Vitamin D deficiency and posterior subcapsular cataract
Craig J Brown,1 Faical Akaichi21The Eye Center, Fayetteville, AR, USA; 2Scotland’s Rural College, Edinburgh, UKPurpose: To evaluate risk factors associated with posterior subcapsular cataract (PSC) development and the relationship between vitamin D deficiency and etiology of PSC.Methods: O...
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2015
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/aff7110fcb0a4a9ead0856644cae4481 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:aff7110fcb0a4a9ead0856644cae4481 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:aff7110fcb0a4a9ead0856644cae44812021-12-02T01:47:50ZVitamin D deficiency and posterior subcapsular cataract1177-5483https://doaj.org/article/aff7110fcb0a4a9ead0856644cae44812015-06-01T00:00:00Zhttp://www.dovepress.com/vitamin-d-deficiency-and-posterior-subcapsular-cataract-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Craig J Brown,1 Faical Akaichi21The Eye Center, Fayetteville, AR, USA; 2Scotland’s Rural College, Edinburgh, UKPurpose: To evaluate risk factors associated with posterior subcapsular cataract (PSC) development and the relationship between vitamin D deficiency and etiology of PSC.Methods: Of 195 consecutive patients from a private ophthalmology practice, diagnosed with PSC, serum vitamin D3 (25-OH D) levels were obtained for 175, and associations among risk factors, comorbidities, and PSC were assessed.Results: In all 175 PSC patients, mean 25-OH D levels were low (24 ng/mL ±11 SD) compared with age/sex-matched standards. Significant differences in 25-OH D levels were noted between PSC subjects taking/not taking calcium supplements, systemic steroids, osteoporosis medications, etc. Alone, smoking status and calcium channel blockers and/or topical steroids use made no significant difference in PSC subjects 25-OH D levels, but two or more of these factors were associated with lowered levels of 25-OH D (P<0.001). Low vitamin D was correlated with female sex, autoimmune disease, and non-skin cancer diagnosis, but not with age, or other comorbidities or medication use. In five early-stage PSC patients taking 5,000 IU of 25-OH D daily for vitamin D deficiency, there was resolution of their cataracts during the 2-year follow-up period.Conclusion: Vitamin D levels for most PSC patients fell below the 30 ng/mL calcium homeostasis threshold. Some comorbidities and non-ophthalmic interventions are associated with the development of PSC at less depressed levels of 25-OH D. In this series, vitamin D deficiency was associated with PSC cataract, suggesting that raising the level of vitamin D intake may reduce PSC incidence.Keywords: posterior subcapsular, cataracts, vitamin D deficiency, risk factors, hypocalcemia, case reportBrown CJAkaichi FDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 1093-1098 (2015) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Ophthalmology RE1-994 |
| spellingShingle |
Ophthalmology RE1-994 Brown CJ Akaichi F Vitamin D deficiency and posterior subcapsular cataract |
| description |
Craig J Brown,1 Faical Akaichi21The Eye Center, Fayetteville, AR, USA; 2Scotland’s Rural College, Edinburgh, UKPurpose: To evaluate risk factors associated with posterior subcapsular cataract (PSC) development and the relationship between vitamin D deficiency and etiology of PSC.Methods: Of 195 consecutive patients from a private ophthalmology practice, diagnosed with PSC, serum vitamin D3 (25-OH D) levels were obtained for 175, and associations among risk factors, comorbidities, and PSC were assessed.Results: In all 175 PSC patients, mean 25-OH D levels were low (24 ng/mL ±11 SD) compared with age/sex-matched standards. Significant differences in 25-OH D levels were noted between PSC subjects taking/not taking calcium supplements, systemic steroids, osteoporosis medications, etc. Alone, smoking status and calcium channel blockers and/or topical steroids use made no significant difference in PSC subjects 25-OH D levels, but two or more of these factors were associated with lowered levels of 25-OH D (P<0.001). Low vitamin D was correlated with female sex, autoimmune disease, and non-skin cancer diagnosis, but not with age, or other comorbidities or medication use. In five early-stage PSC patients taking 5,000 IU of 25-OH D daily for vitamin D deficiency, there was resolution of their cataracts during the 2-year follow-up period.Conclusion: Vitamin D levels for most PSC patients fell below the 30 ng/mL calcium homeostasis threshold. Some comorbidities and non-ophthalmic interventions are associated with the development of PSC at less depressed levels of 25-OH D. In this series, vitamin D deficiency was associated with PSC cataract, suggesting that raising the level of vitamin D intake may reduce PSC incidence.Keywords: posterior subcapsular, cataracts, vitamin D deficiency, risk factors, hypocalcemia, case report |
| format |
article |
| author |
Brown CJ Akaichi F |
| author_facet |
Brown CJ Akaichi F |
| author_sort |
Brown CJ |
| title |
Vitamin D deficiency and posterior subcapsular cataract |
| title_short |
Vitamin D deficiency and posterior subcapsular cataract |
| title_full |
Vitamin D deficiency and posterior subcapsular cataract |
| title_fullStr |
Vitamin D deficiency and posterior subcapsular cataract |
| title_full_unstemmed |
Vitamin D deficiency and posterior subcapsular cataract |
| title_sort |
vitamin d deficiency and posterior subcapsular cataract |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/aff7110fcb0a4a9ead0856644cae4481 |
| work_keys_str_mv |
AT browncj vitaminddeficiencyandposteriorsubcapsularcataract AT akaichif vitaminddeficiencyandposteriorsubcapsularcataract |
| _version_ |
1718402917473452032 |