Down Syndrome in Brazil: Occurrence and Associated Factors

Background: Down syndrome is the most frequent genetic cause of intellectual disability, with an estimated birth prevalence of 14 per 10,000 live births. In Brazil, statistical data on the occurrence of babies born with Down syndrome remain unclear. We aimed to estimate the occurrence of Down syndro...

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Autores principales: Mariana Rabello Laignier, Luís Carlos Lopes-Júnior, Raquel Esperidon Santana, Franciéle Marabotti Costa Leite, Carolina Laura Brancato
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Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/aff8e407b15241c882a36a135829cad7
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spelling oai:doaj.org-article:aff8e407b15241c882a36a135829cad72021-11-25T17:49:46ZDown Syndrome in Brazil: Occurrence and Associated Factors10.3390/ijerph1822119541660-46011661-7827https://doaj.org/article/aff8e407b15241c882a36a135829cad72021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/11954https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Background: Down syndrome is the most frequent genetic cause of intellectual disability, with an estimated birth prevalence of 14 per 10,000 live births. In Brazil, statistical data on the occurrence of babies born with Down syndrome remain unclear. We aimed to estimate the occurrence of Down syndrome between 2012 and 2018, and to observe its association with maternal, gestational, paternal characteristics, and newborn vitality. Methods: A retrospective study was carried out using secondary data included in the Certificate of Live Birth in a state located in the southeastern region of Brazil. Data analysis was performed in the software Stata 14.1. Pearson’s chi-square test for bivariate analysis, and logistic regression for multivariate analysis were performed, with a 95% confidence interval (CI) and a significance of 5%. Results: We observed that 157 cases of Down syndrome were reported among 386,571 live births, representing an incidence of 4 in 10,000 live births. Down syndrome was associated with maternal age ≥ 35 years, paternal age ≥ 30 years, the performance of six or more prenatal consultations, prematurity, and low birth weight (<i>p</i> < 0.05). Conclusions: Women aged 35 and over were more likely to have children born with Down syndrome. In addition, there is an association of Down syndrome with premature birth, low birth weight, and the number of prenatal consultations (≥6).Mariana Rabello LaignierLuís Carlos Lopes-JúniorRaquel Esperidon SantanaFranciéle Marabotti Costa LeiteCarolina Laura BrancatoMDPI AGarticleDown syndromenewborncertificate of live birthinformation systemschild healthepidemiologyMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11954, p 11954 (2021)
institution DOAJ
collection DOAJ
language EN
topic Down syndrome
newborn
certificate of live birth
information systems
child health
epidemiology
Medicine
R
spellingShingle Down syndrome
newborn
certificate of live birth
information systems
child health
epidemiology
Medicine
R
Mariana Rabello Laignier
Luís Carlos Lopes-Júnior
Raquel Esperidon Santana
Franciéle Marabotti Costa Leite
Carolina Laura Brancato
Down Syndrome in Brazil: Occurrence and Associated Factors
description Background: Down syndrome is the most frequent genetic cause of intellectual disability, with an estimated birth prevalence of 14 per 10,000 live births. In Brazil, statistical data on the occurrence of babies born with Down syndrome remain unclear. We aimed to estimate the occurrence of Down syndrome between 2012 and 2018, and to observe its association with maternal, gestational, paternal characteristics, and newborn vitality. Methods: A retrospective study was carried out using secondary data included in the Certificate of Live Birth in a state located in the southeastern region of Brazil. Data analysis was performed in the software Stata 14.1. Pearson’s chi-square test for bivariate analysis, and logistic regression for multivariate analysis were performed, with a 95% confidence interval (CI) and a significance of 5%. Results: We observed that 157 cases of Down syndrome were reported among 386,571 live births, representing an incidence of 4 in 10,000 live births. Down syndrome was associated with maternal age ≥ 35 years, paternal age ≥ 30 years, the performance of six or more prenatal consultations, prematurity, and low birth weight (<i>p</i> < 0.05). Conclusions: Women aged 35 and over were more likely to have children born with Down syndrome. In addition, there is an association of Down syndrome with premature birth, low birth weight, and the number of prenatal consultations (≥6).
format article
author Mariana Rabello Laignier
Luís Carlos Lopes-Júnior
Raquel Esperidon Santana
Franciéle Marabotti Costa Leite
Carolina Laura Brancato
author_facet Mariana Rabello Laignier
Luís Carlos Lopes-Júnior
Raquel Esperidon Santana
Franciéle Marabotti Costa Leite
Carolina Laura Brancato
author_sort Mariana Rabello Laignier
title Down Syndrome in Brazil: Occurrence and Associated Factors
title_short Down Syndrome in Brazil: Occurrence and Associated Factors
title_full Down Syndrome in Brazil: Occurrence and Associated Factors
title_fullStr Down Syndrome in Brazil: Occurrence and Associated Factors
title_full_unstemmed Down Syndrome in Brazil: Occurrence and Associated Factors
title_sort down syndrome in brazil: occurrence and associated factors
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/aff8e407b15241c882a36a135829cad7
work_keys_str_mv AT marianarabellolaignier downsyndromeinbraziloccurrenceandassociatedfactors
AT luiscarloslopesjunior downsyndromeinbraziloccurrenceandassociatedfactors
AT raquelesperidonsantana downsyndromeinbraziloccurrenceandassociatedfactors
AT francielemarabotticostaleite downsyndromeinbraziloccurrenceandassociatedfactors
AT carolinalaurabrancato downsyndromeinbraziloccurrenceandassociatedfactors
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