A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke
Mutations in ryanodine receptor 1 (RyR1), a Ca2+ release channel in skeletal muscle, cause malignant hyperthermia (MH) and are involved in heat stroke. Here, the authors show that an oxolinic acid-derivative RyR1 inhibitor effectively prevents and treats MH and heat stroke in various MH mouse models...
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Nature Portfolio
2021
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oai:doaj.org-article:afd2999f767e49b494c83b5f5e5c1a4b2021-12-02T17:01:15ZA novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke10.1038/s41467-021-24644-12041-1723https://doaj.org/article/afd2999f767e49b494c83b5f5e5c1a4b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24644-1https://doaj.org/toc/2041-1723Mutations in ryanodine receptor 1 (RyR1), a Ca2+ release channel in skeletal muscle, cause malignant hyperthermia (MH) and are involved in heat stroke. Here, the authors show that an oxolinic acid-derivative RyR1 inhibitor effectively prevents and treats MH and heat stroke in various MH mouse models.Toshiko YamazawaTakuya KobayashiNagomi KurebayashiMasato KonishiSatoru NoguchiTakayoshi InoueYukiko U. InoueIchizo NishinoShuichi MoriHiroto IinumaNoriaki ManakaHiroyuki KagechikaArkady UryashJose AdamsJose R. LopezXiaochen LiuChristine DigglePaul D. AllenSho KakizawaKeigo IkedaBangzhong LinYui IkemiKazuto NunomuraShinsaku NakagawaTakashi SakuraiTakashi MurayamaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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Science Q Toshiko Yamazawa Takuya Kobayashi Nagomi Kurebayashi Masato Konishi Satoru Noguchi Takayoshi Inoue Yukiko U. Inoue Ichizo Nishino Shuichi Mori Hiroto Iinuma Noriaki Manaka Hiroyuki Kagechika Arkady Uryash Jose Adams Jose R. Lopez Xiaochen Liu Christine Diggle Paul D. Allen Sho Kakizawa Keigo Ikeda Bangzhong Lin Yui Ikemi Kazuto Nunomura Shinsaku Nakagawa Takashi Sakurai Takashi Murayama A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke |
| description |
Mutations in ryanodine receptor 1 (RyR1), a Ca2+ release channel in skeletal muscle, cause malignant hyperthermia (MH) and are involved in heat stroke. Here, the authors show that an oxolinic acid-derivative RyR1 inhibitor effectively prevents and treats MH and heat stroke in various MH mouse models. |
| format |
article |
| author |
Toshiko Yamazawa Takuya Kobayashi Nagomi Kurebayashi Masato Konishi Satoru Noguchi Takayoshi Inoue Yukiko U. Inoue Ichizo Nishino Shuichi Mori Hiroto Iinuma Noriaki Manaka Hiroyuki Kagechika Arkady Uryash Jose Adams Jose R. Lopez Xiaochen Liu Christine Diggle Paul D. Allen Sho Kakizawa Keigo Ikeda Bangzhong Lin Yui Ikemi Kazuto Nunomura Shinsaku Nakagawa Takashi Sakurai Takashi Murayama |
| author_facet |
Toshiko Yamazawa Takuya Kobayashi Nagomi Kurebayashi Masato Konishi Satoru Noguchi Takayoshi Inoue Yukiko U. Inoue Ichizo Nishino Shuichi Mori Hiroto Iinuma Noriaki Manaka Hiroyuki Kagechika Arkady Uryash Jose Adams Jose R. Lopez Xiaochen Liu Christine Diggle Paul D. Allen Sho Kakizawa Keigo Ikeda Bangzhong Lin Yui Ikemi Kazuto Nunomura Shinsaku Nakagawa Takashi Sakurai Takashi Murayama |
| author_sort |
Toshiko Yamazawa |
| title |
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke |
| title_short |
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke |
| title_full |
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke |
| title_fullStr |
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke |
| title_full_unstemmed |
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke |
| title_sort |
novel ryr1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/afd2999f767e49b494c83b5f5e5c1a4b |
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