Evolving concepts in the selection of immunosuppression regimen for liver transplant recipients

Jayme E Locke, Andrew L SingerJohns Hopkins Medical Institutions, Department of Surgery, Division of Transplantation, Baltimore, MD, USAAbstract: The introduction of calcineurin inhibitor (CNI) based immunosuppression has revolutionized the field of liver transplantation by dramatically reducing the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Locke JE, Singer AL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/afdf084cb4824fdd97e1c08fb96a2c76
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:afdf084cb4824fdd97e1c08fb96a2c76
record_format	dspace
spelling	oai:doaj.org-article:afdf084cb4824fdd97e1c08fb96a2c762021-12-02T05:37:37ZEvolving concepts in the selection of immunosuppression regimen for liver transplant recipients1179-1535https://doaj.org/article/afdf084cb4824fdd97e1c08fb96a2c762011-05-01T00:00:00Zhttp://www.dovepress.com/evolving-concepts-in-the-selection-of-immunosuppression-regimen-for-li-a7443https://doaj.org/toc/1179-1535Jayme E Locke, Andrew L SingerJohns Hopkins Medical Institutions, Department of Surgery, Division of Transplantation, Baltimore, MD, USAAbstract: The introduction of calcineurin inhibitor (CNI) based immunosuppression has revolutionized the field of liver transplantation by dramatically reducing the incidence of acute cellular rejection and prolonging patient and allograft survival. However, the introduction of CNIs has also come at the price of increased patient morbidity, particularly with regard to the well-known nephrotoxic effects of the medications. In an effort to minimize the adverse effects, immunosuppression regimen have evolved to include the use of various induction agents and purine synthesis inhibitors to limit the dose of CNI necessary to achieve low acute cellular rejection rates. Careful assessments of risks and benefits are needed as these newer agents have their own side effect profiles. In addition, the impact of newer immunosuppression regimen on hepatitis C (HCV) recurrence has not been completely elucidated. This review will provide an overview of the most common immunosuppression regimen used in liver transplantation and discuss their impact on acute cellular rejection, patient and allograft survival, and HCV recurrence.Keywords: liver transplantation, immunosuppression, acute cellular rejection, patient and graft survival, hepatitis C recurrenceLocke JESinger ALDove Medical PressarticleDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol 2011, Iss default, Pp 53-62 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Locke JE Singer AL Evolving concepts in the selection of immunosuppression regimen for liver transplant recipients
description	Jayme E Locke, Andrew L SingerJohns Hopkins Medical Institutions, Department of Surgery, Division of Transplantation, Baltimore, MD, USAAbstract: The introduction of calcineurin inhibitor (CNI) based immunosuppression has revolutionized the field of liver transplantation by dramatically reducing the incidence of acute cellular rejection and prolonging patient and allograft survival. However, the introduction of CNIs has also come at the price of increased patient morbidity, particularly with regard to the well-known nephrotoxic effects of the medications. In an effort to minimize the adverse effects, immunosuppression regimen have evolved to include the use of various induction agents and purine synthesis inhibitors to limit the dose of CNI necessary to achieve low acute cellular rejection rates. Careful assessments of risks and benefits are needed as these newer agents have their own side effect profiles. In addition, the impact of newer immunosuppression regimen on hepatitis C (HCV) recurrence has not been completely elucidated. This review will provide an overview of the most common immunosuppression regimen used in liver transplantation and discuss their impact on acute cellular rejection, patient and allograft survival, and HCV recurrence.Keywords: liver transplantation, immunosuppression, acute cellular rejection, patient and graft survival, hepatitis C recurrence
format	article
author	Locke JE Singer AL
author_facet	Locke JE Singer AL
author_sort	Locke JE
title	Evolving concepts in the selection of immunosuppression regimen for liver transplant recipients
title_short	Evolving concepts in the selection of immunosuppression regimen for liver transplant recipients
title_full	Evolving concepts in the selection of immunosuppression regimen for liver transplant recipients
title_fullStr	Evolving concepts in the selection of immunosuppression regimen for liver transplant recipients
title_full_unstemmed	Evolving concepts in the selection of immunosuppression regimen for liver transplant recipients
title_sort	evolving concepts in the selection of immunosuppression regimen for liver transplant recipients
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/afdf084cb4824fdd97e1c08fb96a2c76
work_keys_str_mv	AT lockeje evolvingconceptsintheselectionofimmunosuppressionregimenforlivertransplantrecipients AT singeral evolvingconceptsintheselectionofimmunosuppressionregimenforlivertransplantrecipients
_version_	1718400315649163264

Evolving concepts in the selection of immunosuppression regimen for liver transplant recipients

Ejemplares similares