Pre-operative pyuria predicts tumor recurrence in patients undergoing transurethral resection of bladder tumor with post-operative instillation of BCG

BACKGROUND & OBJECTIVE: In Pakistan, urinary bladder cancer is one of the top ten malignancies. The most important concern after its treatment is tumor recurrence. Recent literature claimed that pre-operative pyuria in patients undergoing transurethral resection of bladder tumor was associated...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Syed Atif Hussain, Majed Saeed, Atta Ur Rehman Rana, Khizar Hayat Gondala, Ali Shandar Durrani, Muhammad Raheem Sajjad
Formato:	article
Lenguaje:	EN
Publicado:	University of Faisalabad 2021
Materias:	Transurethral Resection of Bladder Tumor Pyuria Tumor Recurrence Kisspeptin Spexin, Lipid Profile Obesity Medicine R
Acceso en línea:	https://doaj.org/article/afecbf9228a64731a889f05cc3a2c9de
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:afecbf9228a64731a889f05cc3a2c9de
record_format	dspace
spelling	oai:doaj.org-article:afecbf9228a64731a889f05cc3a2c9de2021-11-28T06:14:54ZPre-operative pyuria predicts tumor recurrence in patients undergoing transurethral resection of bladder tumor with post-operative instillation of BCG10.37723/jumdc.v12i4.5312221-78272310-5542https://doaj.org/article/afecbf9228a64731a889f05cc3a2c9de2021-11-01T00:00:00Zhttp://www.jumdc.com/index.php/jumdc/article/view/531https://doaj.org/toc/2221-7827https://doaj.org/toc/2310-5542 BACKGROUND & OBJECTIVE: In Pakistan, urinary bladder cancer is one of the top ten malignancies. The most important concern after its treatment is tumor recurrence. Recent literature claimed that pre-operative pyuria in patients undergoing transurethral resection of bladder tumor was associated with significantly higher frequency of recurrence. However, there was controversy in existing literature and no such local published material was available which necessitated the present study. To determine the frequency of pre-operative pyuria in patients undergoing transurethral resection of bladder tumor for non-muscle invasive bladder cancer (NMIBC) with post-operative instillation of Bacillus Calmette Guerin (BCG) and to compare the frequency of tumor recurrence in patients with and without pre-operative pyuria. METHODOLOGY: It was a comparative study. This study involved 280 patients of both genders aged between 20-80 years. Pre-operative pyuria was diagnosed if early morning midstream urine specimen showed ≥10 white blood cells/HPF. Outcome variable was frequency of recurrence after 12 weeks of treatment on check cystoscopy. RESULTS: The mean age of the patients was 57.1±8.5 years. There were 236 (84.3%) male and 44 (15.7%) female patients in the study. 155 (55.4%) patients were tobacco smoker. Pre-operative pyuria was diagnosed in 127 (45.4%) patients while tumor recurrence was observed in 183 (65.4%) patients. The frequency of tumor recurrence was significantly higher in patients with pre-operative pyuria (85.8% vs. 48.4%; p<0.001). CONCLUSION: Pre-operative pyuria was a frequent finding in patients with non-muscle invasive bladder tumor and was associated with higher frequency of tumor recurrence which warrants routine screening of such patients for pyuria and increased frequency of tumor recurrence. Syed Atif HussainMajed SaeedAtta Ur Rehman RanaKhizar Hayat GondalaAli Shandar DurraniMuhammad Raheem SajjadUniversity of FaisalabadarticleTransurethral Resection of Bladder TumorPyuriaTumor RecurrenceKisspeptinSpexin, Lipid ProfileObesityMedicineRENJournal of University Medical & Dental College, Vol 12, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Transurethral Resection of Bladder Tumor Pyuria Tumor Recurrence Kisspeptin Spexin, Lipid Profile Obesity Medicine R
spellingShingle	Transurethral Resection of Bladder Tumor Pyuria Tumor Recurrence Kisspeptin Spexin, Lipid Profile Obesity Medicine R Syed Atif Hussain Majed Saeed Atta Ur Rehman Rana Khizar Hayat Gondala Ali Shandar Durrani Muhammad Raheem Sajjad Pre-operative pyuria predicts tumor recurrence in patients undergoing transurethral resection of bladder tumor with post-operative instillation of BCG
