Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children

Abstract Both the innate and adaptive immune responses are deregulated in individuals with obesity and are key drivers of its associated metabolic alterations. Although the anti-inflammatory growth differentiation factor 15 (GDF-15) is a candidate protein against obesity, its mechanisms regulating t...

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Autores principales:	Gemma Carreras-Badosa, Ariadna Gómez-Vilarrubla, Berta Mas-Parés, Silvia Xargay-Torrent, Anna Prats-Puig, Elsa Puerto-Carranza, Francis de Zegher, Lourdes Ibáñez, Judit Bassols, Abel López-Bermejo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/afc41e1885d34a4d89619a9791451d1a
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spelling	oai:doaj.org-article:afc41e1885d34a4d89619a9791451d1a2021-12-02T17:25:43ZLongitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children10.1038/s41598-021-97386-12045-2322https://doaj.org/article/afc41e1885d34a4d89619a9791451d1a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97386-1https://doaj.org/toc/2045-2322Abstract Both the innate and adaptive immune responses are deregulated in individuals with obesity and are key drivers of its associated metabolic alterations. Although the anti-inflammatory growth differentiation factor 15 (GDF-15) is a candidate protein against obesity, its mechanisms regulating the immune responses are not fully cleared. We examined whether GDF-15 was related to serum immunoglobulins in a children’s cohort assessed longitudinally during childhood. Results showed that circulating GDF-15 positively associated with IgA (p < 0.002) and IgG (p < 0.001) levels and the IgAIgG product (p < 0.001) in apparently healthy children at both baseline (age 9) and follow-up (age 13). The associations were readily observed in heavier children (those with BMI-SDS above the median) as well as in children with higher renal fat accumulation (those with renal fat-to-height ratio above the median) and remained significant after correcting for possible confounding variables. Serum GDF-15 levels accounted for up to 16% of the variance of follow-up IgG levels and up to 14% of the variance of follow-up IgAIgG product. The longitudinal associations of the anti-inflammatory GDF-15 with IgA, IgG and the IgA*IgG product in children with higher BMI or higher renal fat accumulation suggest a role of GDF-15 in human obesity through the regulation of the immune adaptive system.Gemma Carreras-BadosaAriadna Gómez-VilarrublaBerta Mas-ParésSilvia Xargay-TorrentAnna Prats-PuigElsa Puerto-CarranzaFrancis de ZegherLourdes IbáñezJudit BassolsAbel López-BermejoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gemma Carreras-Badosa Ariadna Gómez-Vilarrubla Berta Mas-Parés Silvia Xargay-Torrent Anna Prats-Puig Elsa Puerto-Carranza Francis de Zegher Lourdes Ibáñez Judit Bassols Abel López-Bermejo Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children
description	Abstract Both the innate and adaptive immune responses are deregulated in individuals with obesity and are key drivers of its associated metabolic alterations. Although the anti-inflammatory growth differentiation factor 15 (GDF-15) is a candidate protein against obesity, its mechanisms regulating the immune responses are not fully cleared. We examined whether GDF-15 was related to serum immunoglobulins in a children’s cohort assessed longitudinally during childhood. Results showed that circulating GDF-15 positively associated with IgA (p < 0.002) and IgG (p < 0.001) levels and the IgAIgG product (p < 0.001) in apparently healthy children at both baseline (age 9) and follow-up (age 13). The associations were readily observed in heavier children (those with BMI-SDS above the median) as well as in children with higher renal fat accumulation (those with renal fat-to-height ratio above the median) and remained significant after correcting for possible confounding variables. Serum GDF-15 levels accounted for up to 16% of the variance of follow-up IgG levels and up to 14% of the variance of follow-up IgAIgG product. The longitudinal associations of the anti-inflammatory GDF-15 with IgA, IgG and the IgA*IgG product in children with higher BMI or higher renal fat accumulation suggest a role of GDF-15 in human obesity through the regulation of the immune adaptive system.
format	article
author	Gemma Carreras-Badosa Ariadna Gómez-Vilarrubla Berta Mas-Parés Silvia Xargay-Torrent Anna Prats-Puig Elsa Puerto-Carranza Francis de Zegher Lourdes Ibáñez Judit Bassols Abel López-Bermejo
author_facet	Gemma Carreras-Badosa Ariadna Gómez-Vilarrubla Berta Mas-Parés Silvia Xargay-Torrent Anna Prats-Puig Elsa Puerto-Carranza Francis de Zegher Lourdes Ibáñez Judit Bassols Abel López-Bermejo
author_sort	Gemma Carreras-Badosa
title	Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children
title_short	Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children
title_full	Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children
title_fullStr	Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children
title_full_unstemmed	Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children
title_sort	longitudinal association of the anti-inflammatory serum marker gdf-15 with serum iga and igg in apparently healthy children
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/afc41e1885d34a4d89619a9791451d1a
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Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children

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