The Association Between Interleukin 1 Beta Promoter Polymorphisms And Keratoconus Incidence And Severity In An Egyptian Population

Karim Mahmoud Nabil,1 Ghada Mohamed Elhady,2 Heba Morsy2 1Department of Ophthalmology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt; 2Department of Human Genetics, Medical Research Institute, University of Alexandria, Alexandria, EgyptCorrespondence: Karim Mahmoud NabilDepartment...

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Autores principales:	Nabil KM, Elhady GM, Morsy H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	interleukin 1 beta promoter polymorphisms keratoconus egypt. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/afd07caaa71747669b54d27efc9ace05
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spelling	oai:doaj.org-article:afd07caaa71747669b54d27efc9ace052021-12-02T07:50:02ZThe Association Between Interleukin 1 Beta Promoter Polymorphisms And Keratoconus Incidence And Severity In An Egyptian Population1177-5483https://doaj.org/article/afd07caaa71747669b54d27efc9ace052019-11-01T00:00:00Zhttps://www.dovepress.com/the-association-between-interleukin-1-beta-promoter-polymorphisms-and--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Karim Mahmoud Nabil,1 Ghada Mohamed Elhady,2 Heba Morsy2 1Department of Ophthalmology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt; 2Department of Human Genetics, Medical Research Institute, University of Alexandria, Alexandria, EgyptCorrespondence: Karim Mahmoud NabilDepartment of Ophthalmology, Faculty of Medicine, University of Alexandria, Sultan Hussein Street, Khartoum Square, Alexandria 21523, EgyptTel +2034869545Fax +2034255781Email Karim_nabil_ophth@yahoo.comPurpose: In the present study, we investigated whether interleukin 1 beta (IL1B) promoter polymorphisms are associated with keratoconus in an Egyptian population and their association with disease severity.Methods: A total of 95 Egyptian keratoconus patients and 126 Egyptian healthy controls were enrolled in the study. Two IL1B single nucleotide polymorphisms (SNPs) (rs1143627 and rs16944) were genotyped using Taqman real-time PCR to compare haplotype, genotype, and allele frequencies between cases and controls (primary outcome) and their association with disease severity (secondary outcome).Results: Statistically significant association was observed for rs1143627 and rs16944; the T allele of rs1143627 and the G allele of rs16944 were associated with an increased risk of keratoconus (p < 0.001, odds ratio = 3.313, 4.770, respectively). The TT genotype of rs1143627 and the GG genotype of rs16944 were strongly associated with an increased risk of keratoconus (p < 0.001, odds ratio = 5.631, 11.478, respectively). The G allele of rs16944 was associated with an increased curvature of the flattest corneal meridian Kf in keratoconus (p = 0.041). The GG genotype of rs16944 was associated with an increased curvature of the flattest corneal meridian Kf, steepest corneal meridian Ks and average corneal curvature Kavg in keratoconus (p = 0.01, 0.046, 0.023, respectively).Conclusion: IL1B is suspected to play a crucial role, both in development and severity of keratoconus in Egyptian population.Keywords: interleukin 1 beta, promoter polymorphisms, keratoconus, EgyptNabil KMElhady GMMorsy HDove Medical Pressarticleinterleukin 1 betapromoter polymorphismskeratoconusegypt.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 2217-2223 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	interleukin 1 beta promoter polymorphisms keratoconus egypt. Ophthalmology RE1-994
spellingShingle	interleukin 1 beta promoter polymorphisms keratoconus egypt. Ophthalmology RE1-994 Nabil KM Elhady GM Morsy H The Association Between Interleukin 1 Beta Promoter Polymorphisms And Keratoconus Incidence And Severity In An Egyptian Population
description	Karim Mahmoud Nabil,1 Ghada Mohamed Elhady,2 Heba Morsy2 1Department of Ophthalmology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt; 2Department of Human Genetics, Medical Research Institute, University of Alexandria, Alexandria, EgyptCorrespondence: Karim Mahmoud NabilDepartment of Ophthalmology, Faculty of Medicine, University of Alexandria, Sultan Hussein Street, Khartoum Square, Alexandria 21523, EgyptTel +2034869545Fax +2034255781Email Karim_nabil_ophth@yahoo.comPurpose: In the present study, we investigated whether interleukin 1 beta (IL1B) promoter polymorphisms are associated with keratoconus in an Egyptian population and their association with disease severity.Methods: A total of 95 Egyptian keratoconus patients and 126 Egyptian healthy controls were enrolled in the study. Two IL1B single nucleotide polymorphisms (SNPs) (rs1143627 and rs16944) were genotyped using Taqman real-time PCR to compare haplotype, genotype, and allele frequencies between cases and controls (primary outcome) and their association with disease severity (secondary outcome).Results: Statistically significant association was observed for rs1143627 and rs16944; the T allele of rs1143627 and the G allele of rs16944 were associated with an increased risk of keratoconus (p < 0.001, odds ratio = 3.313, 4.770, respectively). The TT genotype of rs1143627 and the GG genotype of rs16944 were strongly associated with an increased risk of keratoconus (p < 0.001, odds ratio = 5.631, 11.478, respectively). The G allele of rs16944 was associated with an increased curvature of the flattest corneal meridian Kf in keratoconus (p = 0.041). The GG genotype of rs16944 was associated with an increased curvature of the flattest corneal meridian Kf, steepest corneal meridian Ks and average corneal curvature Kavg in keratoconus (p = 0.01, 0.046, 0.023, respectively).Conclusion: IL1B is suspected to play a crucial role, both in development and severity of keratoconus in Egyptian population.Keywords: interleukin 1 beta, promoter polymorphisms, keratoconus, Egypt
format	article
author	Nabil KM Elhady GM Morsy H
author_facet	Nabil KM Elhady GM Morsy H
author_sort	Nabil KM
title	The Association Between Interleukin 1 Beta Promoter Polymorphisms And Keratoconus Incidence And Severity In An Egyptian Population
title_short	The Association Between Interleukin 1 Beta Promoter Polymorphisms And Keratoconus Incidence And Severity In An Egyptian Population
title_full	The Association Between Interleukin 1 Beta Promoter Polymorphisms And Keratoconus Incidence And Severity In An Egyptian Population
title_fullStr	The Association Between Interleukin 1 Beta Promoter Polymorphisms And Keratoconus Incidence And Severity In An Egyptian Population
title_full_unstemmed	The Association Between Interleukin 1 Beta Promoter Polymorphisms And Keratoconus Incidence And Severity In An Egyptian Population
title_sort	association between interleukin 1 beta promoter polymorphisms and keratoconus incidence and severity in an egyptian population
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/afd07caaa71747669b54d27efc9ace05
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The Association Between Interleukin 1 Beta Promoter Polymorphisms And Keratoconus Incidence And Severity In An Egyptian Population

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