Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease

Multiple myeloma is a cancer of the bone marrow that can induce bone disease. Here, the authors profile the transcriptome of bone-lining cells and find a targetable role of bone morphogenetic protein (BMP) signalling in myeloma-induced bone-disease

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Autores principales:	Sarah Gooding, Sam W. Z. Olechnowicz, Emma V. Morris, Andrew E. Armitage, Joao Arezes, Joe Frost, Emmanouela Repapi, James R. Edwards, Neil Ashley, Craig Waugh, Nicola Gray, Erik Martinez-Hackert, Pei Jin Lim, Sant-Rayn Pasricha, Helen Knowles, Adam J. Mead, Karthik Ramasamy, Hal Drakesmith, Claire M. Edwards
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/afce39d2e8774212826676e3142ffc40
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spelling	oai:doaj.org-article:afce39d2e8774212826676e3142ffc402021-12-02T17:31:53ZTranscriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease10.1038/s41467-019-12296-12041-1723https://doaj.org/article/afce39d2e8774212826676e3142ffc402019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12296-1https://doaj.org/toc/2041-1723Multiple myeloma is a cancer of the bone marrow that can induce bone disease. Here, the authors profile the transcriptome of bone-lining cells and find a targetable role of bone morphogenetic protein (BMP) signalling in myeloma-induced bone-diseaseSarah GoodingSam W. Z. OlechnowiczEmma V. MorrisAndrew E. ArmitageJoao ArezesJoe FrostEmmanouela RepapiJames R. EdwardsNeil AshleyCraig WaughNicola GrayErik Martinez-HackertPei Jin LimSant-Rayn PasrichaHelen KnowlesAdam J. MeadKarthik RamasamyHal DrakesmithClaire M. EdwardsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah Gooding Sam W. Z. Olechnowicz Emma V. Morris Andrew E. Armitage Joao Arezes Joe Frost Emmanouela Repapi James R. Edwards Neil Ashley Craig Waugh Nicola Gray Erik Martinez-Hackert Pei Jin Lim Sant-Rayn Pasricha Helen Knowles Adam J. Mead Karthik Ramasamy Hal Drakesmith Claire M. Edwards Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
description	Multiple myeloma is a cancer of the bone marrow that can induce bone disease. Here, the authors profile the transcriptome of bone-lining cells and find a targetable role of bone morphogenetic protein (BMP) signalling in myeloma-induced bone-disease
format	article
author	Sarah Gooding Sam W. Z. Olechnowicz Emma V. Morris Andrew E. Armitage Joao Arezes Joe Frost Emmanouela Repapi James R. Edwards Neil Ashley Craig Waugh Nicola Gray Erik Martinez-Hackert Pei Jin Lim Sant-Rayn Pasricha Helen Knowles Adam J. Mead Karthik Ramasamy Hal Drakesmith Claire M. Edwards
author_facet	Sarah Gooding Sam W. Z. Olechnowicz Emma V. Morris Andrew E. Armitage Joao Arezes Joe Frost Emmanouela Repapi James R. Edwards Neil Ashley Craig Waugh Nicola Gray Erik Martinez-Hackert Pei Jin Lim Sant-Rayn Pasricha Helen Knowles Adam J. Mead Karthik Ramasamy Hal Drakesmith Claire M. Edwards
author_sort	Sarah Gooding
title	Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
title_short	Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
title_full	Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
title_fullStr	Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
title_full_unstemmed	Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
title_sort	transcriptomic profiling of the myeloma bone-lining niche reveals bmp signalling inhibition to improve bone disease
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/afce39d2e8774212826676e3142ffc40
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Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease

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