Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women
More than 10% of women suffer from endometriosis (EMT) during their reproductive years. EMT can cause pain and infertility and requires further study from multiple perspectives. Previous reports have indicated that an increase inapolipoprotein E (ApoE) may be associated with a lower number of retrie...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:afdf94f6d5ee496ba6a4b7d8197006ac2021-11-17T11:08:09ZIncreased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women1664-239210.3389/fendo.2021.779183https://doaj.org/article/afdf94f6d5ee496ba6a4b7d8197006ac2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.779183/fullhttps://doaj.org/toc/1664-2392More than 10% of women suffer from endometriosis (EMT) during their reproductive years. EMT can cause pain and infertility and requires further study from multiple perspectives. Previous reports have indicated that an increase inapolipoprotein E (ApoE) may be associated with a lower number of retrieved mature oocytes in older women, and an association between ApoE and spontaneous pregnancy loss may exist in patients with EMT. The purpose of this study was to investigate the existence of an increase in ApoE in follicular fluid (FF) and the possible relationship between ApoE and EMT in Chinese women. In the current study, 217 Chinese women (111 control subjects and 106 EMT patients) were included. The ApoE genotypes were identified by Sanger sequencing. We found that ApoE expression in FF was higher in patients with EMT than in the control group. In addition, a significant difference in ApoE4 carriers (ϵ3/ϵ4, ϵ4/ϵ4) was found between the control subjects and the patients with EMT. Furthermore, a nonparametric test revealed significant differences in the numbers of blastocysts and high-quality blastocysts, but not the hormone levels of FSH, LH, and E2, between the two groups. We also established a multifactor (BMI, high-quality blastocysts, and ϵ4) prediction model with good sensitivity for identifying patients who may suffer from EMT. Our results demonstrate that ApoE expression in FF is increased in EMT, the ApoE-ϵ4 allele is significantly linked to EMT, and a combined analysis of three factors (BMI, high-quality blastocysts, and ϵ4) could be used as a predictor of EMT.Ya-Jing LiuYa-Jing LiuYa-Jing LiuYa-Jing LiuYa-Jing LiuFen XingFen XingFen XingFen XingFen XingKai ZongMeng-Yao WangMeng-Yao WangMeng-Yao WangMeng-Yao WangMeng-Yao WangDong-Mei JiDong-Mei JiDong-Mei JiDong-Mei JiDong-Mei JiYu-Hang ZhaoYun-He XiaAn WangLing-Ge ShiLing-Ge ShiLing-Ge ShiLing-Ge ShiLing-Ge ShiSi-Min DingSi-Min DingSi-Min DingSi-Min DingSi-Min DingZhao-Lian WeiZhao-Lian WeiZhao-Lian WeiZhao-Lian WeiZhao-Lian WeiJin-Ping QiaoXin DuYun-Xia CaoYun-Xia CaoYun-Xia CaoYun-Xia CaoYun-Xia CaoFrontiers Media S.A.articleapolipoprotein Eendometriosisfollicular fluidgenotypemultifactor prediction modelDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
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| topic |
apolipoprotein E endometriosis follicular fluid genotype multifactor prediction model Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
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apolipoprotein E endometriosis follicular fluid genotype multifactor prediction model Diseases of the endocrine glands. Clinical endocrinology RC648-665 Ya-Jing Liu Ya-Jing Liu Ya-Jing Liu Ya-Jing Liu Ya-Jing Liu Fen Xing Fen Xing Fen Xing Fen Xing Fen Xing Kai Zong Meng-Yao Wang Meng-Yao Wang Meng-Yao Wang Meng-Yao Wang Meng-Yao Wang Dong-Mei Ji Dong-Mei Ji Dong-Mei Ji Dong-Mei Ji Dong-Mei Ji Yu-Hang Zhao Yun-He Xia An Wang Ling-Ge Shi Ling-Ge Shi Ling-Ge Shi Ling-Ge Shi Ling-Ge Shi Si-Min Ding Si-Min Ding Si-Min Ding Si-Min Ding Si-Min Ding Zhao-Lian Wei Zhao-Lian Wei Zhao-Lian Wei Zhao-Lian Wei Zhao-Lian Wei Jin-Ping Qiao Xin Du Yun-Xia Cao Yun-Xia Cao Yun-Xia Cao Yun-Xia Cao Yun-Xia Cao Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women |
