Simple parameters predicting extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma

Abstract Extrahepatic recurrence (EHR) after curative hepatectomy for hepatocellular carcinoma (HCC) is associated with a poor prognosis. We investigated the features of EHR and identified its predictive factors. This retrospective study included 398 treatment-naive patients who underwent curative h...

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Autores principales:	Jae Hyun Yoon, Won Jae Lee, Sun Min Kim, Kwang Tack Kim, Sung Bum Cho, Hee Joon Kim, Yang Seok Ko, Hyun Yi Kook, Chung Hwan Jun, Sung Kyu Choi, Ban Seok Kim, Seo Yeon Cho, Hye-Su You, Yohan Lee, Seyeong Son
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aff2aa961e714e1aa60dd4a5ccb3ef18
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spelling	oai:doaj.org-article:aff2aa961e714e1aa60dd4a5ccb3ef182021-12-02T18:02:49ZSimple parameters predicting extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma10.1038/s41598-021-92503-62045-2322https://doaj.org/article/aff2aa961e714e1aa60dd4a5ccb3ef182021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92503-6https://doaj.org/toc/2045-2322Abstract Extrahepatic recurrence (EHR) after curative hepatectomy for hepatocellular carcinoma (HCC) is associated with a poor prognosis. We investigated the features of EHR and identified its predictive factors. This retrospective study included 398 treatment-naive patients who underwent curative hepatectomy for HCC at two tertiary hospitals. Multivariate Cox-regression analysis was performed to identify the variables associated with EHR. EHR was diagnosed in 94 patients (23.6%) over a median follow-up period of 5.92 years, most commonly in the lungs (42.6%). The 5-/10-year cumulative rates of HCC recurrence and EHR were 63.0%/75.6% and 18.1%/35.0%, respectively. The median time to EHR was 2.06 years. Intrahepatic HCC recurrence was not observed in 38.3% of patients on EHR diagnosis. On multivariate analysis, pathologic modified Union for International Cancer Control stage (III, IVa), surgical margin involvement, tumor necrosis, sum of tumor size > 7 cm, and macrovascular invasion were predictive factors of EHR. Four risk levels and their respective EHR rates were defined as follows: very low risk, 1-/5-year, 3.1%/11.6%; low risk, 1-/5-year, 12.0%/27.7%; intermediate risk, 1-/5-year, 36.3%/60.9%; and high risk, 1-year, 100.0%. Our predictive model clarifies the clinical course of EHR and could improve the follow-up strategy to improve outcomes.Jae Hyun YoonWon Jae LeeSun Min KimKwang Tack KimSung Bum ChoHee Joon KimYang Seok KoHyun Yi KookChung Hwan JunSung Kyu ChoiBan Seok KimSeo Yeon ChoHye-Su YouYohan LeeSeyeong SonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jae Hyun Yoon Won Jae Lee Sun Min Kim Kwang Tack Kim Sung Bum Cho Hee Joon Kim Yang Seok Ko Hyun Yi Kook Chung Hwan Jun Sung Kyu Choi Ban Seok Kim Seo Yeon Cho Hye-Su You Yohan Lee Seyeong Son Simple parameters predicting extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma
description	Abstract Extrahepatic recurrence (EHR) after curative hepatectomy for hepatocellular carcinoma (HCC) is associated with a poor prognosis. We investigated the features of EHR and identified its predictive factors. This retrospective study included 398 treatment-naive patients who underwent curative hepatectomy for HCC at two tertiary hospitals. Multivariate Cox-regression analysis was performed to identify the variables associated with EHR. EHR was diagnosed in 94 patients (23.6%) over a median follow-up period of 5.92 years, most commonly in the lungs (42.6%). The 5-/10-year cumulative rates of HCC recurrence and EHR were 63.0%/75.6% and 18.1%/35.0%, respectively. The median time to EHR was 2.06 years. Intrahepatic HCC recurrence was not observed in 38.3% of patients on EHR diagnosis. On multivariate analysis, pathologic modified Union for International Cancer Control stage (III, IVa), surgical margin involvement, tumor necrosis, sum of tumor size > 7 cm, and macrovascular invasion were predictive factors of EHR. Four risk levels and their respective EHR rates were defined as follows: very low risk, 1-/5-year, 3.1%/11.6%; low risk, 1-/5-year, 12.0%/27.7%; intermediate risk, 1-/5-year, 36.3%/60.9%; and high risk, 1-year, 100.0%. Our predictive model clarifies the clinical course of EHR and could improve the follow-up strategy to improve outcomes.
format	article
author	Jae Hyun Yoon Won Jae Lee Sun Min Kim Kwang Tack Kim Sung Bum Cho Hee Joon Kim Yang Seok Ko Hyun Yi Kook Chung Hwan Jun Sung Kyu Choi Ban Seok Kim Seo Yeon Cho Hye-Su You Yohan Lee Seyeong Son
author_facet	Jae Hyun Yoon Won Jae Lee Sun Min Kim Kwang Tack Kim Sung Bum Cho Hee Joon Kim Yang Seok Ko Hyun Yi Kook Chung Hwan Jun Sung Kyu Choi Ban Seok Kim Seo Yeon Cho Hye-Su You Yohan Lee Seyeong Son
author_sort	Jae Hyun Yoon
title	Simple parameters predicting extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma
title_short	Simple parameters predicting extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma
title_full	Simple parameters predicting extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma
title_fullStr	Simple parameters predicting extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma
title_full_unstemmed	Simple parameters predicting extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma
title_sort	simple parameters predicting extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aff2aa961e714e1aa60dd4a5ccb3ef18
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Simple parameters predicting extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma

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