Abnormal intrinsic brain activities in stable patients with COPD: a resting-state functional MRI study

Wenjing Wang,1,* Haijun Li,2,* Dechang Peng,2 Juan Luo,1 Huizhen Xin,2 Honghui Yu,2 Jingjing Yu1 1Department of Respiratory, The First Affiliated Hospital of Nanchang University, Nanchang, China; 2Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China *These...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang W, Li H, Peng D, Luo J, Xin H, Yu H, Yu J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	chronic obstructive pulmonary desease amplitude of low-frequency ﬂuctuation functional magnetic resonance imaging spontaneous brain activity blood oxygen-level-dependent. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/afd49d37368745368f25986e96c2d062
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:afd49d37368745368f25986e96c2d062
record_format	dspace
spelling	oai:doaj.org-article:afd49d37368745368f25986e96c2d0622021-12-02T06:23:56ZAbnormal intrinsic brain activities in stable patients with COPD: a resting-state functional MRI study1178-2021https://doaj.org/article/afd49d37368745368f25986e96c2d0622018-10-01T00:00:00Zhttps://www.dovepress.com/abnormal-intrinsic-brain-activities-in-stable-patients-with-copd-a-res-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Wenjing Wang,1,* Haijun Li,2,* Dechang Peng,2 Juan Luo,1 Huizhen Xin,2 Honghui Yu,2 Jingjing Yu1 1Department of Respiratory, The First Affiliated Hospital of Nanchang University, Nanchang, China; 2Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China *These authors contributed equally to this work Objective: The majority of previous neuroimaging studies have reported both structural and functional changes in COPD, whereas the intrinsic low-frequency oscillations changes and the relationship between the abnormal brain regions and the clinical performances remain unknown. The present study was conducted with the aim of evaluating the intrinsic brain activity in COPD patients using the amplitude of low-frequency fluctuation (ALFF) method.Methods: All participants, including 19 stable patients with COPD and 20 normal controls (NCs) matched in age, sex, and education, underwent resting-state functional MRI scans and performed cognitive function tests and respiratory functions tests. The local spontaneous brain activity was examined using the voxel-wise ALFF. Pearson’s correlation analysis was used to investigate the relationships between the brain regions with altered ALFF signal values and the clinical features in COPD patients.Results: Compared with the NCs, COPD patients showed significantly lower cognitive function scores. Also, lower ALFF areas in the cluster of the posterior cingulate cortex (PCC) and precuneus, as well as a higher ALFF area in the brainstem were also found in COPD patients. The mean ALFF values in the PCC, precuneus, and brainstem showed high sensitivity and specificity in operating characteristic curves analysis, which might have the ability to distinguish COPD from NCs. Meanwhile, the mean signal values of the lower ALFF cluster displayed significant positive correlations with FEV1/FVC proportion and significant negative correlation with PaCO2; the higher ALFF cluster showed significant positive correlation with FEV1 proportion in COPD.Conclusion: According to the results of the present study, the COPD patients showed abnormal intrinsic brain activities in the precuneus, PCC, and brainstem, which might provide useful information to better understand the underlying pathophysiology of cognitive impairment. Keywords: chronic obstructive pulmonary disease, amplitude of low-frequency fluctuation, functional magnetic resonance imaging, spontaneous brain activity, blood-oxygen-level dependentWang WLi HPeng DLuo JXin HYu HYu JDove Medical Pressarticlechronic obstructive pulmonary deseaseamplitude of low-frequency ﬂuctuationfunctional magnetic resonance imagingspontaneous brain activityblood oxygen-level-dependent.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2763-2772 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic obstructive pulmonary desease amplitude of low-frequency ﬂuctuation functional magnetic resonance imaging spontaneous brain activity blood oxygen-level-dependent. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	chronic obstructive pulmonary desease amplitude of low-frequency ﬂuctuation functional magnetic resonance imaging spontaneous brain activity blood oxygen-level-dependent. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wang W Li H Peng D Luo J Xin H Yu H Yu J Abnormal intrinsic brain activities in stable patients with COPD: a resting-state functional MRI study
