A Significant Expansion of Our Understanding of the Composition of the Human Microbiome

ABSTRACT Shotgun sequencing of samples taken from the human microbiome often reveals only partial mapping of the sequenced metagenomic reads to existing reference genomes. Such partial mappability indicates that many genomes are missing in our reference genome set. This is particularly true for non-...

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Autores principales:	Sigal Leviatan, Eran Segal
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	genome assembly human microbiome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/aff1c2e360964056ac6205ac560b1fa7
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spelling	oai:doaj.org-article:aff1c2e360964056ac6205ac560b1fa72021-12-02T19:47:33ZA Significant Expansion of Our Understanding of the Composition of the Human Microbiome10.1128/mSystems.00010-192379-5077https://doaj.org/article/aff1c2e360964056ac6205ac560b1fa72019-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00010-19https://doaj.org/toc/2379-5077ABSTRACT Shotgun sequencing of samples taken from the human microbiome often reveals only partial mapping of the sequenced metagenomic reads to existing reference genomes. Such partial mappability indicates that many genomes are missing in our reference genome set. This is particularly true for non-Western populations and for samples that do not originate from the gut. Pasolli et al. (E. Pasolli, F. Asnicar, S. Manara, M. Zolfo, et al., Cell, 2019, https://doi.org/10.1016/j.cell.2019.01.001) perform a grand effort to expand the reference set, and to better classify its members, revealing a wider pangenome of existing species as well as identifying new species of previously unknown taxonomic branches.Sigal LeviatanEran SegalAmerican Society for Microbiologyarticlegenome assemblyhuman microbiomeMicrobiologyQR1-502ENmSystems, Vol 4, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	genome assembly human microbiome Microbiology QR1-502
spellingShingle	genome assembly human microbiome Microbiology QR1-502 Sigal Leviatan Eran Segal A Significant Expansion of Our Understanding of the Composition of the Human Microbiome
description	ABSTRACT Shotgun sequencing of samples taken from the human microbiome often reveals only partial mapping of the sequenced metagenomic reads to existing reference genomes. Such partial mappability indicates that many genomes are missing in our reference genome set. This is particularly true for non-Western populations and for samples that do not originate from the gut. Pasolli et al. (E. Pasolli, F. Asnicar, S. Manara, M. Zolfo, et al., Cell, 2019, https://doi.org/10.1016/j.cell.2019.01.001) perform a grand effort to expand the reference set, and to better classify its members, revealing a wider pangenome of existing species as well as identifying new species of previously unknown taxonomic branches.
format	article
author	Sigal Leviatan Eran Segal
author_facet	Sigal Leviatan Eran Segal
author_sort	Sigal Leviatan
title	A Significant Expansion of Our Understanding of the Composition of the Human Microbiome
title_short	A Significant Expansion of Our Understanding of the Composition of the Human Microbiome
title_full	A Significant Expansion of Our Understanding of the Composition of the Human Microbiome
title_fullStr	A Significant Expansion of Our Understanding of the Composition of the Human Microbiome
title_full_unstemmed	A Significant Expansion of Our Understanding of the Composition of the Human Microbiome
title_sort	significant expansion of our understanding of the composition of the human microbiome
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/aff1c2e360964056ac6205ac560b1fa7
work_keys_str_mv	AT sigalleviatan asignificantexpansionofourunderstandingofthecompositionofthehumanmicrobiome AT eransegal asignificantexpansionofourunderstandingofthecompositionofthehumanmicrobiome AT sigalleviatan significantexpansionofourunderstandingofthecompositionofthehumanmicrobiome AT eransegal significantexpansionofourunderstandingofthecompositionofthehumanmicrobiome
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A Significant Expansion of Our Understanding of the Composition of the Human Microbiome

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