Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling

Inflammation is known to affect cancer development, yet the mechanisms by which immune signaling drives transformation remain unclear. Here, the authors provide evidence that chronic TNF-α signaling promotes the enhancer binding and transcriptional interplay between mutant p53 and NFκB.

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Autores principales:	Homa Rahnamoun, Hanbin Lu, Sascha H. Duttke, Christopher Benner, Christopher K. Glass, Shannon M. Lauberth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/afeca2176ca641f4a733a0cf6b0463bc
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spelling	oai:doaj.org-article:afeca2176ca641f4a733a0cf6b0463bc2021-12-02T14:42:35ZMutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling10.1038/s41467-017-01117-y2041-1723https://doaj.org/article/afeca2176ca641f4a733a0cf6b0463bc2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01117-yhttps://doaj.org/toc/2041-1723Inflammation is known to affect cancer development, yet the mechanisms by which immune signaling drives transformation remain unclear. Here, the authors provide evidence that chronic TNF-α signaling promotes the enhancer binding and transcriptional interplay between mutant p53 and NFκB.Homa RahnamounHanbin LuSascha H. DuttkeChristopher BennerChristopher K. GlassShannon M. LauberthNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Homa Rahnamoun Hanbin Lu Sascha H. Duttke Christopher Benner Christopher K. Glass Shannon M. Lauberth Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling
description	Inflammation is known to affect cancer development, yet the mechanisms by which immune signaling drives transformation remain unclear. Here, the authors provide evidence that chronic TNF-α signaling promotes the enhancer binding and transcriptional interplay between mutant p53 and NFκB.
format	article
author	Homa Rahnamoun Hanbin Lu Sascha H. Duttke Christopher Benner Christopher K. Glass Shannon M. Lauberth
author_facet	Homa Rahnamoun Hanbin Lu Sascha H. Duttke Christopher Benner Christopher K. Glass Shannon M. Lauberth
author_sort	Homa Rahnamoun
title	Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling
title_short	Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling
title_full	Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling
title_fullStr	Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling
title_full_unstemmed	Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling
title_sort	mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/afeca2176ca641f4a733a0cf6b0463bc
work_keys_str_mv	AT homarahnamoun mutantp53shapestheenhancerlandscapeofcancercellsinresponsetochronicimmunesignaling AT hanbinlu mutantp53shapestheenhancerlandscapeofcancercellsinresponsetochronicimmunesignaling AT saschahduttke mutantp53shapestheenhancerlandscapeofcancercellsinresponsetochronicimmunesignaling AT christopherbenner mutantp53shapestheenhancerlandscapeofcancercellsinresponsetochronicimmunesignaling AT christopherkglass mutantp53shapestheenhancerlandscapeofcancercellsinresponsetochronicimmunesignaling AT shannonmlauberth mutantp53shapestheenhancerlandscapeofcancercellsinresponsetochronicimmunesignaling
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Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling

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