Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq

Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq

Triple-negative breast cancer is highly heterogeneous and aggressive. Here, the authors utilise single-cell RNA sequencing to investigate this heterogeneity, and discover a subpopulation of cells associated with metastasis and treatment resistance signatures, and linked to long term survival outcome...

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Autores principales: Mihriban Karaayvaz, Simona Cristea, Shawn M. Gillespie, Anoop P. Patel, Ravindra Mylvaganam, Christina C. Luo, Michelle C. Specht, Bradley E. Bernstein, Franziska Michor, Leif W. Ellisen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/afc5c409cf52474faf19d8ea9034f824
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Sumario:Triple-negative breast cancer is highly heterogeneous and aggressive. Here, the authors utilise single-cell RNA sequencing to investigate this heterogeneity, and discover a subpopulation of cells associated with metastasis and treatment resistance signatures, and linked to long term survival outcomes.

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