Age at onset of obesity, transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism, adiponectin levels and the risk of type 2 diabetes in obese patients

Introduction Interaction between obesity and genetic factors involved in the regulatory pathways of glucose homeostasis may play a significant role in diabetes development in the obese. The aim of this study was to investigate the associations between the TCF7L2 rs7903146 polymorphism, adiponectin l...

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Autores principales:	Małgorzata Wrzosek, Ada Sawicka, Michał Wrzosek, Paweł Piątkiewicz, Marek Tałałaj, Grażyna Nowicka
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	obesity adiponectin type 2 diabetes tcf7l2 gene Medicine R
Acceso en línea:	https://doaj.org/article/afeb83d600e3482f816f54744ec72808
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spelling	oai:doaj.org-article:afeb83d600e3482f816f54744ec728082021-12-02T16:58:44ZAge at onset of obesity, transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism, adiponectin levels and the risk of type 2 diabetes in obese patients1734-19221896-915110.5114/aoms.2017.69638https://doaj.org/article/afeb83d600e3482f816f54744ec728082019-03-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Age-at-onset-of-obesity-transcription-factor-7-like-2-TCF7L2-rs7903146-polymorphism,68931,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Interaction between obesity and genetic factors involved in the regulatory pathways of glucose homeostasis may play a significant role in diabetes development in the obese. The aim of this study was to investigate the associations between the TCF7L2 rs7903146 polymorphism, adiponectin levels, age at onset of obesity and the occurrence of type 2 diabetes (T2D) in a sample of obese Polish adults. Material and methods A total of 474 unrelated obese subjects were included in this study. Real-time PCR was used to detect the TCF7L2 rs7903146 polymorphism. Serum level of adiponectin was determined by the ELISA method. Standard assays were used to measure total cholesterol, HDL cholesterol, triglycerides, glucose and HbA 1c concentrations. We used multiple logistic regression to identify factors associated with type 2 diabetes. Results We found that the T allele of rs7903146 was significantly associated with T2D risk (odds ratio of 1.59 for T allele, p = 0.005). This association persisted after adjusting for confounders in the recessive model (odds ratio of 3.54 for TT genotype, p = 0.011). Serum adiponectin levels were significantly lower in diabetic subjects than in nondiabetic individuals (3.6 vs. 5.6 µg/ml, p < 0.001). Participants who were obese at age ≥ 20 years had significantly higher odds of having T2D (OR = 4.94) than those with the onset of obesity before 20 years (p < 0.001). Conclusions Our study highlights the significance of the relationship between the TCF7L2 polymorphism, a person’s age at onset of obesity and the prevalence of T2D, and confirms lower adiponectin levels in obese diabetics in comparison to obese nondiabetics.Małgorzata WrzosekAda SawickaMichał WrzosekPaweł PiątkiewiczMarek TałałajGrażyna NowickaTermedia Publishing Housearticleobesityadiponectintype 2 diabetestcf7l2 geneMedicineRENArchives of Medical Science, Vol 15, Iss 2, Pp 321-329 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity adiponectin type 2 diabetes tcf7l2 gene Medicine R
spellingShingle	obesity adiponectin type 2 diabetes tcf7l2 gene Medicine R Małgorzata Wrzosek Ada Sawicka Michał Wrzosek Paweł Piątkiewicz Marek Tałałaj Grażyna Nowicka Age at onset of obesity, transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism, adiponectin levels and the risk of type 2 diabetes in obese patients
description	Introduction Interaction between obesity and genetic factors involved in the regulatory pathways of glucose homeostasis may play a significant role in diabetes development in the obese. The aim of this study was to investigate the associations between the TCF7L2 rs7903146 polymorphism, adiponectin levels, age at onset of obesity and the occurrence of type 2 diabetes (T2D) in a sample of obese Polish adults. Material and methods A total of 474 unrelated obese subjects were included in this study. Real-time PCR was used to detect the TCF7L2 rs7903146 polymorphism. Serum level of adiponectin was determined by the ELISA method. Standard assays were used to measure total cholesterol, HDL cholesterol, triglycerides, glucose and HbA 1c concentrations. We used multiple logistic regression to identify factors associated with type 2 diabetes. Results We found that the T allele of rs7903146 was significantly associated with T2D risk (odds ratio of 1.59 for T allele, p = 0.005). This association persisted after adjusting for confounders in the recessive model (odds ratio of 3.54 for TT genotype, p = 0.011). Serum adiponectin levels were significantly lower in diabetic subjects than in nondiabetic individuals (3.6 vs. 5.6 µg/ml, p < 0.001). Participants who were obese at age ≥ 20 years had significantly higher odds of having T2D (OR = 4.94) than those with the onset of obesity before 20 years (p < 0.001). Conclusions Our study highlights the significance of the relationship between the TCF7L2 polymorphism, a person’s age at onset of obesity and the prevalence of T2D, and confirms lower adiponectin levels in obese diabetics in comparison to obese nondiabetics.
format	article
author	Małgorzata Wrzosek Ada Sawicka Michał Wrzosek Paweł Piątkiewicz Marek Tałałaj Grażyna Nowicka
author_facet	Małgorzata Wrzosek Ada Sawicka Michał Wrzosek Paweł Piątkiewicz Marek Tałałaj Grażyna Nowicka
author_sort	Małgorzata Wrzosek
title	Age at onset of obesity, transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism, adiponectin levels and the risk of type 2 diabetes in obese patients
title_short	Age at onset of obesity, transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism, adiponectin levels and the risk of type 2 diabetes in obese patients
title_full	Age at onset of obesity, transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism, adiponectin levels and the risk of type 2 diabetes in obese patients
title_fullStr	Age at onset of obesity, transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism, adiponectin levels and the risk of type 2 diabetes in obese patients
title_full_unstemmed	Age at onset of obesity, transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism, adiponectin levels and the risk of type 2 diabetes in obese patients
title_sort	age at onset of obesity, transcription factor 7-like 2 (tcf7l2) rs7903146 polymorphism, adiponectin levels and the risk of type 2 diabetes in obese patients
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/afeb83d600e3482f816f54744ec72808
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Age at onset of obesity, transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism, adiponectin levels and the risk of type 2 diabetes in obese patients

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