Radiolysis generates a complex organosynthetic chemical network

Abstract The architectural features of cellular life and its ecologies at larger scales are built upon foundational networks of reactions between molecules that avoid a collapse to equilibrium. The search for life’s origins is, in some respects, a search for biotic network attributes in abiotic chem...

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Autores principales:	Zachary R. Adam, Albert C. Fahrenbach, Sofia M. Jacobson, Betul Kacar, Dmitry Yu. Zubarev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b002570706c2415198cfb4f7def22c45
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spelling	oai:doaj.org-article:b002570706c2415198cfb4f7def22c452021-12-02T10:49:34ZRadiolysis generates a complex organosynthetic chemical network10.1038/s41598-021-81293-62045-2322https://doaj.org/article/b002570706c2415198cfb4f7def22c452021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81293-6https://doaj.org/toc/2045-2322Abstract The architectural features of cellular life and its ecologies at larger scales are built upon foundational networks of reactions between molecules that avoid a collapse to equilibrium. The search for life’s origins is, in some respects, a search for biotic network attributes in abiotic chemical systems. Radiation chemistry has long been employed to model prebiotic reaction networks, and here we report network-level analyses carried out on a compiled database of radiolysis reactions, acquired by the scientific community over decades of research. The resulting network shows robust connections between abundant geochemical reservoirs and the production of carboxylic acids, amino acids, and ribonucleotide precursors—the chemistry of which is predominantly dependent on radicals. Moreover, the network exhibits the following measurable attributes associated with biological systems: (1) the species connectivity histogram exhibits a heterogeneous (heavy-tailed) distribution, (2) overlapping families of closed-loop cycles, and (3) a hierarchical arrangement of chemical species with a bottom-heavy energy-size spectrum. The latter attribute is implicated with stability and entropy production in complex systems, notably in ecology where it is known as a trophic pyramid. Radiolysis is implicated as a driver of abiotic chemical organization and could provide insights about the complex and perhaps radical-dependent mechanisms associated with life’s origins.Zachary R. AdamAlbert C. FahrenbachSofia M. JacobsonBetul KacarDmitry Yu. ZubarevNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zachary R. Adam Albert C. Fahrenbach Sofia M. Jacobson Betul Kacar Dmitry Yu. Zubarev Radiolysis generates a complex organosynthetic chemical network
description	Abstract The architectural features of cellular life and its ecologies at larger scales are built upon foundational networks of reactions between molecules that avoid a collapse to equilibrium. The search for life’s origins is, in some respects, a search for biotic network attributes in abiotic chemical systems. Radiation chemistry has long been employed to model prebiotic reaction networks, and here we report network-level analyses carried out on a compiled database of radiolysis reactions, acquired by the scientific community over decades of research. The resulting network shows robust connections between abundant geochemical reservoirs and the production of carboxylic acids, amino acids, and ribonucleotide precursors—the chemistry of which is predominantly dependent on radicals. Moreover, the network exhibits the following measurable attributes associated with biological systems: (1) the species connectivity histogram exhibits a heterogeneous (heavy-tailed) distribution, (2) overlapping families of closed-loop cycles, and (3) a hierarchical arrangement of chemical species with a bottom-heavy energy-size spectrum. The latter attribute is implicated with stability and entropy production in complex systems, notably in ecology where it is known as a trophic pyramid. Radiolysis is implicated as a driver of abiotic chemical organization and could provide insights about the complex and perhaps radical-dependent mechanisms associated with life’s origins.
format	article
author	Zachary R. Adam Albert C. Fahrenbach Sofia M. Jacobson Betul Kacar Dmitry Yu. Zubarev
author_facet	Zachary R. Adam Albert C. Fahrenbach Sofia M. Jacobson Betul Kacar Dmitry Yu. Zubarev
author_sort	Zachary R. Adam
title	Radiolysis generates a complex organosynthetic chemical network
title_short	Radiolysis generates a complex organosynthetic chemical network
title_full	Radiolysis generates a complex organosynthetic chemical network
title_fullStr	Radiolysis generates a complex organosynthetic chemical network
title_full_unstemmed	Radiolysis generates a complex organosynthetic chemical network
title_sort	radiolysis generates a complex organosynthetic chemical network
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b002570706c2415198cfb4f7def22c45
work_keys_str_mv	AT zacharyradam radiolysisgeneratesacomplexorganosyntheticchemicalnetwork AT albertcfahrenbach radiolysisgeneratesacomplexorganosyntheticchemicalnetwork AT sofiamjacobson radiolysisgeneratesacomplexorganosyntheticchemicalnetwork AT betulkacar radiolysisgeneratesacomplexorganosyntheticchemicalnetwork AT dmitryyuzubarev radiolysisgeneratesacomplexorganosyntheticchemicalnetwork
_version_	1718396611685515264

Radiolysis generates a complex organosynthetic chemical network

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