Hospitalization rates for complications due to systemic therapy in the United States

Abstract The aim of this study was to estimate the trends and burdens associated with systemic therapy-related hospitalizations, using nationally representative data. National Inpatient Sample data from 2005 to 2016 was used to identify systemic therapy-related complications using ICD-9 and ICD-10 e...

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Autores principales:	Anshul Saxena, Muni Rubens, Venkataraghavan Ramamoorthy, Raees Tonse, Emir Veledar, Peter McGranaghan, Subrina Sundil, Michael D. Chuong, Matthew D. Hall, Yazmin Odia, Minesh P. Mehta, Rupesh Kotecha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/afd9010f1ae240c388ec4e1b88344d0c
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spelling	oai:doaj.org-article:afd9010f1ae240c388ec4e1b88344d0c2021-12-02T13:26:32ZHospitalization rates for complications due to systemic therapy in the United States10.1038/s41598-021-86911-x2045-2322https://doaj.org/article/afd9010f1ae240c388ec4e1b88344d0c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86911-xhttps://doaj.org/toc/2045-2322Abstract The aim of this study was to estimate the trends and burdens associated with systemic therapy-related hospitalizations, using nationally representative data. National Inpatient Sample data from 2005 to 2016 was used to identify systemic therapy-related complications using ICD-9 and ICD-10 external causes-of-injury codes. The primary outcome was hospitalization rates, while secondary outcomes were cost and in-hospital mortality. Overall, there were 443,222,223 hospitalizations during the study period, of which 2,419,722 were due to complications of systemic therapy. The average annual percentage change of these hospitalizations was 8.1%, compared to − 0.5% for general hospitalizations. The three most common causes for hospitalization were anemia (12.8%), neutropenia (10.8%), and sepsis (7.8%). Hospitalization rates had the highest relative increases for sepsis (1.9-fold) and acute kidney injury (1.6-fold), and the highest relative decrease for dehydration (0.21-fold) and fever of unknown origin (0.35-fold). Complications with the highest total charges were anemia ($4.6 billion), neutropenia ($3.0 billion), and sepsis ($2.5 billion). The leading causes of in-hospital mortality associated with systemic therapy were sepsis (15.8%), pneumonia (7.6%), and acute kidney injury (7.0%). Promoting initiatives such as rule OP-35, improving access to and providing coordinated care, developing systems leading to early identification and management of symptoms, and expanding urgent care access, can decrease these hospitalizations and the burden they carry on the healthcare system.Anshul SaxenaMuni RubensVenkataraghavan RamamoorthyRaees TonseEmir VeledarPeter McGranaghanSubrina SundilMichael D. ChuongMatthew D. HallYazmin OdiaMinesh P. MehtaRupesh KotechaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anshul Saxena Muni Rubens Venkataraghavan Ramamoorthy Raees Tonse Emir Veledar Peter McGranaghan Subrina Sundil Michael D. Chuong Matthew D. Hall Yazmin Odia Minesh P. Mehta Rupesh Kotecha Hospitalization rates for complications due to systemic therapy in the United States
description	Abstract The aim of this study was to estimate the trends and burdens associated with systemic therapy-related hospitalizations, using nationally representative data. National Inpatient Sample data from 2005 to 2016 was used to identify systemic therapy-related complications using ICD-9 and ICD-10 external causes-of-injury codes. The primary outcome was hospitalization rates, while secondary outcomes were cost and in-hospital mortality. Overall, there were 443,222,223 hospitalizations during the study period, of which 2,419,722 were due to complications of systemic therapy. The average annual percentage change of these hospitalizations was 8.1%, compared to − 0.5% for general hospitalizations. The three most common causes for hospitalization were anemia (12.8%), neutropenia (10.8%), and sepsis (7.8%). Hospitalization rates had the highest relative increases for sepsis (1.9-fold) and acute kidney injury (1.6-fold), and the highest relative decrease for dehydration (0.21-fold) and fever of unknown origin (0.35-fold). Complications with the highest total charges were anemia ($4.6 billion), neutropenia ($3.0 billion), and sepsis ($2.5 billion). The leading causes of in-hospital mortality associated with systemic therapy were sepsis (15.8%), pneumonia (7.6%), and acute kidney injury (7.0%). Promoting initiatives such as rule OP-35, improving access to and providing coordinated care, developing systems leading to early identification and management of symptoms, and expanding urgent care access, can decrease these hospitalizations and the burden they carry on the healthcare system.
format	article
author	Anshul Saxena Muni Rubens Venkataraghavan Ramamoorthy Raees Tonse Emir Veledar Peter McGranaghan Subrina Sundil Michael D. Chuong Matthew D. Hall Yazmin Odia Minesh P. Mehta Rupesh Kotecha
author_facet	Anshul Saxena Muni Rubens Venkataraghavan Ramamoorthy Raees Tonse Emir Veledar Peter McGranaghan Subrina Sundil Michael D. Chuong Matthew D. Hall Yazmin Odia Minesh P. Mehta Rupesh Kotecha
author_sort	Anshul Saxena
title	Hospitalization rates for complications due to systemic therapy in the United States
title_short	Hospitalization rates for complications due to systemic therapy in the United States
title_full	Hospitalization rates for complications due to systemic therapy in the United States
title_fullStr	Hospitalization rates for complications due to systemic therapy in the United States
title_full_unstemmed	Hospitalization rates for complications due to systemic therapy in the United States
title_sort	hospitalization rates for complications due to systemic therapy in the united states
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/afd9010f1ae240c388ec4e1b88344d0c
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Hospitalization rates for complications due to systemic therapy in the United States

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