Elucidating the aetiology of human Campylobacter coli infections.

There has been little research on the determinants of Campylobacter coli infection, despite its contributing up to 10% of human Campylobacter infections. A case-control and two case-case study methods explored the aetiology of C. coli over a one year period across Scotland. The case-control multivar...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Francois Roux, Emma Sproston, Ovidiu Rotariu, Marion Macrae, Samuel K Sheppard, Paul Bessell, Alison Smith-Palmer, John Cowden, Martin C J Maiden, Ken J Forbes, Norval J C Strachan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/afec46f023f84bb2be284a3b9ae05df7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:afec46f023f84bb2be284a3b9ae05df7
record_format	dspace
spelling	oai:doaj.org-article:afec46f023f84bb2be284a3b9ae05df72021-11-18T07:43:56ZElucidating the aetiology of human Campylobacter coli infections.1932-620310.1371/journal.pone.0064504https://doaj.org/article/afec46f023f84bb2be284a3b9ae05df72013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23734204/?tool=EBIhttps://doaj.org/toc/1932-6203There has been little research on the determinants of Campylobacter coli infection, despite its contributing up to 10% of human Campylobacter infections. A case-control and two case-case study methods explored the aetiology of C. coli over a one year period across Scotland. The case-control multivariate model found an increased risk of C. coli infection in people older than 19 years (O.R. = 3.352), and during the summer months (O.R. = 2.596), while residing in an urban area decreased the risk (O.R. = 0.546). The first case-case study compared C. coli and C. jejuni cases and also showed a higher risk of C. coli during the summer (O.R. = 1.313) and in people older than 19 years (O.R. = 0.791). Living in an urban area was associated with a reduced risk of infection (O.R. = 0.769). Multi-locus sequence typing (MLST) indicated that sheep and chicken C. coli sequence types (STs) were most frequently found in humans whilst those from cattle and pigs were rarer. MLST diversity was high in isolates from pigs and chicken, intermediate in human isolates, and low in ruminant isolates. The second case-case study used MLST data to ascribe putative sources of infection to the cases. The putative source for 40% of cases was chicken, with 60% acquired from other sources (ruminants 54% and pigs 6%). The case-case analysis also showed that female gender was a risk factor (O.R. = 1.940), which may be explained by females being more likely to prepare poultry in the home. These findings indicate differences between the aetiology of C. coli and C. jejuni infections: this should be taken into account by public health professionals when developing strategies to reduce the burden of human campylobacteriosis.Francois RouxEmma SprostonOvidiu RotariuMarion MacraeSamuel K SheppardPaul BessellAlison Smith-PalmerJohn CowdenMartin C J MaidenKen J ForbesNorval J C StrachanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e64504 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Francois Roux Emma Sproston Ovidiu Rotariu Marion Macrae Samuel K Sheppard Paul Bessell Alison Smith-Palmer John Cowden Martin C J Maiden Ken J Forbes Norval J C Strachan Elucidating the aetiology of human Campylobacter coli infections.
description	There has been little research on the determinants of Campylobacter coli infection, despite its contributing up to 10% of human Campylobacter infections. A case-control and two case-case study methods explored the aetiology of C. coli over a one year period across Scotland. The case-control multivariate model found an increased risk of C. coli infection in people older than 19 years (O.R. = 3.352), and during the summer months (O.R. = 2.596), while residing in an urban area decreased the risk (O.R. = 0.546). The first case-case study compared C. coli and C. jejuni cases and also showed a higher risk of C. coli during the summer (O.R. = 1.313) and in people older than 19 years (O.R. = 0.791). Living in an urban area was associated with a reduced risk of infection (O.R. = 0.769). Multi-locus sequence typing (MLST) indicated that sheep and chicken C. coli sequence types (STs) were most frequently found in humans whilst those from cattle and pigs were rarer. MLST diversity was high in isolates from pigs and chicken, intermediate in human isolates, and low in ruminant isolates. The second case-case study used MLST data to ascribe putative sources of infection to the cases. The putative source for 40% of cases was chicken, with 60% acquired from other sources (ruminants 54% and pigs 6%). The case-case analysis also showed that female gender was a risk factor (O.R. = 1.940), which may be explained by females being more likely to prepare poultry in the home. These findings indicate differences between the aetiology of C. coli and C. jejuni infections: this should be taken into account by public health professionals when developing strategies to reduce the burden of human campylobacteriosis.
format	article
author	Francois Roux Emma Sproston Ovidiu Rotariu Marion Macrae Samuel K Sheppard Paul Bessell Alison Smith-Palmer John Cowden Martin C J Maiden Ken J Forbes Norval J C Strachan
author_facet	Francois Roux Emma Sproston Ovidiu Rotariu Marion Macrae Samuel K Sheppard Paul Bessell Alison Smith-Palmer John Cowden Martin C J Maiden Ken J Forbes Norval J C Strachan
author_sort	Francois Roux
title	Elucidating the aetiology of human Campylobacter coli infections.
title_short	Elucidating the aetiology of human Campylobacter coli infections.
title_full	Elucidating the aetiology of human Campylobacter coli infections.
title_fullStr	Elucidating the aetiology of human Campylobacter coli infections.
title_full_unstemmed	Elucidating the aetiology of human Campylobacter coli infections.
title_sort	elucidating the aetiology of human campylobacter coli infections.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/afec46f023f84bb2be284a3b9ae05df7
work_keys_str_mv	AT francoisroux elucidatingtheaetiologyofhumancampylobactercoliinfections AT emmasproston elucidatingtheaetiologyofhumancampylobactercoliinfections AT ovidiurotariu elucidatingtheaetiologyofhumancampylobactercoliinfections AT marionmacrae elucidatingtheaetiologyofhumancampylobactercoliinfections AT samuelksheppard elucidatingtheaetiologyofhumancampylobactercoliinfections AT paulbessell elucidatingtheaetiologyofhumancampylobactercoliinfections AT alisonsmithpalmer elucidatingtheaetiologyofhumancampylobactercoliinfections AT johncowden elucidatingtheaetiologyofhumancampylobactercoliinfections AT martincjmaiden elucidatingtheaetiologyofhumancampylobactercoliinfections AT kenjforbes elucidatingtheaetiologyofhumancampylobactercoliinfections AT norvaljcstrachan elucidatingtheaetiologyofhumancampylobactercoliinfections
_version_	1718423056188178432

Elucidating the aetiology of human Campylobacter coli infections.

Ejemplares similares