Progress of Nanotechnology in Diabetic Retinopathy Treatment

Yuxin Liu,1 Na Wu2,3 1Student Affairs Department, Shengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of China; 2Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of China; 3Clinical Sk...

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Autores principales:	Liu Y, Wu N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	diabetes mellitus diabetic retinopathy nanotechnology drug delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/afc86cfd244e4461ae572aaeb7ed5c93
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spelling	oai:doaj.org-article:afc86cfd244e4461ae572aaeb7ed5c932021-12-02T14:18:12ZProgress of Nanotechnology in Diabetic Retinopathy Treatment1178-2013https://doaj.org/article/afc86cfd244e4461ae572aaeb7ed5c932021-02-01T00:00:00Zhttps://www.dovepress.com/progress-of-nanotechnology-in-diabetic-retinopathy-treatment-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yuxin Liu,1 Na Wu2,3 1Student Affairs Department, Shengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of China; 2Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of China; 3Clinical Skills Practice Teaching Center, Shengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of ChinaCorrespondence: Na WuShengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of ChinaEmail 3441535223@qq.comAbstract: Diabetic retinopathy (DR) is a chronic diabetes complication that progressively manifests itself as blurred vision, eye floaters, distorted vision, and even partial or total loss of vision as a result of retinal detachment in severe cases. Clinically, patients who have undergone variations in the microcirculation of the ocular fundus are treated with laser photocoagulation to improve the circulation of retina; but for patients with macular edema, anti-vascular endothelial growth factor (anti-VEGF) drugs are generally injected to eliminate macular edema and improve vision. The worst cases are patients with fundus hemorrhage or proliferative vitreoretinopathy, for whom vitrectomy has been performed. At present, these clinical treatment methods have widely been used, providing satisfactory results. However, considering the low bioavailability and potential side effects of drugs and the inevitable risks in major surgery, DR prevention, and treatment as well as nerve tissue regeneration in the later stage have always been the focus of research. In recent years, nanotechnology has been increasingly applied in the medical field, leading to new ideas for DR treatment. This study aims to systematically review the research progress of nanotechnology in DR treatment.Keywords: diabetes mellitus, diabetic retinopathy, nanotechnology, drug deliveryLiu YWu NDove Medical Pressarticlediabetes mellitusdiabetic retinopathynanotechnologydrug deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 1391-1403 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus diabetic retinopathy nanotechnology drug delivery Medicine (General) R5-920
spellingShingle	diabetes mellitus diabetic retinopathy nanotechnology drug delivery Medicine (General) R5-920 Liu Y Wu N Progress of Nanotechnology in Diabetic Retinopathy Treatment
description	Yuxin Liu,1 Na Wu2,3 1Student Affairs Department, Shengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of China; 2Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of China; 3Clinical Skills Practice Teaching Center, Shengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of ChinaCorrespondence: Na WuShengjing Hospital of China Medical University, Shenyang, 110004, People’s Republic of ChinaEmail 3441535223@qq.comAbstract: Diabetic retinopathy (DR) is a chronic diabetes complication that progressively manifests itself as blurred vision, eye floaters, distorted vision, and even partial or total loss of vision as a result of retinal detachment in severe cases. Clinically, patients who have undergone variations in the microcirculation of the ocular fundus are treated with laser photocoagulation to improve the circulation of retina; but for patients with macular edema, anti-vascular endothelial growth factor (anti-VEGF) drugs are generally injected to eliminate macular edema and improve vision. The worst cases are patients with fundus hemorrhage or proliferative vitreoretinopathy, for whom vitrectomy has been performed. At present, these clinical treatment methods have widely been used, providing satisfactory results. However, considering the low bioavailability and potential side effects of drugs and the inevitable risks in major surgery, DR prevention, and treatment as well as nerve tissue regeneration in the later stage have always been the focus of research. In recent years, nanotechnology has been increasingly applied in the medical field, leading to new ideas for DR treatment. This study aims to systematically review the research progress of nanotechnology in DR treatment.Keywords: diabetes mellitus, diabetic retinopathy, nanotechnology, drug delivery
format	article
author	Liu Y Wu N
author_facet	Liu Y Wu N
author_sort	Liu Y
title	Progress of Nanotechnology in Diabetic Retinopathy Treatment
title_short	Progress of Nanotechnology in Diabetic Retinopathy Treatment
title_full	Progress of Nanotechnology in Diabetic Retinopathy Treatment
title_fullStr	Progress of Nanotechnology in Diabetic Retinopathy Treatment
title_full_unstemmed	Progress of Nanotechnology in Diabetic Retinopathy Treatment
title_sort	progress of nanotechnology in diabetic retinopathy treatment
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/afc86cfd244e4461ae572aaeb7ed5c93
work_keys_str_mv	AT liuy progressofnanotechnologyindiabeticretinopathytreatment AT wun progressofnanotechnologyindiabeticretinopathytreatment
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Progress of Nanotechnology in Diabetic Retinopathy Treatment

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