Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation

Abstract In 2006, mutations in the granulin gene were identified in patients with familial Frontotemporal Lobar Degeneration. Granulin transcript haploinsufficiency has been proposed as a disease mechanism that leads to the loss of functional progranulin protein. Granulin mutations were initially fo...

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Autores principales: Masato Hosokawa, Hiromi Kondo, Geidy E. Serrano, Thomas G. Beach, Andrew C. Robinson, David M. Mann, Haruhiko Akiyama, Masato Hasegawa, Tetsuaki Arai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/afd44deb62a8416980a2d0acb1a3fb39
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