Down Syndrome in Brazil: Occurrence and Associated Factors

Background: Down syndrome is the most frequent genetic cause of intellectual disability, with an estimated birth prevalence of 14 per 10,000 live births. In Brazil, statistical data on the occurrence of babies born with Down syndrome remain unclear. We aimed to estimate the occurrence of Down syndro...

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Autores principales:	Mariana Rabello Laignier, Luís Carlos Lopes-Júnior, Raquel Esperidon Santana, Franciéle Marabotti Costa Leite, Carolina Laura Brancato
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Down syndrome newborn certificate of live birth information systems child health epidemiology Medicine R
Acceso en línea:	https://doaj.org/article/aff8e407b15241c882a36a135829cad7
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spelling	oai:doaj.org-article:aff8e407b15241c882a36a135829cad72021-11-25T17:49:46ZDown Syndrome in Brazil: Occurrence and Associated Factors10.3390/ijerph1822119541660-46011661-7827https://doaj.org/article/aff8e407b15241c882a36a135829cad72021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/11954https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Background: Down syndrome is the most frequent genetic cause of intellectual disability, with an estimated birth prevalence of 14 per 10,000 live births. In Brazil, statistical data on the occurrence of babies born with Down syndrome remain unclear. We aimed to estimate the occurrence of Down syndrome between 2012 and 2018, and to observe its association with maternal, gestational, paternal characteristics, and newborn vitality. Methods: A retrospective study was carried out using secondary data included in the Certificate of Live Birth in a state located in the southeastern region of Brazil. Data analysis was performed in the software Stata 14.1. Pearson’s chi-square test for bivariate analysis, and logistic regression for multivariate analysis were performed, with a 95% confidence interval (CI) and a significance of 5%. Results: We observed that 157 cases of Down syndrome were reported among 386,571 live births, representing an incidence of 4 in 10,000 live births. Down syndrome was associated with maternal age ≥ 35 years, paternal age ≥ 30 years, the performance of six or more prenatal consultations, prematurity, and low birth weight (<i>p</i> < 0.05). Conclusions: Women aged 35 and over were more likely to have children born with Down syndrome. In addition, there is an association of Down syndrome with premature birth, low birth weight, and the number of prenatal consultations (≥6).Mariana Rabello LaignierLuís Carlos Lopes-JúniorRaquel Esperidon SantanaFranciéle Marabotti Costa LeiteCarolina Laura BrancatoMDPI AGarticleDown syndromenewborncertificate of live birthinformation systemschild healthepidemiologyMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11954, p 11954 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Down syndrome newborn certificate of live birth information systems child health epidemiology Medicine R
spellingShingle	Down syndrome newborn certificate of live birth information systems child health epidemiology Medicine R Mariana Rabello Laignier Luís Carlos Lopes-Júnior Raquel Esperidon Santana Franciéle Marabotti Costa Leite Carolina Laura Brancato Down Syndrome in Brazil: Occurrence and Associated Factors
description	Background: Down syndrome is the most frequent genetic cause of intellectual disability, with an estimated birth prevalence of 14 per 10,000 live births. In Brazil, statistical data on the occurrence of babies born with Down syndrome remain unclear. We aimed to estimate the occurrence of Down syndrome between 2012 and 2018, and to observe its association with maternal, gestational, paternal characteristics, and newborn vitality. Methods: A retrospective study was carried out using secondary data included in the Certificate of Live Birth in a state located in the southeastern region of Brazil. Data analysis was performed in the software Stata 14.1. Pearson’s chi-square test for bivariate analysis, and logistic regression for multivariate analysis were performed, with a 95% confidence interval (CI) and a significance of 5%. Results: We observed that 157 cases of Down syndrome were reported among 386,571 live births, representing an incidence of 4 in 10,000 live births. Down syndrome was associated with maternal age ≥ 35 years, paternal age ≥ 30 years, the performance of six or more prenatal consultations, prematurity, and low birth weight (<i>p</i> < 0.05). Conclusions: Women aged 35 and over were more likely to have children born with Down syndrome. In addition, there is an association of Down syndrome with premature birth, low birth weight, and the number of prenatal consultations (≥6).
format	article
author	Mariana Rabello Laignier Luís Carlos Lopes-Júnior Raquel Esperidon Santana Franciéle Marabotti Costa Leite Carolina Laura Brancato
author_facet	Mariana Rabello Laignier Luís Carlos Lopes-Júnior Raquel Esperidon Santana Franciéle Marabotti Costa Leite Carolina Laura Brancato
author_sort	Mariana Rabello Laignier
title	Down Syndrome in Brazil: Occurrence and Associated Factors
title_short	Down Syndrome in Brazil: Occurrence and Associated Factors
title_full	Down Syndrome in Brazil: Occurrence and Associated Factors
title_fullStr	Down Syndrome in Brazil: Occurrence and Associated Factors
title_full_unstemmed	Down Syndrome in Brazil: Occurrence and Associated Factors
title_sort	down syndrome in brazil: occurrence and associated factors
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/aff8e407b15241c882a36a135829cad7
work_keys_str_mv	AT marianarabellolaignier downsyndromeinbraziloccurrenceandassociatedfactors AT luiscarloslopesjunior downsyndromeinbraziloccurrenceandassociatedfactors AT raquelesperidonsantana downsyndromeinbraziloccurrenceandassociatedfactors AT francielemarabotticostaleite downsyndromeinbraziloccurrenceandassociatedfactors AT carolinalaurabrancato downsyndromeinbraziloccurrenceandassociatedfactors
_version_	1718412005503664128

Down Syndrome in Brazil: Occurrence and Associated Factors

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