Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin

Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin

A feature of cohesin mutations in patients with Cornelia de Lange Syndrome (CdLS) is intellectual disability, but the underlying mechanisms have remained obscure. Here the authors show gene expression is deregulated in CdLS neurons and is recapitulated in a mouse model with cohesin depletion, which...

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Main Authors: Felix D. Weiss, Lesly Calderon, Yi-Fang Wang, Radina Georgieva, Ya Guo, Nevena Cvetesic, Maninder Kaur, Gopuraja Dharmalingam, Ian D. Krantz, Boris Lenhard, Amanda G. Fisher, Matthias Merkenschlager
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/afef53aab6c24336822425f4c1c3c8be
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https://doaj.org/article/afef53aab6c24336822425f4c1c3c8be

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