Can simple intensification of therapy with modern two-phase insulin help in type 2 diabetes when target glycemia failed to be achieved withbasal insulin? Results of subanalysis in the PRESENT study

Aim. To evaluate efficiency and safety of intensification of therapy by substituting two-phase insulin aspart 30 (DiAsp 30) for basal insulin in patients with type2 diabetes mellitus after a failure to achieve target glycemia. Materials and methods. Analysis of the data obtained in a group of pati...

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Autores principales:	Ch S Yang, S Guler, Marina Vladimirovna Shestakova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	type 2 diabetes mellitus insulinotherapy two-phase insulin Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/aff4933c7a3245fa9b064abffc7f311e
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spelling	oai:doaj.org-article:aff4933c7a3245fa9b064abffc7f311e2021-11-14T09:00:14ZCan simple intensification of therapy with modern two-phase insulin help in type 2 diabetes when target glycemia failed to be achieved withbasal insulin? Results of subanalysis in the PRESENT study2072-03512072-037810.14341/2072-0351-5459https://doaj.org/article/aff4933c7a3245fa9b064abffc7f311e2009-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5459https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To evaluate efficiency and safety of intensification of therapy by substituting two-phase insulin aspart 30 (DiAsp 30) for basal insulin in patients with type2 diabetes mellitus after a failure to achieve target glycemia. Materials and methods. Analysis of the data obtained in a group of patients involved in the PRESENT study (Physicians Routine Evaluation of Safety andEfficacy of NovoMix 30 Therapy), a 6 month-long observational study conducted in 15 countries. The subanalysis included patients previously treated with along-acting insulin analog (AB, n=34) or intermediate and long-acting human basal insulin (HB, n=3414) and transferred thereafter to DiAsp 30 therapy.End-points of efficiency were the difference between blood HbА1c and glucose (fasting and postprandial) levels measured at the onset of the study and upon itscompletion, the number of hypoglycemic episodes and adverse events, physician and patients content with the results of the treatment. End-points were consideredseparately with reference to preceding basal therapy (AB or HB). Results. Treatment with DiAsp 30 for 6 months resulted in a fall of HbА1c levels compared with initial values (-1,60 and -142% in AB and HB patients respectively,pCh S YangS GulerMarina Vladimirovna ShestakovaEndocrinology Research Centrearticletype 2 diabetes mellitusinsulinotherapytwo-phase insulinNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 3, Pp 79-84 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes mellitus insulinotherapy two-phase insulin Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes mellitus insulinotherapy two-phase insulin Nutritional diseases. Deficiency diseases RC620-627 Ch S Yang S Guler Marina Vladimirovna Shestakova Can simple intensification of therapy with modern two-phase insulin help in type 2 diabetes when target glycemia failed to be achieved withbasal insulin? Results of subanalysis in the PRESENT study
description	Aim. To evaluate efficiency and safety of intensification of therapy by substituting two-phase insulin aspart 30 (DiAsp 30) for basal insulin in patients with type2 diabetes mellitus after a failure to achieve target glycemia. Materials and methods. Analysis of the data obtained in a group of patients involved in the PRESENT study (Physicians Routine Evaluation of Safety andEfficacy of NovoMix 30 Therapy), a 6 month-long observational study conducted in 15 countries. The subanalysis included patients previously treated with along-acting insulin analog (AB, n=34) or intermediate and long-acting human basal insulin (HB, n=3414) and transferred thereafter to DiAsp 30 therapy.End-points of efficiency were the difference between blood HbА1c and glucose (fasting and postprandial) levels measured at the onset of the study and upon itscompletion, the number of hypoglycemic episodes and adverse events, physician and patients content with the results of the treatment. End-points were consideredseparately with reference to preceding basal therapy (AB or HB). Results. Treatment with DiAsp 30 for 6 months resulted in a fall of HbА1c levels compared with initial values (-1,60 and -142% in AB and HB patients respectively,p
format	article
author	Ch S Yang S Guler Marina Vladimirovna Shestakova
author_facet	Ch S Yang S Guler Marina Vladimirovna Shestakova
author_sort	Ch S Yang
title	Can simple intensification of therapy with modern two-phase insulin help in type 2 diabetes when target glycemia failed to be achieved withbasal insulin? Results of subanalysis in the PRESENT study
title_short	Can simple intensification of therapy with modern two-phase insulin help in type 2 diabetes when target glycemia failed to be achieved withbasal insulin? Results of subanalysis in the PRESENT study
title_full	Can simple intensification of therapy with modern two-phase insulin help in type 2 diabetes when target glycemia failed to be achieved withbasal insulin? Results of subanalysis in the PRESENT study
title_fullStr	Can simple intensification of therapy with modern two-phase insulin help in type 2 diabetes when target glycemia failed to be achieved withbasal insulin? Results of subanalysis in the PRESENT study
title_full_unstemmed	Can simple intensification of therapy with modern two-phase insulin help in type 2 diabetes when target glycemia failed to be achieved withbasal insulin? Results of subanalysis in the PRESENT study
title_sort	can simple intensification of therapy with modern two-phase insulin help in type 2 diabetes when target glycemia failed to be achieved withbasal insulin? results of subanalysis in the present study
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/aff4933c7a3245fa9b064abffc7f311e
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Can simple intensification of therapy with modern two-phase insulin help in type 2 diabetes when target glycemia failed to be achieved withbasal insulin? Results of subanalysis in the PRESENT study

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