description	BACKGROUND & OBJECTIVE: In Pakistan, urinary bladder cancer is one of the top ten malignancies. The most important concern after its treatment is tumor recurrence. Recent literature claimed that pre-operative pyuria in patients undergoing transurethral resection of bladder tumor was associated with significantly higher frequency of recurrence. However, there was controversy in existing literature and no such local published material was available which necessitated the present study. To determine the frequency of pre-operative pyuria in patients undergoing transurethral resection of bladder tumor for non-muscle invasive bladder cancer (NMIBC) with post-operative instillation of Bacillus Calmette Guerin (BCG) and to compare the frequency of tumor recurrence in patients with and without pre-operative pyuria. METHODOLOGY: It was a comparative study. This study involved 280 patients of both genders aged between 20-80 years. Pre-operative pyuria was diagnosed if early morning midstream urine specimen showed ≥10 white blood cells/HPF. Outcome variable was frequency of recurrence after 12 weeks of treatment on check cystoscopy. RESULTS: The mean age of the patients was 57.1±8.5 years. There were 236 (84.3%) male and 44 (15.7%) female patients in the study. 155 (55.4%) patients were tobacco smoker. Pre-operative pyuria was diagnosed in 127 (45.4%) patients while tumor recurrence was observed in 183 (65.4%) patients. The frequency of tumor recurrence was significantly higher in patients with pre-operative pyuria (85.8% vs. 48.4%; p<0.001). CONCLUSION: Pre-operative pyuria was a frequent finding in patients with non-muscle invasive bladder tumor and was associated with higher frequency of tumor recurrence which warrants routine screening of such patients for pyuria and increased frequency of tumor recurrence.
format	article
author	Syed Atif Hussain Majed Saeed Atta Ur Rehman Rana Khizar Hayat Gondala Ali Shandar Durrani Muhammad Raheem Sajjad
author_facet	Syed Atif Hussain Majed Saeed Atta Ur Rehman Rana Khizar Hayat Gondala Ali Shandar Durrani Muhammad Raheem Sajjad
author_sort	Syed Atif Hussain
title	Pre-operative pyuria predicts tumor recurrence in patients undergoing transurethral resection of bladder tumor with post-operative instillation of BCG
title_short	Pre-operative pyuria predicts tumor recurrence in patients undergoing transurethral resection of bladder tumor with post-operative instillation of BCG
title_full	Pre-operative pyuria predicts tumor recurrence in patients undergoing transurethral resection of bladder tumor with post-operative instillation of BCG
title_fullStr	Pre-operative pyuria predicts tumor recurrence in patients undergoing transurethral resection of bladder tumor with post-operative instillation of BCG
title_full_unstemmed	Pre-operative pyuria predicts tumor recurrence in patients undergoing transurethral resection of bladder tumor with post-operative instillation of BCG
title_sort	pre-operative pyuria predicts tumor recurrence in patients undergoing transurethral resection of bladder tumor with post-operative instillation of bcg
publisher	University of Faisalabad
publishDate	2021
url	https://doaj.org/article/afecbf9228a64731a889f05cc3a2c9de
work_keys_str_mv	AT syedatifhussain preoperativepyuriapredictstumorrecurrenceinpatientsundergoingtransurethralresectionofbladdertumorwithpostoperativeinstillationofbcg AT majedsaeed preoperativepyuriapredictstumorrecurrenceinpatientsundergoingtransurethralresectionofbladdertumorwithpostoperativeinstillationofbcg AT attaurrehmanrana preoperativepyuriapredictstumorrecurrenceinpatientsundergoingtransurethralresectionofbladdertumorwithpostoperativeinstillationofbcg AT khizarhayatgondala preoperativepyuriapredictstumorrecurrenceinpatientsundergoingtransurethralresectionofbladdertumorwithpostoperativeinstillationofbcg AT alishandardurrani preoperativepyuriapredictstumorrecurrenceinpatientsundergoingtransurethralresectionofbladdertumorwithpostoperativeinstillationofbcg AT muhammadraheemsajjad preoperativepyuriapredictstumorrecurrenceinpatientsundergoingtransurethralresectionofbladdertumorwithpostoperativeinstillationofbcg
_version_	1718408277971173376

Pre-operative pyuria predicts tumor recurrence in patients undergoing transurethral resection of bladder tumor with post-operative instillation of BCG

Ejemplares similares