Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells

How downstream regulators of Wnt/β-catenin signalling control the fate of intestinal epithelial stem cells (IESCs) is unclear. Here, the authors show that the transcriptional co-factors interacting with the N- and C-terminal domains of β-catenin differentially regulate Wnt target gene activation, in...

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Autores principales:	Costanza Borrelli, Tomas Valenta, Kristina Handler, Karelia Vélez, Alessandra Gurtner, Giulia Moro, Atefeh Lafzi, Laura de Vargas Roditi, George Hausmann, Isabelle C. Arnold, Andreas E. Moor, Konrad Basler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b000084e9fe54599bffafb79714d42b4
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spelling	oai:doaj.org-article:b000084e9fe54599bffafb79714d42b42021-12-02T13:33:09ZDifferential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells10.1038/s41467-021-21591-92041-1723https://doaj.org/article/b000084e9fe54599bffafb79714d42b42021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21591-9https://doaj.org/toc/2041-1723How downstream regulators of Wnt/β-catenin signalling control the fate of intestinal epithelial stem cells (IESCs) is unclear. Here, the authors show that the transcriptional co-factors interacting with the N- and C-terminal domains of β-catenin differentially regulate Wnt target gene activation, in turn differentially affecting the murine IESC proliferation and differentiation.Costanza BorrelliTomas ValentaKristina HandlerKarelia VélezAlessandra GurtnerGiulia MoroAtefeh LafziLaura de Vargas RoditiGeorge HausmannIsabelle C. ArnoldAndreas E. MoorKonrad BaslerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Costanza Borrelli Tomas Valenta Kristina Handler Karelia Vélez Alessandra Gurtner Giulia Moro Atefeh Lafzi Laura de Vargas Roditi George Hausmann Isabelle C. Arnold Andreas E. Moor Konrad Basler Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells
description	How downstream regulators of Wnt/β-catenin signalling control the fate of intestinal epithelial stem cells (IESCs) is unclear. Here, the authors show that the transcriptional co-factors interacting with the N- and C-terminal domains of β-catenin differentially regulate Wnt target gene activation, in turn differentially affecting the murine IESC proliferation and differentiation.
format	article
author	Costanza Borrelli Tomas Valenta Kristina Handler Karelia Vélez Alessandra Gurtner Giulia Moro Atefeh Lafzi Laura de Vargas Roditi George Hausmann Isabelle C. Arnold Andreas E. Moor Konrad Basler
author_facet	Costanza Borrelli Tomas Valenta Kristina Handler Karelia Vélez Alessandra Gurtner Giulia Moro Atefeh Lafzi Laura de Vargas Roditi George Hausmann Isabelle C. Arnold Andreas E. Moor Konrad Basler
author_sort	Costanza Borrelli
title	Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells
title_short	Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells
title_full	Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells
title_fullStr	Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells
title_full_unstemmed	Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells
title_sort	differential regulation of β-catenin-mediated transcription via n- and c-terminal co-factors governs identity of murine intestinal epithelial stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b000084e9fe54599bffafb79714d42b4
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Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells

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