Motor signatures of emotional reactivity in frontotemporal dementia

Abstract Automatic motor mimicry is essential to the normal processing of perceived emotion, and disrupted automatic imitation might underpin socio-emotional deficits in neurodegenerative diseases, particularly the frontotemporal dementias. However, the pathophysiology of emotional reactivity in the...

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Autores principales:	Charles R. Marshall, Chris J. D. Hardy, Lucy L. Russell, Camilla N. Clark, Rebecca L. Bond, Katrina M. Dick, Emilie V. Brotherhood, Cath J. Mummery, Jonathan M. Schott, Jonathan D. Rohrer, James M. Kilner, Jason D. Warren
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/affe7645504d492b9b80b54899f603aa
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spelling	oai:doaj.org-article:affe7645504d492b9b80b54899f603aa2021-12-02T15:08:16ZMotor signatures of emotional reactivity in frontotemporal dementia10.1038/s41598-018-19528-22045-2322https://doaj.org/article/affe7645504d492b9b80b54899f603aa2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19528-2https://doaj.org/toc/2045-2322Abstract Automatic motor mimicry is essential to the normal processing of perceived emotion, and disrupted automatic imitation might underpin socio-emotional deficits in neurodegenerative diseases, particularly the frontotemporal dementias. However, the pathophysiology of emotional reactivity in these diseases has not been elucidated. We studied facial electromyographic responses during emotion identification on viewing videos of dynamic facial expressions in 37 patients representing canonical frontotemporal dementia syndromes versus 21 healthy older individuals. Neuroanatomical associations of emotional expression identification accuracy and facial muscle reactivity were assessed using voxel-based morphometry. Controls showed characteristic profiles of automatic imitation, and this response predicted correct emotion identification. Automatic imitation was reduced in the behavioural and right temporal variant groups, while the normal coupling between imitation and correct identification was lost in the right temporal and semantic variant groups. Grey matter correlates of emotion identification and imitation were delineated within a distributed network including primary visual and motor, prefrontal, insular, anterior temporal and temporo-occipital junctional areas, with common involvement of supplementary motor cortex across syndromes. Impaired emotional mimesis may be a core mechanism of disordered emotional signal understanding and reactivity in frontotemporal dementia, with implications for the development of novel physiological biomarkers of socio-emotional dysfunction in these diseases.Charles R. MarshallChris J. D. HardyLucy L. RussellCamilla N. ClarkRebecca L. BondKatrina M. DickEmilie V. BrotherhoodCath J. MummeryJonathan M. SchottJonathan D. RohrerJames M. KilnerJason D. WarrenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Charles R. Marshall Chris J. D. Hardy Lucy L. Russell Camilla N. Clark Rebecca L. Bond Katrina M. Dick Emilie V. Brotherhood Cath J. Mummery Jonathan M. Schott Jonathan D. Rohrer James M. Kilner Jason D. Warren Motor signatures of emotional reactivity in frontotemporal dementia
description	Abstract Automatic motor mimicry is essential to the normal processing of perceived emotion, and disrupted automatic imitation might underpin socio-emotional deficits in neurodegenerative diseases, particularly the frontotemporal dementias. However, the pathophysiology of emotional reactivity in these diseases has not been elucidated. We studied facial electromyographic responses during emotion identification on viewing videos of dynamic facial expressions in 37 patients representing canonical frontotemporal dementia syndromes versus 21 healthy older individuals. Neuroanatomical associations of emotional expression identification accuracy and facial muscle reactivity were assessed using voxel-based morphometry. Controls showed characteristic profiles of automatic imitation, and this response predicted correct emotion identification. Automatic imitation was reduced in the behavioural and right temporal variant groups, while the normal coupling between imitation and correct identification was lost in the right temporal and semantic variant groups. Grey matter correlates of emotion identification and imitation were delineated within a distributed network including primary visual and motor, prefrontal, insular, anterior temporal and temporo-occipital junctional areas, with common involvement of supplementary motor cortex across syndromes. Impaired emotional mimesis may be a core mechanism of disordered emotional signal understanding and reactivity in frontotemporal dementia, with implications for the development of novel physiological biomarkers of socio-emotional dysfunction in these diseases.
format	article
author	Charles R. Marshall Chris J. D. Hardy Lucy L. Russell Camilla N. Clark Rebecca L. Bond Katrina M. Dick Emilie V. Brotherhood Cath J. Mummery Jonathan M. Schott Jonathan D. Rohrer James M. Kilner Jason D. Warren
author_facet	Charles R. Marshall Chris J. D. Hardy Lucy L. Russell Camilla N. Clark Rebecca L. Bond Katrina M. Dick Emilie V. Brotherhood Cath J. Mummery Jonathan M. Schott Jonathan D. Rohrer James M. Kilner Jason D. Warren
author_sort	Charles R. Marshall
title	Motor signatures of emotional reactivity in frontotemporal dementia
title_short	Motor signatures of emotional reactivity in frontotemporal dementia
title_full	Motor signatures of emotional reactivity in frontotemporal dementia
title_fullStr	Motor signatures of emotional reactivity in frontotemporal dementia
title_full_unstemmed	Motor signatures of emotional reactivity in frontotemporal dementia
title_sort	motor signatures of emotional reactivity in frontotemporal dementia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/affe7645504d492b9b80b54899f603aa
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Motor signatures of emotional reactivity in frontotemporal dementia

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