| description |
More than 10% of women suffer from endometriosis (EMT) during their reproductive years. EMT can cause pain and infertility and requires further study from multiple perspectives. Previous reports have indicated that an increase inapolipoprotein E (ApoE) may be associated with a lower number of retrieved mature oocytes in older women, and an association between ApoE and spontaneous pregnancy loss may exist in patients with EMT. The purpose of this study was to investigate the existence of an increase in ApoE in follicular fluid (FF) and the possible relationship between ApoE and EMT in Chinese women. In the current study, 217 Chinese women (111 control subjects and 106 EMT patients) were included. The ApoE genotypes were identified by Sanger sequencing. We found that ApoE expression in FF was higher in patients with EMT than in the control group. In addition, a significant difference in ApoE4 carriers (ϵ3/ϵ4, ϵ4/ϵ4) was found between the control subjects and the patients with EMT. Furthermore, a nonparametric test revealed significant differences in the numbers of blastocysts and high-quality blastocysts, but not the hormone levels of FSH, LH, and E2, between the two groups. We also established a multifactor (BMI, high-quality blastocysts, and ϵ4) prediction model with good sensitivity for identifying patients who may suffer from EMT. Our results demonstrate that ApoE expression in FF is increased in EMT, the ApoE-ϵ4 allele is significantly linked to EMT, and a combined analysis of three factors (BMI, high-quality blastocysts, and ϵ4) could be used as a predictor of EMT. |
| format |
article |
| author |
Ya-Jing Liu Ya-Jing Liu Ya-Jing Liu Ya-Jing Liu Ya-Jing Liu Fen Xing Fen Xing Fen Xing Fen Xing Fen Xing Kai Zong Meng-Yao Wang Meng-Yao Wang Meng-Yao Wang Meng-Yao Wang Meng-Yao Wang Dong-Mei Ji Dong-Mei Ji Dong-Mei Ji Dong-Mei Ji Dong-Mei Ji Yu-Hang Zhao Yun-He Xia An Wang Ling-Ge Shi Ling-Ge Shi Ling-Ge Shi Ling-Ge Shi Ling-Ge Shi Si-Min Ding Si-Min Ding Si-Min Ding Si-Min Ding Si-Min Ding Zhao-Lian Wei Zhao-Lian Wei Zhao-Lian Wei Zhao-Lian Wei Zhao-Lian Wei Jin-Ping Qiao Xin Du Yun-Xia Cao Yun-Xia Cao Yun-Xia Cao Yun-Xia Cao Yun-Xia Cao |
| author_facet |
Ya-Jing Liu Ya-Jing Liu Ya-Jing Liu Ya-Jing Liu Ya-Jing Liu Fen Xing Fen Xing Fen Xing Fen Xing Fen Xing Kai Zong Meng-Yao Wang Meng-Yao Wang Meng-Yao Wang Meng-Yao Wang Meng-Yao Wang Dong-Mei Ji Dong-Mei Ji Dong-Mei Ji Dong-Mei Ji Dong-Mei Ji Yu-Hang Zhao Yun-He Xia An Wang Ling-Ge Shi Ling-Ge Shi Ling-Ge Shi Ling-Ge Shi Ling-Ge Shi Si-Min Ding Si-Min Ding Si-Min Ding Si-Min Ding Si-Min Ding Zhao-Lian Wei Zhao-Lian Wei Zhao-Lian Wei Zhao-Lian Wei Zhao-Lian Wei Jin-Ping Qiao Xin Du Yun-Xia Cao Yun-Xia Cao Yun-Xia Cao Yun-Xia Cao Yun-Xia Cao |
| author_sort |
Ya-Jing Liu |
| title |
Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women |
| title_short |
Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women |
| title_full |
Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women |
| title_fullStr |
Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women |
| title_full_unstemmed |
Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women |
| title_sort |
increased apoe expression in follicular fluid and the apoe genotype are associated with endometriosis in chinese women |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/afdf94f6d5ee496ba6a4b7d8197006ac |
| work_keys_str_mv |
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