, James B. Studd, Giulia Orlando, Fabio Mirabella, Jonathan S. Mitchell, Tobias Meissner, Martin Kaiser, Hartmut Goldschmidt, Kari Hemminki, Gareth J. Morgan, Richard S. Houlston
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/afbf3a5c64704e4682e918800c30d427
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spelling	oai:doaj.org-article:afbf3a5c64704e4682e918800c30d4272021-12-02T16:49:41ZMultiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression10.1038/ncomms136562041-1723https://doaj.org/article/afbf3a5c64704e4682e918800c30d4272016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13656https://doaj.org/toc/2041-1723Genome wide association studies have identified multiple risk loci for multiple myeloma. Here, the authors show that the expression of CDCA7Lis associated with patient survival and expression of the gene is influenced by a risk variant at 7p15.3, which creates a transcription factor binding site for IRF4.Ni LiDavid C. JohnsonNiels WeinholdJames B. StuddGiulia OrlandoFabio MirabellaJonathan S. MitchellTobias MeissnerMartin KaiserHartmut GoldschmidtKari HemminkiGareth J. MorganRichard S. HoulstonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ni Li David C. Johnson Niels Weinhold James B. Studd Giulia Orlando Fabio Mirabella Jonathan S. Mitchell Tobias Meissner Martin Kaiser Hartmut Goldschmidt Kari Hemminki Gareth J. Morgan Richard S. Houlston Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression
description	Genome wide association studies have identified multiple risk loci for multiple myeloma. Here, the authors show that the expression of CDCA7Lis associated with patient survival and expression of the gene is influenced by a risk variant at 7p15.3, which creates a transcription factor binding site for IRF4.
format	article
author	Ni Li David C. Johnson Niels Weinhold James B. Studd Giulia Orlando Fabio Mirabella Jonathan S. Mitchell Tobias Meissner Martin Kaiser Hartmut Goldschmidt Kari Hemminki Gareth J. Morgan Richard S. Houlston
author_facet	Ni Li David C. Johnson Niels Weinhold James B. Studd Giulia Orlando Fabio Mirabella Jonathan S. Mitchell Tobias Meissner Martin Kaiser Hartmut Goldschmidt Kari Hemminki Gareth J. Morgan Richard S. Houlston
author_sort	Ni Li
title	Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression
title_short	Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression
title_full	Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression
title_fullStr	Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression
title_full_unstemmed	Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression
title_sort	multiple myeloma risk variant at 7p15.3 creates an irf4-binding site and interferes with cdca7l expression
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/afbf3a5c64704e4682e918800c30d427
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Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression

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