Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia

Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia

There is increasing evidence that epigenetic mechanisms contribute to therapeutic resistance in cancer. Here the authors study AML patient samples and a mouse model of non-genetic resistance and find that transcriptional plasticity drives stable epigenetic resistance, and identify regulators of enha...

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Autores principales: Charles C. Bell, Katie A. Fennell, Yih-Chih Chan, Florian Rambow, Miriam M. Yeung, Dane Vassiliadis, Luis Lara, Paul Yeh, Luciano G. Martelotto, Aljosja Rogiers, Brandon E. Kremer, Olena Barbash, Helai P. Mohammad, Timothy M. Johanson, Marian L. Burr, Arindam Dhar, Natalie Karpinich, Luyi Tian, Dean S. Tyler, Laura MacPherson, Junwei Shi, Nathan Pinnawala, Chun Yew Fong, Anthony T. Papenfuss, Sean M. Grimmond, Sarah-Jane Dawson, Rhys S. Allan, Ryan G. Kruger, Christopher R. Vakoc, David L. Goode, Shalin H. Naik, Omer Gilan, Enid Y. N. Lam, Jean-Christophe Marine, Rab K. Prinjha, Mark A. Dawson
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/afef38c61db14a30844be963ce6499a0
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spelling oai:doaj.org-article:afef38c61db14a30844be963ce6499a02021-12-02T17:01:32ZTargeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia10.1038/s41467-019-10652-92041-1723https://doaj.org/article/afef38c61db14a30844be963ce6499a02019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10652-9https://doaj.org/toc/2041-1723There is increasing evidence that epigenetic mechanisms contribute to therapeutic resistance in cancer. Here the authors study AML patient samples and a mouse model of non-genetic resistance and find that transcriptional plasticity drives stable epigenetic resistance, and identify regulators of enhancer function as important modulators of resistance.Charles C. BellKatie A. FennellYih-Chih ChanFlorian RambowMiriam M. YeungDane VassiliadisLuis LaraPaul YehLuciano G. MartelottoAljosja RogiersBrandon E. KremerOlena BarbashHelai P. MohammadTimothy M. JohansonMarian L. BurrArindam DharNatalie KarpinichLuyi TianDean S. TylerLaura MacPhersonJunwei ShiNathan PinnawalaChun Yew FongAnthony T. PapenfussSean M. GrimmondSarah-Jane DawsonRhys S. AllanRyan G. KrugerChristopher R. VakocDavid L. GoodeShalin H. NaikOmer GilanEnid Y. N. LamJean-Christophe MarineRab K. PrinjhaMark A. DawsonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Charles C. Bell
Katie A. Fennell
Yih-Chih Chan
Florian Rambow
Miriam M. Yeung
Dane Vassiliadis
Luis Lara
Paul Yeh
Luciano G. Martelotto
Aljosja Rogiers
Brandon E. Kremer
Olena Barbash
Helai P. Mohammad
Timothy M. Johanson
Marian L. Burr
Arindam Dhar
Natalie Karpinich
Luyi Tian
Dean S. Tyler
Laura MacPherson
Junwei Shi
Nathan Pinnawala
Chun Yew Fong
Anthony T. Papenfuss
Sean M. Grimmond
Sarah-Jane Dawson
Rhys S. Allan
Ryan G. Kruger
Christopher R. Vakoc
David L. Goode
Shalin H. Naik
Omer Gilan
Enid Y. N. Lam
Jean-Christophe Marine
Rab K. Prinjha
Mark A. Dawson
Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
description There is increasing evidence that epigenetic mechanisms contribute to therapeutic resistance in cancer. Here the authors study AML patient samples and a mouse model of non-genetic resistance and find that transcriptional plasticity drives stable epigenetic resistance, and identify regulators of enhancer function as important modulators of resistance.
format article
author Charles C. Bell
Katie A. Fennell
Yih-Chih Chan
Florian Rambow
Miriam M. Yeung
Dane Vassiliadis
Luis Lara
Paul Yeh
Luciano G. Martelotto
Aljosja Rogiers
Brandon E. Kremer
Olena Barbash
Helai P. Mohammad
Timothy M. Johanson
Marian L. Burr
Arindam Dhar
Natalie Karpinich
Luyi Tian
Dean S. Tyler
Laura MacPherson
Junwei Shi
Nathan Pinnawala
Chun Yew Fong
Anthony T. Papenfuss
Sean M. Grimmond
Sarah-Jane Dawson
Rhys S. Allan
Ryan G. Kruger
Christopher R. Vakoc
David L. Goode
Shalin H. Naik
Omer Gilan
Enid Y. N. Lam
Jean-Christophe Marine
Rab K. Prinjha
Mark A. Dawson
author_facet Charles C. Bell
Katie A. Fennell
Yih-Chih Chan
Florian Rambow
Miriam M. Yeung
Dane Vassiliadis
Luis Lara
Paul Yeh
Luciano G. Martelotto
Aljosja Rogiers
Brandon E. Kremer
Olena Barbash
Helai P. Mohammad
Timothy M. Johanson
Marian L. Burr
Arindam Dhar
Natalie Karpinich
Luyi Tian
Dean S. Tyler
Laura MacPherson
Junwei Shi
Nathan Pinnawala
Chun Yew Fong
Anthony T. Papenfuss
Sean M. Grimmond
Sarah-Jane Dawson
Rhys S. Allan
Ryan G. Kruger
Christopher R. Vakoc
David L. Goode
Shalin H. Naik
Omer Gilan
Enid Y. N. Lam
Jean-Christophe Marine
Rab K. Prinjha
Mark A. Dawson
author_sort Charles C. Bell
title Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
title_short Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
title_full Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
title_fullStr Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
title_full_unstemmed Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
title_sort targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/afef38c61db14a30844be963ce6499a0
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