A multicenter study of interocular symmetry of corneal biometrics in Chinese myopic patients

Abstract It is essential to know the normal range of the interocular symmetry of the cornea (ISC) for keratoconus diagnosis and corneal substitutes design. In the present study we investigated the interocular symmetry of corneal biometrics in 6,644 Chinese myopic patients from multiple ophthalmic ce...

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Autores principales:	Guihua Xu, Yijun Hu, Shanqing Zhu, Yunxiang Guo, Lu Xiong, Xuejun Fang, Jia Liu, Qingsong Zhang, Na Huang, Jin Zhou, Fangfang Li, Xiaohua Lei, Li Jiang, Zheng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/afd4df0df0cc443483aabb56900a629c
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spelling	oai:doaj.org-article:afd4df0df0cc443483aabb56900a629c2021-12-02T11:35:58ZA multicenter study of interocular symmetry of corneal biometrics in Chinese myopic patients10.1038/s41598-021-84937-92045-2322https://doaj.org/article/afd4df0df0cc443483aabb56900a629c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84937-9https://doaj.org/toc/2045-2322Abstract It is essential to know the normal range of the interocular symmetry of the cornea (ISC) for keratoconus diagnosis and corneal substitutes design. In the present study we investigated the interocular symmetry of corneal biometrics in 6,644 Chinese myopic patients from multiple ophthalmic centers. Corneal biometrics of both eyes were exported from the Pentacam instrument. Interocular symmetry of the corneal biometrics was analyzed by Spearman’s correlation test, intraclass correlation coefficient (ICC) analysis and Bland–Altman plot. Significantly strong interocular correlations were found in anterior and posterior corneal curvatures, corneal diameter, corneal thickness, corneal volume, corneal eccentricity, and corneal asphericity (r = 0.87–0.98, all P < 0.001). Moderate interocular correlations were observed in whole corneal astigmatism (r = 0.78) and posterior corneal astigmatism (r = 0.73). ICC between the right and left eyes was 0.94–0.98 for anterior and posterior corneal curvatures, corneal diameter, corneal thickness and corneal volume, 0.80–0.88 for corneal eccentricity and asphericity, and 0.73–0.79 for corneal astigmatism (all P < 0.001). Bland–Altman plot showed that the 95% limit of agreement between both eyes was narrow and symmetric in most of the corneal biometrics, suggesting strong interocular agreements in these corneal biometrics. In conclusion, significant interocular symmetry of corneal biometrics is observed in Chinese myopia patients. Extra attention should be paid to patients with interocular corneal asymmetry.Guihua XuYijun HuShanqing ZhuYunxiang GuoLu XiongXuejun FangJia LiuQingsong ZhangNa HuangJin ZhouFangfang LiXiaohua LeiLi JiangZheng WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guihua Xu Yijun Hu Shanqing Zhu Yunxiang Guo Lu Xiong Xuejun Fang Jia Liu Qingsong Zhang Na Huang Jin Zhou Fangfang Li Xiaohua Lei Li Jiang Zheng Wang A multicenter study of interocular symmetry of corneal biometrics in Chinese myopic patients
description	Abstract It is essential to know the normal range of the interocular symmetry of the cornea (ISC) for keratoconus diagnosis and corneal substitutes design. In the present study we investigated the interocular symmetry of corneal biometrics in 6,644 Chinese myopic patients from multiple ophthalmic centers. Corneal biometrics of both eyes were exported from the Pentacam instrument. Interocular symmetry of the corneal biometrics was analyzed by Spearman’s correlation test, intraclass correlation coefficient (ICC) analysis and Bland–Altman plot. Significantly strong interocular correlations were found in anterior and posterior corneal curvatures, corneal diameter, corneal thickness, corneal volume, corneal eccentricity, and corneal asphericity (r = 0.87–0.98, all P < 0.001). Moderate interocular correlations were observed in whole corneal astigmatism (r = 0.78) and posterior corneal astigmatism (r = 0.73). ICC between the right and left eyes was 0.94–0.98 for anterior and posterior corneal curvatures, corneal diameter, corneal thickness and corneal volume, 0.80–0.88 for corneal eccentricity and asphericity, and 0.73–0.79 for corneal astigmatism (all P < 0.001). Bland–Altman plot showed that the 95% limit of agreement between both eyes was narrow and symmetric in most of the corneal biometrics, suggesting strong interocular agreements in these corneal biometrics. In conclusion, significant interocular symmetry of corneal biometrics is observed in Chinese myopia patients. Extra attention should be paid to patients with interocular corneal asymmetry.
format	article
author	Guihua Xu Yijun Hu Shanqing Zhu Yunxiang Guo Lu Xiong Xuejun Fang Jia Liu Qingsong Zhang Na Huang Jin Zhou Fangfang Li Xiaohua Lei Li Jiang Zheng Wang
author_facet	Guihua Xu Yijun Hu Shanqing Zhu Yunxiang Guo Lu Xiong Xuejun Fang Jia Liu Qingsong Zhang Na Huang Jin Zhou Fangfang Li Xiaohua Lei Li Jiang Zheng Wang
author_sort	Guihua Xu
title	A multicenter study of interocular symmetry of corneal biometrics in Chinese myopic patients
title_short	A multicenter study of interocular symmetry of corneal biometrics in Chinese myopic patients
title_full	A multicenter study of interocular symmetry of corneal biometrics in Chinese myopic patients
title_fullStr	A multicenter study of interocular symmetry of corneal biometrics in Chinese myopic patients
title_full_unstemmed	A multicenter study of interocular symmetry of corneal biometrics in Chinese myopic patients
title_sort	multicenter study of interocular symmetry of corneal biometrics in chinese myopic patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/afd4df0df0cc443483aabb56900a629c
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A multicenter study of interocular symmetry of corneal biometrics in Chinese myopic patients

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