Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling

Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling

Inflammation is known to affect cancer development, yet the mechanisms by which immune signaling drives transformation remain unclear. Here, the authors provide evidence that chronic TNF-α signaling promotes the enhancer binding and transcriptional interplay between mutant p53 and NFκB.

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Autores principales: Homa Rahnamoun, Hanbin Lu, Sascha H. Duttke, Christopher Benner, Christopher K. Glass, Shannon M. Lauberth
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/afeca2176ca641f4a733a0cf6b0463bc
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