How similar are the mice to men? Between-species comparison of left ventricular mechanics using strain imaging.

<h4>Background</h4>While mammalian heart size maintains constant proportion to whole body size, scaling of left ventricular (LV) function parameters shows a more complex scaling pattern. We used 2-D speckle tracking strain imaging to determine whether LV myocardial strains and strain rat...

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Autores principales:	Kenya Kusunose, Marc S Penn, Youhua Zhang, Yuanna Cheng, James D Thomas, Thomas H Marwick, Zoran B Popović
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/afdb9eaa9ba64393abbbf7bbe8e887cb
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spelling	oai:doaj.org-article:afdb9eaa9ba64393abbbf7bbe8e887cb2021-11-18T07:13:43ZHow similar are the mice to men? Between-species comparison of left ventricular mechanics using strain imaging.1932-620310.1371/journal.pone.0040061https://doaj.org/article/afdb9eaa9ba64393abbbf7bbe8e887cb2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22768220/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>While mammalian heart size maintains constant proportion to whole body size, scaling of left ventricular (LV) function parameters shows a more complex scaling pattern. We used 2-D speckle tracking strain imaging to determine whether LV myocardial strains and strain rates scale to heart size.<h4>Methods</h4>We studied 18 mice, 15 rats, 6 rabbits, 12 dogs and 20 human volunteers by 2-D echocardiography. Relationship between longitudinal or circumferential strains/strain rates (S(Long)/SR(Long), S(Circ)/SR(Circ)), and LV end-diastolic volume (EDV) or mass were assessed by the allometric (power-law) equation Y = kM(β).<h4>Results</h4>Mean LV mass in individual species varied from 0.038 to 134 g, LV EDV varied from 0.015 to 102 ml, while RR interval varied from 81 to 1090 ms. While S(Long) increased with increasing LV EDV or mass (β values 0.047±0.006 and 0.051±0.005, p<0.0001 vs. 0 for both) S(Circ) was unchanged (p = NS for both LV EDV or mass). Systolic and diastolic SR(Long) and SR(Circ) showed inverse correlations to LV EDV or mass (p<0.0001 vs. 0 for all comparisons). The ratio between S(Long) and S(Circ) increased with increasing values of LV EDV or mass (β values 0.039±0.010 and 0.040±0.011, p>0.0003 for both).<h4>Conclusions</h4>While S(Circ) is unchanged, S(Long) increases with increasing heart size, indicating that large mammals rely more on long axis contribution to systolic function. SR(Long) and SR(Circ), both diastolic and systolic, show an expected decrease with increasing heart size.Kenya KusunoseMarc S PennYouhua ZhangYuanna ChengJames D ThomasThomas H MarwickZoran B PopovićPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e40061 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kenya Kusunose Marc S Penn Youhua Zhang Yuanna Cheng James D Thomas Thomas H Marwick Zoran B Popović How similar are the mice to men? Between-species comparison of left ventricular mechanics using strain imaging.
description	<h4>Background</h4>While mammalian heart size maintains constant proportion to whole body size, scaling of left ventricular (LV) function parameters shows a more complex scaling pattern. We used 2-D speckle tracking strain imaging to determine whether LV myocardial strains and strain rates scale to heart size.<h4>Methods</h4>We studied 18 mice, 15 rats, 6 rabbits, 12 dogs and 20 human volunteers by 2-D echocardiography. Relationship between longitudinal or circumferential strains/strain rates (S(Long)/SR(Long), S(Circ)/SR(Circ)), and LV end-diastolic volume (EDV) or mass were assessed by the allometric (power-law) equation Y = kM(β).<h4>Results</h4>Mean LV mass in individual species varied from 0.038 to 134 g, LV EDV varied from 0.015 to 102 ml, while RR interval varied from 81 to 1090 ms. While S(Long) increased with increasing LV EDV or mass (β values 0.047±0.006 and 0.051±0.005, p<0.0001 vs. 0 for both) S(Circ) was unchanged (p = NS for both LV EDV or mass). Systolic and diastolic SR(Long) and SR(Circ) showed inverse correlations to LV EDV or mass (p<0.0001 vs. 0 for all comparisons). The ratio between S(Long) and S(Circ) increased with increasing values of LV EDV or mass (β values 0.039±0.010 and 0.040±0.011, p>0.0003 for both).<h4>Conclusions</h4>While S(Circ) is unchanged, S(Long) increases with increasing heart size, indicating that large mammals rely more on long axis contribution to systolic function. SR(Long) and SR(Circ), both diastolic and systolic, show an expected decrease with increasing heart size.
format	article
author	Kenya Kusunose Marc S Penn Youhua Zhang Yuanna Cheng James D Thomas Thomas H Marwick Zoran B Popović
author_facet	Kenya Kusunose Marc S Penn Youhua Zhang Yuanna Cheng James D Thomas Thomas H Marwick Zoran B Popović
author_sort	Kenya Kusunose
title	How similar are the mice to men? Between-species comparison of left ventricular mechanics using strain imaging.
title_short	How similar are the mice to men? Between-species comparison of left ventricular mechanics using strain imaging.
title_full	How similar are the mice to men? Between-species comparison of left ventricular mechanics using strain imaging.
title_fullStr	How similar are the mice to men? Between-species comparison of left ventricular mechanics using strain imaging.
title_full_unstemmed	How similar are the mice to men? Between-species comparison of left ventricular mechanics using strain imaging.
title_sort	how similar are the mice to men? between-species comparison of left ventricular mechanics using strain imaging.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/afdb9eaa9ba64393abbbf7bbe8e887cb
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How similar are the mice to men? Between-species comparison of left ventricular mechanics using strain imaging.

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