Structural basis for late maturation steps of the human mitoribosomal large subunit

Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as...

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Autores principales:	Miriam Cipullo, Genís Valentín Gesé, Anas Khawaja, B. Martin Hällberg, Joanna Rorbach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/afff746beaad42ec9209fdaff85ed8ec
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spelling	oai:doaj.org-article:afff746beaad42ec9209fdaff85ed8ec2021-12-02T16:04:21ZStructural basis for late maturation steps of the human mitoribosomal large subunit10.1038/s41467-021-23617-82041-1723https://doaj.org/article/afff746beaad42ec9209fdaff85ed8ec2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23617-8https://doaj.org/toc/2041-1723Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as well as functions of several mitoribosome assembly factors.Miriam CipulloGenís Valentín GeséAnas KhawajaB. Martin HällbergJoanna RorbachNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Miriam Cipullo Genís Valentín Gesé Anas Khawaja B. Martin Hällberg Joanna Rorbach Structural basis for late maturation steps of the human mitoribosomal large subunit
description	Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as well as functions of several mitoribosome assembly factors.
format	article
author	Miriam Cipullo Genís Valentín Gesé Anas Khawaja B. Martin Hällberg Joanna Rorbach
author_facet	Miriam Cipullo Genís Valentín Gesé Anas Khawaja B. Martin Hällberg Joanna Rorbach
author_sort	Miriam Cipullo
title	Structural basis for late maturation steps of the human mitoribosomal large subunit
title_short	Structural basis for late maturation steps of the human mitoribosomal large subunit
title_full	Structural basis for late maturation steps of the human mitoribosomal large subunit
title_fullStr	Structural basis for late maturation steps of the human mitoribosomal large subunit
title_full_unstemmed	Structural basis for late maturation steps of the human mitoribosomal large subunit
title_sort	structural basis for late maturation steps of the human mitoribosomal large subunit
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/afff746beaad42ec9209fdaff85ed8ec
work_keys_str_mv	AT miriamcipullo structuralbasisforlatematurationstepsofthehumanmitoribosomallargesubunit AT genisvalentingese structuralbasisforlatematurationstepsofthehumanmitoribosomallargesubunit AT anaskhawaja structuralbasisforlatematurationstepsofthehumanmitoribosomallargesubunit AT bmartinhallberg structuralbasisforlatematurationstepsofthehumanmitoribosomallargesubunit AT joannarorbach structuralbasisforlatematurationstepsofthehumanmitoribosomallargesubunit
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Structural basis for late maturation steps of the human mitoribosomal large subunit

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