Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease

Cellular adhesive connections directed by the extracellular matrix (ECM) and maintenance of cellular homeostasis by autophagy are seemingly disparate functions that are molecularly intertwined, each regulating the other. This is an emerging field in the brain where the interplay between adhesion and...

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Autores principales:	Sarah J. Hernandez, Gianna Fote, Andrea M. Reyes-Ortiz, Joan S. Steffan, Leslie M. Thompson
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Adhesion Autophagy Extracellular matrix Huntington’s disease Integrin Neurodegenerative disease Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/afd54e2517e9412daf298e30dcc82d7b
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spelling	oai:doaj.org-article:afd54e2517e9412daf298e30dcc82d7b2021-11-04T04:39:05ZCooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease2590-028510.1016/j.mbplus.2021.100089https://doaj.org/article/afd54e2517e9412daf298e30dcc82d7b2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590028521000338https://doaj.org/toc/2590-0285Cellular adhesive connections directed by the extracellular matrix (ECM) and maintenance of cellular homeostasis by autophagy are seemingly disparate functions that are molecularly intertwined, each regulating the other. This is an emerging field in the brain where the interplay between adhesion and autophagy functions at the intersection of neuroprotection and neurodegeneration. The ECM and adhesion proteins regulate autophagic responses to direct protein clearance and guide regenerative programs that go awry in brain disorders. Concomitantly, autophagic flux acts to regulate adhesion dynamics to mediate neurite outgrowth and synaptic plasticity with functional disruption contributed by neurodegenerative disease. This review highlights the cooperative exchange between cellular adhesion and autophagy in the brain during health and disease. As the mechanistic alliance between adhesion and autophagy has been leveraged therapeutically for metastatic disease, understanding overlapping molecular functions that direct the interplay between adhesion and autophagy might uncover therapeutic strategies to correct or compensate for neurodegeneration.Sarah J. HernandezGianna FoteAndrea M. Reyes-OrtizJoan S. SteffanLeslie M. ThompsonElsevierarticleAdhesionAutophagyExtracellular matrixHuntington’s diseaseIntegrinNeurodegenerative diseaseBiology (General)QH301-705.5ENMatrix Biology Plus, Vol 12, Iss , Pp 100089- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Adhesion Autophagy Extracellular matrix Huntington’s disease Integrin Neurodegenerative disease Biology (General) QH301-705.5
spellingShingle	Adhesion Autophagy Extracellular matrix Huntington’s disease Integrin Neurodegenerative disease Biology (General) QH301-705.5 Sarah J. Hernandez Gianna Fote Andrea M. Reyes-Ortiz Joan S. Steffan Leslie M. Thompson Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease
description	Cellular adhesive connections directed by the extracellular matrix (ECM) and maintenance of cellular homeostasis by autophagy are seemingly disparate functions that are molecularly intertwined, each regulating the other. This is an emerging field in the brain where the interplay between adhesion and autophagy functions at the intersection of neuroprotection and neurodegeneration. The ECM and adhesion proteins regulate autophagic responses to direct protein clearance and guide regenerative programs that go awry in brain disorders. Concomitantly, autophagic flux acts to regulate adhesion dynamics to mediate neurite outgrowth and synaptic plasticity with functional disruption contributed by neurodegenerative disease. This review highlights the cooperative exchange between cellular adhesion and autophagy in the brain during health and disease. As the mechanistic alliance between adhesion and autophagy has been leveraged therapeutically for metastatic disease, understanding overlapping molecular functions that direct the interplay between adhesion and autophagy might uncover therapeutic strategies to correct or compensate for neurodegeneration.
format	article
author	Sarah J. Hernandez Gianna Fote Andrea M. Reyes-Ortiz Joan S. Steffan Leslie M. Thompson
author_facet	Sarah J. Hernandez Gianna Fote Andrea M. Reyes-Ortiz Joan S. Steffan Leslie M. Thompson
author_sort	Sarah J. Hernandez
title	Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease
title_short	Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease
title_full	Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease
title_fullStr	Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease
title_full_unstemmed	Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease
title_sort	cooperation of cell adhesion and autophagy in the brain: functional roles in development and neurodegenerative disease
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/afd54e2517e9412daf298e30dcc82d7b
work_keys_str_mv	AT sarahjhernandez cooperationofcelladhesionandautophagyinthebrainfunctionalrolesindevelopmentandneurodegenerativedisease AT giannafote cooperationofcelladhesionandautophagyinthebrainfunctionalrolesindevelopmentandneurodegenerativedisease AT andreamreyesortiz cooperationofcelladhesionandautophagyinthebrainfunctionalrolesindevelopmentandneurodegenerativedisease AT joanssteffan cooperationofcelladhesionandautophagyinthebrainfunctionalrolesindevelopmentandneurodegenerativedisease AT lesliemthompson cooperationofcelladhesionandautophagyinthebrainfunctionalrolesindevelopmentandneurodegenerativedisease
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Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease

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