Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through

Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through

The miR-141/200 familly of micro RNAs control oxidative stress and impact on ovarian tumorigenesis. Here the authors show that the transcription of miR-200c/141 is regulated through transcriptional read-through of the upstream gene PTPN6, and DNA looping linking the PTPN6 and miR-200c/141 promoters.

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Autores principales: Luciana Batista, Brigitte Bourachot, Bogdan Mateescu, Fabien Reyal, Fatima Mechta-Grigoriou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/afe445d2f89f454598efa763db669fc7
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spelling oai:doaj.org-article:afe445d2f89f454598efa763db669fc72021-12-02T17:32:37ZRegulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through10.1038/ncomms99592041-1723https://doaj.org/article/afe445d2f89f454598efa763db669fc72016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms9959https://doaj.org/toc/2041-1723The miR-141/200 familly of micro RNAs control oxidative stress and impact on ovarian tumorigenesis. Here the authors show that the transcription of miR-200c/141 is regulated through transcriptional read-through of the upstream gene PTPN6, and DNA looping linking the PTPN6 and miR-200c/141 promoters.Luciana BatistaBrigitte BourachotBogdan MateescuFabien ReyalFatima Mechta-GrigoriouNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Luciana Batista
Brigitte Bourachot
Bogdan Mateescu
Fabien Reyal
Fatima Mechta-Grigoriou
Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through
description The miR-141/200 familly of micro RNAs control oxidative stress and impact on ovarian tumorigenesis. Here the authors show that the transcription of miR-200c/141 is regulated through transcriptional read-through of the upstream gene PTPN6, and DNA looping linking the PTPN6 and miR-200c/141 promoters.
format article
author Luciana Batista
Brigitte Bourachot
Bogdan Mateescu
Fabien Reyal
Fatima Mechta-Grigoriou
author_facet Luciana Batista
Brigitte Bourachot
Bogdan Mateescu
Fabien Reyal
Fatima Mechta-Grigoriou
author_sort Luciana Batista
title Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through
title_short Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through
title_full Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through
title_fullStr Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through
title_full_unstemmed Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through
title_sort regulation of mir-200c/141 expression by intergenic dna-looping and transcriptional read-through
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/afe445d2f89f454598efa763db669fc7
work_keys_str_mv AT lucianabatista regulationofmir200c141expressionbyintergenicdnaloopingandtranscriptionalreadthrough
AT brigittebourachot regulationofmir200c141expressionbyintergenicdnaloopingandtranscriptionalreadthrough
AT bogdanmateescu regulationofmir200c141expressionbyintergenicdnaloopingandtranscriptionalreadthrough
AT fabienreyal regulationofmir200c141expressionbyintergenicdnaloopingandtranscriptionalreadthrough
AT fatimamechtagrigoriou regulationofmir200c141expressionbyintergenicdnaloopingandtranscriptionalreadthrough
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