Genome Sequences Reveal Cryptic Speciation in the Human Pathogen <italic toggle="yes">Histoplasma capsulatum</italic>

ABSTRACT Histoplasma capsulatum is a pathogenic fungus that causes life-threatening lung infections. About 500,000 people are exposed to H. capsulatum each year in the United States, and over 60% of the U.S. population has been exposed to the fungus at some point in their life. We performed genome-w...

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Autores principales:	Victoria E. Sepúlveda, Roberto Márquez, David A. Turissini, William E. Goldman, Daniel R. Matute
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	cryptic speciation Histoplasma phylogenetic species concept genomic alignment taxonomy Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/afe36cd2a33d44298b0c23a6f64b15a8
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spelling	oai:doaj.org-article:afe36cd2a33d44298b0c23a6f64b15a82021-11-15T15:51:56ZGenome Sequences Reveal Cryptic Speciation in the Human Pathogen <italic toggle="yes">Histoplasma capsulatum</italic>10.1128/mBio.01339-172150-7511https://doaj.org/article/afe36cd2a33d44298b0c23a6f64b15a82017-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01339-17https://doaj.org/toc/2150-7511ABSTRACT Histoplasma capsulatum is a pathogenic fungus that causes life-threatening lung infections. About 500,000 people are exposed to H. capsulatum each year in the United States, and over 60% of the U.S. population has been exposed to the fungus at some point in their life. We performed genome-wide population genetics and phylogenetic analyses with 30 Histoplasma isolates representing four recognized areas where histoplasmosis is endemic and show that the Histoplasma genus is composed of at least four species that are genetically isolated and rarely interbreed. Therefore, we propose a taxonomic rearrangement of the genus. IMPORTANCE The evolutionary processes that give rise to new pathogen lineages are critical to our understanding of how they adapt to new environments and how frequently they exchange genes with each other. The fungal pathogen Histoplasma capsulatum provides opportunities to precisely test hypotheses about the origin of new genetic variation. We find that H. capsulatum is composed of at least four different cryptic species that differ genetically and also in virulence. These results have implications for the epidemiology of histoplasmosis because not all Histoplasma species are equivalent in their geographic range and ability to cause disease.Victoria E. SepúlvedaRoberto MárquezDavid A. TurissiniWilliam E. GoldmanDaniel R. MatuteAmerican Society for Microbiologyarticlecryptic speciationHistoplasmaphylogenetic species conceptgenomic alignmenttaxonomyMicrobiologyQR1-502ENmBio, Vol 8, Iss 6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	cryptic speciation Histoplasma phylogenetic species concept genomic alignment taxonomy Microbiology QR1-502
spellingShingle	cryptic speciation Histoplasma phylogenetic species concept genomic alignment taxonomy Microbiology QR1-502 Victoria E. Sepúlveda Roberto Márquez David A. Turissini William E. Goldman Daniel R. Matute Genome Sequences Reveal Cryptic Speciation in the Human Pathogen <italic toggle="yes">Histoplasma capsulatum</italic>
description	ABSTRACT Histoplasma capsulatum is a pathogenic fungus that causes life-threatening lung infections. About 500,000 people are exposed to H. capsulatum each year in the United States, and over 60% of the U.S. population has been exposed to the fungus at some point in their life. We performed genome-wide population genetics and phylogenetic analyses with 30 Histoplasma isolates representing four recognized areas where histoplasmosis is endemic and show that the Histoplasma genus is composed of at least four species that are genetically isolated and rarely interbreed. Therefore, we propose a taxonomic rearrangement of the genus. IMPORTANCE The evolutionary processes that give rise to new pathogen lineages are critical to our understanding of how they adapt to new environments and how frequently they exchange genes with each other. The fungal pathogen Histoplasma capsulatum provides opportunities to precisely test hypotheses about the origin of new genetic variation. We find that H. capsulatum is composed of at least four different cryptic species that differ genetically and also in virulence. These results have implications for the epidemiology of histoplasmosis because not all Histoplasma species are equivalent in their geographic range and ability to cause disease.
format	article
author	Victoria E. Sepúlveda Roberto Márquez David A. Turissini William E. Goldman Daniel R. Matute
author_facet	Victoria E. Sepúlveda Roberto Márquez David A. Turissini William E. Goldman Daniel R. Matute
author_sort	Victoria E. Sepúlveda
title	Genome Sequences Reveal Cryptic Speciation in the Human Pathogen <italic toggle="yes">Histoplasma capsulatum</italic>
title_short	Genome Sequences Reveal Cryptic Speciation in the Human Pathogen <italic toggle="yes">Histoplasma capsulatum</italic>
title_full	Genome Sequences Reveal Cryptic Speciation in the Human Pathogen <italic toggle="yes">Histoplasma capsulatum</italic>
title_fullStr	Genome Sequences Reveal Cryptic Speciation in the Human Pathogen <italic toggle="yes">Histoplasma capsulatum</italic>
title_full_unstemmed	Genome Sequences Reveal Cryptic Speciation in the Human Pathogen <italic toggle="yes">Histoplasma capsulatum</italic>
title_sort	genome sequences reveal cryptic speciation in the human pathogen <italic toggle="yes">histoplasma capsulatum</italic>
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/afe36cd2a33d44298b0c23a6f64b15a8
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Genome Sequences Reveal Cryptic Speciation in the Human Pathogen <italic toggle="yes">Histoplasma capsulatum</italic>

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