Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China

Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China

Abstract CYP24A1 and CYP27B1 are critical genes determining 1α,25(OH)2D3 concentration and impacting on carcinogenesis. A case–control study including 528 colorectal cancer (CRC) patients and 605 cancer-free controls and a follow-up study with 317 cases were conducted in northeast China. Genotypes w...

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Autores principales: Chen Gong, Zhiping Long, Yanming Yu, Lin Zhu, Jingshen Tian, Shuo Li, Jing Li, Hongyuan Yu, Qiang Chi, Daxun Piao, Fan Wang, Yashuang Zhao, Binbin Cui
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b0010cebf49a45be8aa3be8425639947
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spelling oai:doaj.org-article:b0010cebf49a45be8aa3be84256399472021-12-02T16:06:34ZDietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China10.1038/s41598-017-09356-12045-2322https://doaj.org/article/b0010cebf49a45be8aa3be84256399472017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09356-1https://doaj.org/toc/2045-2322Abstract CYP24A1 and CYP27B1 are critical genes determining 1α,25(OH)2D3 concentration and impacting on carcinogenesis. A case–control study including 528 colorectal cancer (CRC) patients and 605 cancer-free controls and a follow-up study with 317 cases were conducted in northeast China. Genotypes were tested by TaqMan Genotyping Assays. Individuals carrying the GG genotype of CYP27B1 G > T (rs10877012) exhibited decreased CRC risk compared with those with the TT genotype (ORadjusted (ORadj) = 0.57, 95% Confidence Interval (CI) = 0.38–0.84). Compared with the TT genotype, a significant association between the CC genotype of CYP27B1 C > T (rs4646536) and a reduced risk of CRC was observed (ORadj = 0.59, 95% CI = 0.40–0.88). We also observed significant combined effects of the two polymorphisms in CYP27B1 with dietary factors, including the intake of cereals, overnight meal, allium vegetables, pork, canned fruit, and braised fish, on CRC risk. These associations remained significant after Bonferroni correction for multiple comparisons. The Hazard Ration (HR) of patients with the AA genotype (CYP24A1 A > G, rs4809957) was 2.38 (95% CI = 1.30–4.37) when compared with the GG genotype. Thus, our findings suggested that two polymorphisms in CYP27B1 are associated with CRC susceptibility. CYP24A1 A > G (rs4809957) polymorphism may lead to a worse prognosis of CRC.Chen GongZhiping LongYanming YuLin ZhuJingshen TianShuo LiJing LiHongyuan YuQiang ChiDaxun PiaoFan WangYashuang ZhaoBinbin CuiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Chen Gong
Zhiping Long
Yanming Yu
Lin Zhu
Jingshen Tian
Shuo Li
Jing Li
Hongyuan Yu
Qiang Chi
Daxun Piao
Fan Wang
Yashuang Zhao
Binbin Cui
Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China
description Abstract CYP24A1 and CYP27B1 are critical genes determining 1α,25(OH)2D3 concentration and impacting on carcinogenesis. A case–control study including 528 colorectal cancer (CRC) patients and 605 cancer-free controls and a follow-up study with 317 cases were conducted in northeast China. Genotypes were tested by TaqMan Genotyping Assays. Individuals carrying the GG genotype of CYP27B1 G > T (rs10877012) exhibited decreased CRC risk compared with those with the TT genotype (ORadjusted (ORadj) = 0.57, 95% Confidence Interval (CI) = 0.38–0.84). Compared with the TT genotype, a significant association between the CC genotype of CYP27B1 C > T (rs4646536) and a reduced risk of CRC was observed (ORadj = 0.59, 95% CI = 0.40–0.88). We also observed significant combined effects of the two polymorphisms in CYP27B1 with dietary factors, including the intake of cereals, overnight meal, allium vegetables, pork, canned fruit, and braised fish, on CRC risk. These associations remained significant after Bonferroni correction for multiple comparisons. The Hazard Ration (HR) of patients with the AA genotype (CYP24A1 A > G, rs4809957) was 2.38 (95% CI = 1.30–4.37) when compared with the GG genotype. Thus, our findings suggested that two polymorphisms in CYP27B1 are associated with CRC susceptibility. CYP24A1 A > G (rs4809957) polymorphism may lead to a worse prognosis of CRC.
format article
author Chen Gong
Zhiping Long
Yanming Yu
Lin Zhu
Jingshen Tian
Shuo Li
Jing Li
Hongyuan Yu
Qiang Chi
Daxun Piao
Fan Wang
Yashuang Zhao
Binbin Cui
author_facet Chen Gong
Zhiping Long
Yanming Yu
Lin Zhu
Jingshen Tian
Shuo Li
Jing Li
Hongyuan Yu
Qiang Chi
Daxun Piao
Fan Wang
Yashuang Zhao
Binbin Cui
author_sort Chen Gong
title Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China
title_short Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China
title_full Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China
title_fullStr Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China
title_full_unstemmed Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China
title_sort dietary factors and polymorphisms in vitamin d metabolism genes: the risk and prognosis of colorectal cancer in northeast china
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/b0010cebf49a45be8aa3be8425639947
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