Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq

Triple-negative breast cancer is highly heterogeneous and aggressive. Here, the authors utilise single-cell RNA sequencing to investigate this heterogeneity, and discover a subpopulation of cells associated with metastasis and treatment resistance signatures, and linked to long term survival outcome...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mihriban Karaayvaz, Simona Cristea, Shawn M. Gillespie, Anoop P. Patel, Ravindra Mylvaganam, Christina C. Luo, Michelle C. Specht, Bradley E. Bernstein, Franziska Michor, Leif W. Ellisen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/afc5c409cf52474faf19d8ea9034f824
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:afc5c409cf52474faf19d8ea9034f824
record_format	dspace
spelling	oai:doaj.org-article:afc5c409cf52474faf19d8ea9034f8242021-12-02T16:49:54ZUnravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq10.1038/s41467-018-06052-02041-1723https://doaj.org/article/afc5c409cf52474faf19d8ea9034f8242018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06052-0https://doaj.org/toc/2041-1723Triple-negative breast cancer is highly heterogeneous and aggressive. Here, the authors utilise single-cell RNA sequencing to investigate this heterogeneity, and discover a subpopulation of cells associated with metastasis and treatment resistance signatures, and linked to long term survival outcomes.Mihriban KaraayvazSimona CristeaShawn M. GillespieAnoop P. PatelRavindra MylvaganamChristina C. LuoMichelle C. SpechtBradley E. BernsteinFranziska MichorLeif W. EllisenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mihriban Karaayvaz Simona Cristea Shawn M. Gillespie Anoop P. Patel Ravindra Mylvaganam Christina C. Luo Michelle C. Specht Bradley E. Bernstein Franziska Michor Leif W. Ellisen Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq
description	Triple-negative breast cancer is highly heterogeneous and aggressive. Here, the authors utilise single-cell RNA sequencing to investigate this heterogeneity, and discover a subpopulation of cells associated with metastasis and treatment resistance signatures, and linked to long term survival outcomes.
format	article
author	Mihriban Karaayvaz Simona Cristea Shawn M. Gillespie Anoop P. Patel Ravindra Mylvaganam Christina C. Luo Michelle C. Specht Bradley E. Bernstein Franziska Michor Leif W. Ellisen
author_facet	Mihriban Karaayvaz Simona Cristea Shawn M. Gillespie Anoop P. Patel Ravindra Mylvaganam Christina C. Luo Michelle C. Specht Bradley E. Bernstein Franziska Michor Leif W. Ellisen
author_sort	Mihriban Karaayvaz
title	Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq
title_short	Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq
title_full	Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq
title_fullStr	Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq
title_full_unstemmed	Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq
title_sort	unravelling subclonal heterogeneity and aggressive disease states in tnbc through single-cell rna-seq
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/afc5c409cf52474faf19d8ea9034f824
work_keys_str_mv	AT mihribankaraayvaz unravellingsubclonalheterogeneityandaggressivediseasestatesintnbcthroughsinglecellrnaseq AT simonacristea unravellingsubclonalheterogeneityandaggressivediseasestatesintnbcthroughsinglecellrnaseq AT shawnmgillespie unravellingsubclonalheterogeneityandaggressivediseasestatesintnbcthroughsinglecellrnaseq AT anoopppatel unravellingsubclonalheterogeneityandaggressivediseasestatesintnbcthroughsinglecellrnaseq AT ravindramylvaganam unravellingsubclonalheterogeneityandaggressivediseasestatesintnbcthroughsinglecellrnaseq AT christinacluo unravellingsubclonalheterogeneityandaggressivediseasestatesintnbcthroughsinglecellrnaseq AT michellecspecht unravellingsubclonalheterogeneityandaggressivediseasestatesintnbcthroughsinglecellrnaseq AT bradleyebernstein unravellingsubclonalheterogeneityandaggressivediseasestatesintnbcthroughsinglecellrnaseq AT franziskamichor unravellingsubclonalheterogeneityandaggressivediseasestatesintnbcthroughsinglecellrnaseq AT leifwellisen unravellingsubclonalheterogeneityandaggressivediseasestatesintnbcthroughsinglecellrnaseq
_version_	1718383179229822976

Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq

Ejemplares similares