Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon

Malaria is still a threat to public health as it remains the first endemic disease in the world. It is a pervasive parasitic disease in tropical and subtropical regions where asymptomatic malaria infection among humans serves as a significant reservoir for transmission. A rapid and correct diagnosis...

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Autores principales:	Nji Mbuh Akindeh, Lesley Ngum Ngum, Peter Thelma Ngwa Niba, Innocent Mbulli Ali, Ornella Laetitia Oben Ayem, Jean Paul Kengne Chedjou, Calvino Tah Fomboh, Aristid Herve Mbange Ekollo, Cyrille Mbanwi Mbu’u, Wilfred Fon Mbacham
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	asymptomatic malaria children prevalence <i>Plasmodium</i> species Yaoundé Cameroon Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/afd194362a77404fa4a2d70606da023a
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spelling	oai:doaj.org-article:afd194362a77404fa4a2d70606da023a2021-11-25T17:13:56ZAssessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon10.3390/children81109602227-9067https://doaj.org/article/afd194362a77404fa4a2d70606da023a2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9067/8/11/960https://doaj.org/toc/2227-9067Malaria is still a threat to public health as it remains the first endemic disease in the world. It is a pervasive parasitic disease in tropical and subtropical regions where asymptomatic malaria infection among humans serves as a significant reservoir for transmission. A rapid and correct diagnosis is considered to be an important strategy in the control of the disease especially in children, who are the most vulnerable group. This study assessed the prevalence of asymptomatic malaria in children at the Nkolbisson health area in Yaoundé, Cameroon. A cross-sectional study design and a convenience sampling plan were used. A total of 127 participants were recruited after informed and signed consent from parents and/or guardians. Blood samples were collected by finger-pricking and venipuncture from children aged 6 months to 10 years and then screened for asymptomatic parasitemia by a rapid diagnostic test (RDT), light microscopy (LM) staining with Giemsa and 18S rRNA polymerase chain reaction (PCR) for speciation. The data were analyzed using SPSS version 20 software. The study identified 85 children who were positive from the PCR, 95 positive from the RDT and 71 from the LM, revealing a malaria prevalence of 66.9%, 74.8% and 55.9%, respectively. The prevalence was not observed to be dependent on the sex and age group of the participants. <i>Plasmodium falciparum</i> was the predominant species followed by <i>Plasmodium malariae</i> and then <i>Plasmodium ovale</i>. The RDT and LM had the same sensitivity (90.6%) with a slight difference in their specificity (RDT: 57.1%; LM: 54.8%). The RDT also demonstrated higher positive and negative predictive values compared with those of the LM.Nji Mbuh AkindehLesley Ngum NgumPeter Thelma Ngwa NibaInnocent Mbulli AliOrnella Laetitia Oben AyemJean Paul Kengne ChedjouCalvino Tah FombohAristid Herve Mbange EkolloCyrille Mbanwi Mbu’uWilfred Fon MbachamMDPI AGarticleasymptomatic malariachildren prevalence<i>Plasmodium</i> speciesYaoundéCameroonPediatricsRJ1-570ENChildren, Vol 8, Iss 960, p 960 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	asymptomatic malaria children prevalence <i>Plasmodium</i> species Yaoundé Cameroon Pediatrics RJ1-570
spellingShingle	asymptomatic malaria children prevalence <i>Plasmodium</i> species Yaoundé Cameroon Pediatrics RJ1-570 Nji Mbuh Akindeh Lesley Ngum Ngum Peter Thelma Ngwa Niba Innocent Mbulli Ali Ornella Laetitia Oben Ayem Jean Paul Kengne Chedjou Calvino Tah Fomboh Aristid Herve Mbange Ekollo Cyrille Mbanwi Mbu’u Wilfred Fon Mbacham Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon
description	Malaria is still a threat to public health as it remains the first endemic disease in the world. It is a pervasive parasitic disease in tropical and subtropical regions where asymptomatic malaria infection among humans serves as a significant reservoir for transmission. A rapid and correct diagnosis is considered to be an important strategy in the control of the disease especially in children, who are the most vulnerable group. This study assessed the prevalence of asymptomatic malaria in children at the Nkolbisson health area in Yaoundé, Cameroon. A cross-sectional study design and a convenience sampling plan were used. A total of 127 participants were recruited after informed and signed consent from parents and/or guardians. Blood samples were collected by finger-pricking and venipuncture from children aged 6 months to 10 years and then screened for asymptomatic parasitemia by a rapid diagnostic test (RDT), light microscopy (LM) staining with Giemsa and 18S rRNA polymerase chain reaction (PCR) for speciation. The data were analyzed using SPSS version 20 software. The study identified 85 children who were positive from the PCR, 95 positive from the RDT and 71 from the LM, revealing a malaria prevalence of 66.9%, 74.8% and 55.9%, respectively. The prevalence was not observed to be dependent on the sex and age group of the participants. <i>Plasmodium falciparum</i> was the predominant species followed by <i>Plasmodium malariae</i> and then <i>Plasmodium ovale</i>. The RDT and LM had the same sensitivity (90.6%) with a slight difference in their specificity (RDT: 57.1%; LM: 54.8%). The RDT also demonstrated higher positive and negative predictive values compared with those of the LM.
format	article
author	Nji Mbuh Akindeh Lesley Ngum Ngum Peter Thelma Ngwa Niba Innocent Mbulli Ali Ornella Laetitia Oben Ayem Jean Paul Kengne Chedjou Calvino Tah Fomboh Aristid Herve Mbange Ekollo Cyrille Mbanwi Mbu’u Wilfred Fon Mbacham
author_facet	Nji Mbuh Akindeh Lesley Ngum Ngum Peter Thelma Ngwa Niba Innocent Mbulli Ali Ornella Laetitia Oben Ayem Jean Paul Kengne Chedjou Calvino Tah Fomboh Aristid Herve Mbange Ekollo Cyrille Mbanwi Mbu’u Wilfred Fon Mbacham
author_sort	Nji Mbuh Akindeh
title	Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon
title_short	Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon
title_full	Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon
title_fullStr	Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon
title_full_unstemmed	Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon
title_sort	assessing asymptomatic malaria carriage of <i>plasmodium falciparum</i> and non-<i>falciparum</i> species in children resident in nkolbisson, yaoundé, cameroon
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/afd194362a77404fa4a2d70606da023a
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Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon

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