Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin

A feature of cohesin mutations in patients with Cornelia de Lange Syndrome (CdLS) is intellectual disability, but the underlying mechanisms have remained obscure. Here the authors show gene expression is deregulated in CdLS neurons and is recapitulated in a mouse model with cohesin depletion, which...

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Autores principales:	Felix D. Weiss, Lesly Calderon, Yi-Fang Wang, Radina Georgieva, Ya Guo, Nevena Cvetesic, Maninder Kaur, Gopuraja Dharmalingam, Ian D. Krantz, Boris Lenhard, Amanda G. Fisher, Matthias Merkenschlager
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/afef53aab6c24336822425f4c1c3c8be
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spelling	oai:doaj.org-article:afef53aab6c24336822425f4c1c3c8be2021-12-02T16:51:19ZNeuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin10.1038/s41467-021-23141-92041-1723https://doaj.org/article/afef53aab6c24336822425f4c1c3c8be2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23141-9https://doaj.org/toc/2041-1723A feature of cohesin mutations in patients with Cornelia de Lange Syndrome (CdLS) is intellectual disability, but the underlying mechanisms have remained obscure. Here the authors show gene expression is deregulated in CdLS neurons and is recapitulated in a mouse model with cohesin depletion, which can be restored by re-expression of cohesin.Felix D. WeissLesly CalderonYi-Fang WangRadina GeorgievaYa GuoNevena CvetesicManinder KaurGopuraja DharmalingamIan D. KrantzBoris LenhardAmanda G. FisherMatthias MerkenschlagerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Felix D. Weiss Lesly Calderon Yi-Fang Wang Radina Georgieva Ya Guo Nevena Cvetesic Maninder Kaur Gopuraja Dharmalingam Ian D. Krantz Boris Lenhard Amanda G. Fisher Matthias Merkenschlager Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin
description	A feature of cohesin mutations in patients with Cornelia de Lange Syndrome (CdLS) is intellectual disability, but the underlying mechanisms have remained obscure. Here the authors show gene expression is deregulated in CdLS neurons and is recapitulated in a mouse model with cohesin depletion, which can be restored by re-expression of cohesin.
format	article
author	Felix D. Weiss Lesly Calderon Yi-Fang Wang Radina Georgieva Ya Guo Nevena Cvetesic Maninder Kaur Gopuraja Dharmalingam Ian D. Krantz Boris Lenhard Amanda G. Fisher Matthias Merkenschlager
author_facet	Felix D. Weiss Lesly Calderon Yi-Fang Wang Radina Georgieva Ya Guo Nevena Cvetesic Maninder Kaur Gopuraja Dharmalingam Ian D. Krantz Boris Lenhard Amanda G. Fisher Matthias Merkenschlager
author_sort	Felix D. Weiss
title	Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin
title_short	Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin
title_full	Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin
title_fullStr	Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin
title_full_unstemmed	Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin
title_sort	neuronal genes deregulated in cornelia de lange syndrome respond to removal and re-expression of cohesin
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/afef53aab6c24336822425f4c1c3c8be
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Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin

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