Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells

Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells

How downstream regulators of Wnt/β-catenin signalling control the fate of intestinal epithelial stem cells (IESCs) is unclear. Here, the authors show that the transcriptional co-factors interacting with the N- and C-terminal domains of β-catenin differentially regulate Wnt target gene activation, in...

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Autores principales: Costanza Borrelli, Tomas Valenta, Kristina Handler, Karelia Vélez, Alessandra Gurtner, Giulia Moro, Atefeh Lafzi, Laura de Vargas Roditi, George Hausmann, Isabelle C. Arnold, Andreas E. Moor, Konrad Basler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/b000084e9fe54599bffafb79714d42b4
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