description	Wenjing Wang,1,* Haijun Li,2,* Dechang Peng,2 Juan Luo,1 Huizhen Xin,2 Honghui Yu,2 Jingjing Yu1 1Department of Respiratory, The First Affiliated Hospital of Nanchang University, Nanchang, China; 2Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China *These authors contributed equally to this work Objective: The majority of previous neuroimaging studies have reported both structural and functional changes in COPD, whereas the intrinsic low-frequency oscillations changes and the relationship between the abnormal brain regions and the clinical performances remain unknown. The present study was conducted with the aim of evaluating the intrinsic brain activity in COPD patients using the amplitude of low-frequency fluctuation (ALFF) method.Methods: All participants, including 19 stable patients with COPD and 20 normal controls (NCs) matched in age, sex, and education, underwent resting-state functional MRI scans and performed cognitive function tests and respiratory functions tests. The local spontaneous brain activity was examined using the voxel-wise ALFF. Pearson’s correlation analysis was used to investigate the relationships between the brain regions with altered ALFF signal values and the clinical features in COPD patients.Results: Compared with the NCs, COPD patients showed significantly lower cognitive function scores. Also, lower ALFF areas in the cluster of the posterior cingulate cortex (PCC) and precuneus, as well as a higher ALFF area in the brainstem were also found in COPD patients. The mean ALFF values in the PCC, precuneus, and brainstem showed high sensitivity and specificity in operating characteristic curves analysis, which might have the ability to distinguish COPD from NCs. Meanwhile, the mean signal values of the lower ALFF cluster displayed significant positive correlations with FEV1/FVC proportion and significant negative correlation with PaCO2; the higher ALFF cluster showed significant positive correlation with FEV1 proportion in COPD.Conclusion: According to the results of the present study, the COPD patients showed abnormal intrinsic brain activities in the precuneus, PCC, and brainstem, which might provide useful information to better understand the underlying pathophysiology of cognitive impairment. Keywords: chronic obstructive pulmonary disease, amplitude of low-frequency fluctuation, functional magnetic resonance imaging, spontaneous brain activity, blood-oxygen-level dependent
format	article
author	Wang W Li H Peng D Luo J Xin H Yu H Yu J
author_facet	Wang W Li H Peng D Luo J Xin H Yu H Yu J
author_sort	Wang W
title	Abnormal intrinsic brain activities in stable patients with COPD: a resting-state functional MRI study
title_short	Abnormal intrinsic brain activities in stable patients with COPD: a resting-state functional MRI study
title_full	Abnormal intrinsic brain activities in stable patients with COPD: a resting-state functional MRI study
title_fullStr	Abnormal intrinsic brain activities in stable patients with COPD: a resting-state functional MRI study
title_full_unstemmed	Abnormal intrinsic brain activities in stable patients with COPD: a resting-state functional MRI study
title_sort	abnormal intrinsic brain activities in stable patients with copd: a resting-state functional mri study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/afd49d37368745368f25986e96c2d062
work_keys_str_mv	AT wangw abnormalintrinsicbrainactivitiesinstablepatientswithcopdarestingstatefunctionalmristudy AT lih abnormalintrinsicbrainactivitiesinstablepatientswithcopdarestingstatefunctionalmristudy AT pengd abnormalintrinsicbrainactivitiesinstablepatientswithcopdarestingstatefunctionalmristudy AT luoj abnormalintrinsicbrainactivitiesinstablepatientswithcopdarestingstatefunctionalmristudy AT xinh abnormalintrinsicbrainactivitiesinstablepatientswithcopdarestingstatefunctionalmristudy AT yuh abnormalintrinsicbrainactivitiesinstablepatientswithcopdarestingstatefunctionalmristudy AT yuj abnormalintrinsicbrainactivitiesinstablepatientswithcopdarestingstatefunctionalmristudy
_version_	1718399956673363968

Abnormal intrinsic brain activities in stable patients with COPD: a resting-state functional MRI study

Ejemplares similares