Concurrent ductal carcinoma in-situ and malignant phyllodes with tp53 mutation in an 11-year-old

Phyllodes breast tumours are a rare fibroepithelial lesion that rarely occur in the pediatric population. Reports for benign phyllodes tumours have been limited to case series while only two reports have reported borderline or malignant tumours in children. We report the case of an 11-year-old femal...

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Autores principales:	Cameron F. Leveille, Gilgamesh Eamer, Shahistha Sayeda, Sarab Mohamed, Matthew Choi, Nicole Hodgson, Helene Flageole
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Phyllodes tumours Pediatrics Li-fraumeni syndrome Oncoplastic Multi-disciplinary RJ1-570 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/afca3f5f7ce342ecb1dc05e8297ecc01
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spelling	oai:doaj.org-article:afca3f5f7ce342ecb1dc05e8297ecc012021-11-24T04:30:25ZConcurrent ductal carcinoma in-situ and malignant phyllodes with tp53 mutation in an 11-year-old2213-576610.1016/j.epsc.2021.102101https://doaj.org/article/afca3f5f7ce342ecb1dc05e8297ecc012021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213576621003225https://doaj.org/toc/2213-5766Phyllodes breast tumours are a rare fibroepithelial lesion that rarely occur in the pediatric population. Reports for benign phyllodes tumours have been limited to case series while only two reports have reported borderline or malignant tumours in children. We report the case of an 11-year-old female presenting with a borderline malignant phyllodes tumor and associated ductal carcinoma in situ (DCIS). We present an interesting case outlining the pathological assessment, surgical management, reconstruction, and subsequent genetic diagnosis of Li-Fraumeni Syndrome. We discuss the importance of multidisciplinary collaboration required and challenges undergoing treatment of rare pediatric breast cancer. To our knowledge, this is the youngest case of a phyllodes tumor within a DCIS field defect in an adolescent female reported to date.Cameron F. LeveilleGilgamesh EamerShahistha SayedaSarab MohamedMatthew ChoiNicole HodgsonHelene FlageoleElsevierarticlePhyllodes tumoursPediatricsLi-fraumeni syndromeOncoplasticMulti-disciplinaryPediatricsRJ1-570SurgeryRD1-811ENJournal of Pediatric Surgery Case Reports, Vol 75, Iss , Pp 102101- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Phyllodes tumours Pediatrics Li-fraumeni syndrome Oncoplastic Multi-disciplinary Pediatrics RJ1-570 Surgery RD1-811
spellingShingle	Phyllodes tumours Pediatrics Li-fraumeni syndrome Oncoplastic Multi-disciplinary Pediatrics RJ1-570 Surgery RD1-811 Cameron F. Leveille Gilgamesh Eamer Shahistha Sayeda Sarab Mohamed Matthew Choi Nicole Hodgson Helene Flageole Concurrent ductal carcinoma in-situ and malignant phyllodes with tp53 mutation in an 11-year-old
description	Phyllodes breast tumours are a rare fibroepithelial lesion that rarely occur in the pediatric population. Reports for benign phyllodes tumours have been limited to case series while only two reports have reported borderline or malignant tumours in children. We report the case of an 11-year-old female presenting with a borderline malignant phyllodes tumor and associated ductal carcinoma in situ (DCIS). We present an interesting case outlining the pathological assessment, surgical management, reconstruction, and subsequent genetic diagnosis of Li-Fraumeni Syndrome. We discuss the importance of multidisciplinary collaboration required and challenges undergoing treatment of rare pediatric breast cancer. To our knowledge, this is the youngest case of a phyllodes tumor within a DCIS field defect in an adolescent female reported to date.
format	article
author	Cameron F. Leveille Gilgamesh Eamer Shahistha Sayeda Sarab Mohamed Matthew Choi Nicole Hodgson Helene Flageole
author_facet	Cameron F. Leveille Gilgamesh Eamer Shahistha Sayeda Sarab Mohamed Matthew Choi Nicole Hodgson Helene Flageole
author_sort	Cameron F. Leveille
title	Concurrent ductal carcinoma in-situ and malignant phyllodes with tp53 mutation in an 11-year-old
title_short	Concurrent ductal carcinoma in-situ and malignant phyllodes with tp53 mutation in an 11-year-old
title_full	Concurrent ductal carcinoma in-situ and malignant phyllodes with tp53 mutation in an 11-year-old
title_fullStr	Concurrent ductal carcinoma in-situ and malignant phyllodes with tp53 mutation in an 11-year-old
title_full_unstemmed	Concurrent ductal carcinoma in-situ and malignant phyllodes with tp53 mutation in an 11-year-old
title_sort	concurrent ductal carcinoma in-situ and malignant phyllodes with tp53 mutation in an 11-year-old
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/afca3f5f7ce342ecb1dc05e8297ecc01
work_keys_str_mv	AT cameronfleveille concurrentductalcarcinomainsituandmalignantphyllodeswithtp53mutationinan11yearold AT gilgamesheamer concurrentductalcarcinomainsituandmalignantphyllodeswithtp53mutationinan11yearold AT shahisthasayeda concurrentductalcarcinomainsituandmalignantphyllodeswithtp53mutationinan11yearold AT sarabmohamed concurrentductalcarcinomainsituandmalignantphyllodeswithtp53mutationinan11yearold AT matthewchoi concurrentductalcarcinomainsituandmalignantphyllodeswithtp53mutationinan11yearold AT nicolehodgson concurrentductalcarcinomainsituandmalignantphyllodeswithtp53mutationinan11yearold AT heleneflageole concurrentductalcarcinomainsituandmalignantphyllodeswithtp53mutationinan11yearold
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Concurrent ductal carcinoma in-situ and malignant phyllodes with tp53 mutation in an 11-year-old

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