Genome-wide compendium and functional assessment of in vivo heart enhancers
Identification of non-coding variants has outstripped our ability to annotate and interpret them. Dickel et al. present a compendium of over 80,000 putative human heart enhancers and demonstrate that two conserved enhancers are required for proper cardiac function in mice.
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Nature Portfolio
2016
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oai:doaj.org-article:b001d43a207246388e738ba39f9b28762021-12-02T14:40:15ZGenome-wide compendium and functional assessment of in vivo heart enhancers10.1038/ncomms129232041-1723https://doaj.org/article/b001d43a207246388e738ba39f9b28762016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12923https://doaj.org/toc/2041-1723Identification of non-coding variants has outstripped our ability to annotate and interpret them. Dickel et al. present a compendium of over 80,000 putative human heart enhancers and demonstrate that two conserved enhancers are required for proper cardiac function in mice.Diane E. DickelIros BarozziYiwen ZhuYoko Fukuda-YuzawaMarco OsterwalderBrandon J. MannionDalit MayCailyn H. SpurrellIngrid Plajzer-FrickCatherine S. PickleElizabeth LeeTyler H. GarvinMomoe KatoJennifer A. AkiyamaVeena AfzalAh Young LeeDavid U. GorkinBing RenEdward M. RubinAxel ViselLen A. PennacchioNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Diane E. Dickel Iros Barozzi Yiwen Zhu Yoko Fukuda-Yuzawa Marco Osterwalder Brandon J. Mannion Dalit May Cailyn H. Spurrell Ingrid Plajzer-Frick Catherine S. Pickle Elizabeth Lee Tyler H. Garvin Momoe Kato Jennifer A. Akiyama Veena Afzal Ah Young Lee David U. Gorkin Bing Ren Edward M. Rubin Axel Visel Len A. Pennacchio Genome-wide compendium and functional assessment of in vivo heart enhancers |
| description |
Identification of non-coding variants has outstripped our ability to annotate and interpret them. Dickel et al. present a compendium of over 80,000 putative human heart enhancers and demonstrate that two conserved enhancers are required for proper cardiac function in mice. |
| format |
article |
| author |
Diane E. Dickel Iros Barozzi Yiwen Zhu Yoko Fukuda-Yuzawa Marco Osterwalder Brandon J. Mannion Dalit May Cailyn H. Spurrell Ingrid Plajzer-Frick Catherine S. Pickle Elizabeth Lee Tyler H. Garvin Momoe Kato Jennifer A. Akiyama Veena Afzal Ah Young Lee David U. Gorkin Bing Ren Edward M. Rubin Axel Visel Len A. Pennacchio |
| author_facet |
Diane E. Dickel Iros Barozzi Yiwen Zhu Yoko Fukuda-Yuzawa Marco Osterwalder Brandon J. Mannion Dalit May Cailyn H. Spurrell Ingrid Plajzer-Frick Catherine S. Pickle Elizabeth Lee Tyler H. Garvin Momoe Kato Jennifer A. Akiyama Veena Afzal Ah Young Lee David U. Gorkin Bing Ren Edward M. Rubin Axel Visel Len A. Pennacchio |
| author_sort |
Diane E. Dickel |
| title |
Genome-wide compendium and functional assessment of in vivo heart enhancers |
| title_short |
Genome-wide compendium and functional assessment of in vivo heart enhancers |
| title_full |
Genome-wide compendium and functional assessment of in vivo heart enhancers |
| title_fullStr |
Genome-wide compendium and functional assessment of in vivo heart enhancers |
| title_full_unstemmed |
Genome-wide compendium and functional assessment of in vivo heart enhancers |
| title_sort |
genome-wide compendium and functional assessment of in vivo heart enhancers |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/b001d43a207246388e738ba39f9b2876 |
| work_keys_str_mv |
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