Impact of antibiotic usage on extended-spectrum β-lactamase producing Escherichia coli prevalence

Abstract An increase in antibiotic usage is considered to contribute to the emergence of antimicrobial resistance. Although experts are counting on the antimicrobial stewardship programs to reduce antibiotic usage, their effect remains uncertain. In this study, we aimed to evaluate the impact of ant...

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Autores principales:	Jeong Yeon Kim, Yunjin Yum, Hyung Joon Joo, Hyonggin An, Young Kyung Yoon, Jong Hun Kim, Jang Wook Sohn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/afdc240f7be94337a540e374f149fbe5
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spelling	oai:doaj.org-article:afdc240f7be94337a540e374f149fbe52021-12-02T18:02:49ZImpact of antibiotic usage on extended-spectrum β-lactamase producing Escherichia coli prevalence10.1038/s41598-021-91332-x2045-2322https://doaj.org/article/afdc240f7be94337a540e374f149fbe52021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91332-xhttps://doaj.org/toc/2045-2322Abstract An increase in antibiotic usage is considered to contribute to the emergence of antimicrobial resistance. Although experts are counting on the antimicrobial stewardship programs to reduce antibiotic usage, their effect remains uncertain. In this study, we aimed to evaluate the impact of antibiotic usage and forecast the prevalence of hospital-acquired extended spectrum β-lactamase (ESBL)—producing Escherichia coli (E. coli) using time-series analysis. Antimicrobial culture information of E. coli was obtained using a text processing technique that helped extract free-text electronic health records from standardized data. The antimicrobial use density (AUD) of antibiotics of interest was used to estimate the quarterly antibiotic usage. Transfer function model was applied to forecast relationship between antibiotic usage and ESBL-producing E. coli. Of the 1938 hospital-acquired isolates, 831 isolates (42.9%) were ESBL-producing E. coli. Both the proportion of ESBL-producing E. coli and AUD increased over time. The transfer model predicted that ciprofloxacin AUD is related to the proportion of ESBL-producing E. coli two quarters later. In conclusion, excessive use of antibiotics was shown to affect the prevalence of resistant organisms in the future. Therefore, the control of antibiotics with antimicrobial stewardship programs should be considered to restrict antimicrobial resistance.Jeong Yeon KimYunjin YumHyung Joon JooHyonggin AnYoung Kyung YoonJong Hun KimJang Wook SohnNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeong Yeon Kim Yunjin Yum Hyung Joon Joo Hyonggin An Young Kyung Yoon Jong Hun Kim Jang Wook Sohn Impact of antibiotic usage on extended-spectrum β-lactamase producing Escherichia coli prevalence
description	Abstract An increase in antibiotic usage is considered to contribute to the emergence of antimicrobial resistance. Although experts are counting on the antimicrobial stewardship programs to reduce antibiotic usage, their effect remains uncertain. In this study, we aimed to evaluate the impact of antibiotic usage and forecast the prevalence of hospital-acquired extended spectrum β-lactamase (ESBL)—producing Escherichia coli (E. coli) using time-series analysis. Antimicrobial culture information of E. coli was obtained using a text processing technique that helped extract free-text electronic health records from standardized data. The antimicrobial use density (AUD) of antibiotics of interest was used to estimate the quarterly antibiotic usage. Transfer function model was applied to forecast relationship between antibiotic usage and ESBL-producing E. coli. Of the 1938 hospital-acquired isolates, 831 isolates (42.9%) were ESBL-producing E. coli. Both the proportion of ESBL-producing E. coli and AUD increased over time. The transfer model predicted that ciprofloxacin AUD is related to the proportion of ESBL-producing E. coli two quarters later. In conclusion, excessive use of antibiotics was shown to affect the prevalence of resistant organisms in the future. Therefore, the control of antibiotics with antimicrobial stewardship programs should be considered to restrict antimicrobial resistance.
format	article
author	Jeong Yeon Kim Yunjin Yum Hyung Joon Joo Hyonggin An Young Kyung Yoon Jong Hun Kim Jang Wook Sohn
author_facet	Jeong Yeon Kim Yunjin Yum Hyung Joon Joo Hyonggin An Young Kyung Yoon Jong Hun Kim Jang Wook Sohn
author_sort	Jeong Yeon Kim
title	Impact of antibiotic usage on extended-spectrum β-lactamase producing Escherichia coli prevalence
title_short	Impact of antibiotic usage on extended-spectrum β-lactamase producing Escherichia coli prevalence
title_full	Impact of antibiotic usage on extended-spectrum β-lactamase producing Escherichia coli prevalence
title_fullStr	Impact of antibiotic usage on extended-spectrum β-lactamase producing Escherichia coli prevalence
title_full_unstemmed	Impact of antibiotic usage on extended-spectrum β-lactamase producing Escherichia coli prevalence
title_sort	impact of antibiotic usage on extended-spectrum β-lactamase producing escherichia coli prevalence
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/afdc240f7be94337a540e374f149fbe5
work_keys_str_mv	AT jeongyeonkim impactofantibioticusageonextendedspectrumblactamaseproducingescherichiacoliprevalence AT yunjinyum impactofantibioticusageonextendedspectrumblactamaseproducingescherichiacoliprevalence AT hyungjoonjoo impactofantibioticusageonextendedspectrumblactamaseproducingescherichiacoliprevalence AT hyongginan impactofantibioticusageonextendedspectrumblactamaseproducingescherichiacoliprevalence AT youngkyungyoon impactofantibioticusageonextendedspectrumblactamaseproducingescherichiacoliprevalence AT jonghunkim impactofantibioticusageonextendedspectrumblactamaseproducingescherichiacoliprevalence AT jangwooksohn impactofantibioticusageonextendedspectrumblactamaseproducingescherichiacoliprevalence
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Impact of antibiotic usage on extended-spectrum β-lactamase producing Escherichia coli prevalence

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